- Conversion of a murine monoclonal antibody A13 targeting epidermal growth factor receptor to a human monoclonal antibody by guided selection
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Chang KH, Kim MS, Hong GW, Shin YN, Kim SH
- KMID: 1120142
- Exp Mol Med.
- 2012 Jan;44(1):52-59.
- doi: 10.3858/emm.2012.44.1.005
Epidermal growth factor receptor (EGFR) is an attractive target for tumor therapy because it is overexpressed in the majority of solid tumors and the increase in receptor expression levels has... -
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- Novel EGFR-TK Inhibitor EKB-569 Inhibits Hepatocellular Carcinoma Cell Proliferation by AKT and MAPK Pathways
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Kim H, Lim HY
- KMID: 1786011
- J Korean Med Sci.
- 2011 Dec;26(12):1563-1568.
- doi: 10.3346/jkms.2011.26.12.1563
Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular carcinoma (HCC). The aim of this study was to investigate the drug potential to... -
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- Transglutaminase 2 Expression Predicts Progression Free Survival in Non-Small Cell Lung Cancer Patients Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
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Jeong JH, Cho BC, Shim HS, Kim HR, Lim SM, Kim SK, Chung KY, Islam SM, Song JJ, Kim SY, Kim JH
- KMID: 1777495
- J Korean Med Sci.
- 2013 Jul;28(7):1005-1014.
- doi: 10.3346/jkms.2013.28.7.1005
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and in the constitutive activation of nuclear factor kappa B (NF-kappaB). We investigated the association of non-small cell lung... -
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- EGFR Polymorphism as a Predictor of Clinical Outcome in Advanced Lung Cancer Patients Treated with EGFR-TKI
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Jung M, Cho BC, Lee CH, Park HS, Kang YA, Kim SK, Chang J, Kim DJ, Rha SY, Kim JH, Lee JH
- KMID: 1414254
- Yonsei Med J.
- 2012 Nov;53(6):1128-1135.
- doi: 10.3349/ymj.2012.53.6.1128
PURPOSE: Mutations in the epidermal growth factor receptor (EGFR) have been confirmed as predictors of the efficacy of treatment with EGFR-tyrosine kinase inhibitors (TKIs). We investigated whether polymorphisms of the... -
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- Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation
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Hur GY, Lee SY, Lee SH, Kim SJ, Lee KJ, Jung JY, Lee EJ, Kang EH, Jung KH, Lee SY, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH
- KMID: 1047088
- Exp Mol Med.
- 2007 Jun;39(3):367-375.
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. EGFR has an intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through the... -
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