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Human diversity of killer cell immunoglobulin-like receptors and disease

Rajalingam R

Natural Killer (NK) cells are the third population of lymphocyte in the mononuclear cell compartment that triggers first-line of defense against viral infection and tumor transformation. Historically, NK cells were...
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Human Leukocyte Antigen-C Genotype and Killer Immunoglobulin-like Receptor-Ligand Matching in Korean Living Donor Liver Transplantation

Lee H, Park KH, Park HS, Ryu JH, Lim J, Kim Y, Na GH, Kim DG, Oh EJ

BACKGROUND: The interaction between killer immunoglobulin-like receptors (KIRs) and HLA class I regulates natural killer (NK) cell cytotoxicity and function. The impact of NK cell alloreactivity through KIR in liver...
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Killer Cell Immunoglobulin-like Receptor (KIR) Analysis in Adult Korean Patients with Acute Myeloid Leukemia

Kim HJ, Choi Y, Jeong HY, Min WS, Kim CC, Kim TG

BACKGROUND: The prevalent natural killer (NK) cells induce alloreaction against leukemic cells during post-transplant. NK cell alloreactivity depends on the compatibility of killer cell immunoglobulin-like receptors (KIR) epitopes for graft-versus-host...
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Frequency of Killer Cell Immunoglobulin-like Receptors (KIRs) in Korean Patients with Chronic HCV Infection

Sung PS, Choi HB, Kim SY, Hong SW, Park CH, Song MJ, Lee SW, Yoo CR, Choi SW, Han NI, Kim TG, Yoon SK

Natural killer (NK) cells play an important role in innate immunity, especially in the response to viral infections, such as hepatitis C virus (HCV). Killer cell immunoglobulin-like receptors (KIRs) are...
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Association of KIR (Killer Cell Immunoglobulin-like Receptor) Genotype with Psoriasis in Korean Population

Choi EJ, Choi HB, Kim SY, Yoon HY, Park MJ, Kim TY, Kim TG

BACKGROUND: Psoriasis is a multifactorial autoimmune skin disease with a pathogenesis that has remained obscure. Recently, T cells bearing natural killer receptors (NKRs) were precisely and strongly targeted as new...
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The Role of Aquaporin-4 in Cerebral Edema Formation after Focal Cerebral Ischemia in Rats

Song YJ, Bae HR, Ha SU, Huh JT

  • KMID: 2339860
  • J Korean Neurosurg Soc.
  • 2007 Jan;41(1):30-38.
OBJECTIVE: To elucidate the role of aquaporin-4(AQP4) in cerebral edema formation, we studied the expression and subcellular localization of AQP4 in astrocytes after focal cerebral ischemia. METHODS: Cerebral ischemia were induced...
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The Impact of HLA and KIR Ligand Mismatching on Unrelated Allogeneic Hematopoietic Stem Cell Transplantation in Korean Adult Patients

Park H, Rho EY, In JW, Kim I, Yoon SS, Park S, Shin S, Park KU, Song EY

BACKGROUND: The impact of HLA and KIR ligand mismatching on the outcome of hematopoietic stem cell transplantation (HSCT) remains unclear. Previous reports have identified considerable ethnic differences in the impact...
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Role of T lymphocyte in the pathogenesis of rheumatoid arthritis

Shim SC, Lim MK, Sheen DH

  • KMID: 2168059
  • Hanyang Med Rev.
  • 2005 May;25(2):26-35.
PURPOSE OF REVIEW: Rheumatoid arthritis (RA) is characterized by a chronic T-cell response that has escaped normal control mechanisms. This review summarizes recent insights in pathways that are functional in...
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HLA Mismatched Allogeneic Hematopoietic Stem Cell Transplantation

Kim HJ

Much of the success of hematopoietic stem cell transplantation (HSCT) has been due to the ability to overcome posttransplant complications, by performing HLA genotypically matched or even mismatched sibling donor...
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Targeted resequencing of candidate genes reveals novel variants associated with severe Behcet's uveitis

Kim SJ, Lee S, Park C, Seo JS, Kim JI, Yu HG

  • KMID: 2154268
  • Exp Mol Med.
  • 2013 Oct;45(10):e49.
Behcet's disease (BD) is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent uveitis, oral and genital ulcers and skin lesions. To identify some pathogenic variants associated with...
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Recipient's Killer Cell Immunoglobulin-like Receptor Genotype and Human Leukocyte Antigen C Ligand Influence the Clinical Outcome following Living Donor Liver Transplantation

Kim SJ, Kim DG, Kim TG, Choi HB, Jung ES

PURPOSE: The design of this study was to determine the most influential factor(s) on post-transplant immunological consequences, particularly with regard to the role of killer cell immunoglobulin-like receptors (KIRs) and...
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