- The Cannabinoid Agonist WIN55,212-2 Suppresses Opioid-induced Pruritus in Mice
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Lee H
- KMID: 2263295
- Anesth Pain Med.
- 2008 Jul;3(3):167-171.
BACKGROUND: Cannabinoid receptor agonists can reverse opioidinduced nausea and vomiting in animals, but have not yet been tested against opioid-induced pruritus. This study tests the hypothesis that a cannabinoid receptor... -
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- SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor
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Rhee MH, Kim SK
- KMID: 1095119
- J Vet Sci.
- 2002 Sep;3(3):179-184.
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive... -
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- The Role of Peripheral Cannabinoid Receptors Type 1 in Rats With Visceral Hypersensitivity Induced by Chronic Restraint Stress
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Shen L, Yang XJ, Qian W, Hou XH
- KMID: 2326162
- J Neurogastroenterol Motil.
- 2010 Jul;16(3):281-290.
BACKGROUND/AIMS: This study was designed to investigate the possibility that the enhanced nociceptive responsiveness associated with canabonoid type 1 receptors (CB1Rs) and identify its role in mediating visceral hypersensitivity induced... -
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- Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor
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Rhee MH
- KMID: 1095120
- J Vet Sci.
- 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase... -
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- The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
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Farzaei MH, Bahramsoltani R, Abdollahi , Rahimi R
- KMID: 2433449
- J Neurogastroenterol Motil.
- 2016 Oct;22(4):558-574.
- doi: 10.5056/jnm16001
Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process... -
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- Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction
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Jeon P, Yang S, Jeong H, Kim H
- KMID: 1447423
- Anat Cell Biol.
- 2011 Jun;44(2):135-142.
- doi: 10.5115/acb.2011.44.2.135
Cannabinoids have been proposed to possess neuroprotective properties; though their mechanism of action remains contentious, they are posited to prevent neurodegenerative disorders, including Parkinson's disease, the pathogenesis of which has... -
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- A Cannabinoid Receptor Agonist N-Arachidonoyl Dopamine Inhibits Adipocyte Differentiation in Human Mesenchymal Stem Cells
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Ahn S, Yi S, Seo WJ, Lee MJ, Song YK, Baek SY, Yu J, Hong SH, Lee J, Shin DW, Jeong LS, Noh M
- KMID: 2380330
- Biomol Ther.
- 2015 May;23(3):218-224.
- doi: 10.4062/biomolther.2014.137
Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and peroxisome proliferator-activated receptor gamma (PPARgamma). The stimuli to... -
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- No Association between (AAT)n Repeat Polymorphisms in the Cannabinoid Receptor 1 Gene and Smooth Pursuit Eye Movement Abnormality in Korean Patients with Schizophrenia
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Kim MJ, Kim CR, Park JW, Pak DH, Shin HD, Choi IG, Hahn SW, Hwang J, Lee YJ, Woo SI
- KMID: 2361590
- Korean J Biol Psychiatry.
- 2016 Nov;23(4):148-156.
- doi: 10.0000/kjbp.2016.23.4.148
OBJECTIVES: According to previous studies, the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. Some studies have linked the (AAT)n trinucleotide repeat polymorphism in CNR1... -
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- CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease
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Chung YC, Shin WH, Baek JY, Cho EJ, Baik HH, Kim SR, Won SY, Jin BK
- KMID: 2327678
- Exp Mol Med.
- 2016 Jan;48(1):e205.
- doi: 10.1038/emm.2015.100
The cannabinoid (CB2) receptor type 2 has been proposed to prevent the degeneration of dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. However, the mechanisms underlying CB2 receptor-mediated neuroprotection in MPTP mice... -
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- MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats
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Hou Q, Huang Y, Zhang C, Zhu S, Li P, Chen X, Hou Z, Liu F
- KMID: 2422855
- J Neurogastroenterol Motil.
- 2018 Oct;24(4):656-668.
- doi: 10.5056/jnm18037
BACKGROUND/AIMS: MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity... -
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- Frontier of Epilepsy Research - mTOR signaling pathway
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Cho CH
- KMID: 1009965
- Exp Mol Med.
- 2011 May;43(5):231-274.
- doi: 10.3858/emm.2011.43.5.032
Studies of epilepsy have mainly focused on the membrane proteins that control neuronal excitability. Recently, attention has been shifting to intracellular proteins and their interactions, signaling cascades and feedback regulation... -
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