- Effect of adenosine on the release of (3H)-5-hydroxytryptamine during glucose/oxygen deprivation from rat hippocampal slices
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Lee KE, Cha KE, Pae YS
- KMID: 2285183
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):657-664.
The effects of adenosine, adenosine A1 receptor antagonist (DPCPX), or NMDA receptor antagonist (APV) on the spontaneous release of (3H)-5-hydroxytryptamine ((3H)-5-HT) during normoxic/normoglycemic or hypoxic/hypoglycemic period were studied in the rat hippocampal slices. The... -
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- The Effects of Intrathecal Adenosine A1 Receptor Agonists (R-PIA) on the Morphine Tolerance in a Rat Model of Postoperative Pain
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Jun IG, Piao LZ, Kwon MY, Park JY
- KMID: 2236625
- Korean J Anesthesiol.
- 2007 Feb;52(2):212-218.
- doi: 10.4097/kjae.2007.52.2.212
BACKGROUND: Analgesic tolerance to opioids has been described in both experimental and clinical conditions, which may limit their clinical utility. This study investigated the effects of intrathecal adenosine... -
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- Sleep Promoting Effect of Luteolin in Mice via Adenosine A1 and A2A Receptors
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Kim TH, Custodio R, Cheong JH, Kim HJ, Jung YS
- KMID: 2462886
- Biomol Ther.
- 2019 Nov;27(6):584-590.
- doi: 10.4062/biomolther.2019.149
Luteolin, a widespread flavonoid, has been known to have neuroprotective activity against various neurologic diseases such as epilepsy, and Alzheimer’s disease. However, little information is available regarding the hypnotic effect... -
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- A Polymorphism (rs10920568, A102A) of Adenosine A1 Receptor (ADORA1) Gene is Associated with Schizophrenia in Korean Population
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Hong MS, Kim BS, Kim YJ, Chung JH
- KMID: 2165275
- Exp Neurobiol.
- 2008 Jun;17(1):1-5.
- doi: 10.5607/en.2008.17.1.1
Adenosine A1 receptor (ADORA1) has a neuromodulatory activity in early stage of brain development. Recent studies have been suggested that a deficit in adenosinergic function may be a key factor... -
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- The Interaction of Gabapentin and N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on Mechanical Allodynia in Rats with a Spinal Nerve Ligation
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Park JY, Jun IG
- KMID: 1785829
- J Korean Med Sci.
- 2008 Aug;23(4):678-684.
- doi: 10.3346/jkms.2008.23.4.678
We examined the antiallodynic interaction between gabapentin and adenosine A1 receptor agonist, N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA), in a rat model of nerve ligation injury. Rats were prepared with ligation of left... -
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- The Mechanical Antiallodynic Effect of intrathecal Morphine and R-Phenylisopropyl-Adenosine in Rats with Spinal Nerve Ligation
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Park JY, Jun IG, Hwang JH
- KMID: 1860820
- Korean J Anesthesiol.
- 2003 Apr;44(4):568-576.
- doi: 10.4097/kjae.2003.44.4.568
BACKGORUND: A nerve ligation injury may produce a pain syndrome including mechanical allodynia. Usually the antiallodynic effect of morphine is diminished in a neuropathic rat model. However, in a previous... -
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- The Effects of Adenosine on Enhanced ICAM-1 Expression by IFN-gamma in Cultured Human Keratinocyte Cell Line HaCaT Cells
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Lim YS, Choi JH, Sung KJ, Myung KB
- KMID: 2303275
- Korean J Dermatol.
- 2000 Apr;38(4):472-480.
BACKGROUND: Intercellular adhesion molecule(ICAM)-1 mediates cell to cell adhesion by acting as a receptor for leukocyte surface antigen. Increased ICAM-1 expression was observed in chronic inflammatory skin diseases, such as... -
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- Protective Roles of Adenosine A1 Receptor Agonist and KATP Channel Opener in Adriamycin induced Cardiac Toxicity
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Lee S, Cho WG, Paik DJ, Lee BH, Baik TK, Kim WK, Chung HS
- KMID: 2115279
- Korean J Phys Anthropol.
- 2001 Mar;14(1):45-59.
Although adriamycin is a potent chemotherapeutic agent, it elicits serious adverse effects, including cardiac toxicity. Evidence suggests that congestive heart failure induced by adriamycin is mediated by oxidative stress. We... -
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- The Interaction of Morphine and Adenosine Receptor Agonists on Antiallodynia in Rats with a Nerve Ligation Injury
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Lee JR, Kim YK, Choi DK, Park JY, Kwak MJ, Hwang JH
- KMID: 2032001
- Korean J Anesthesiol.
- 2002 Jun;42(6):823-830.
- doi: 10.4097/kjae.2002.42.6.823
BACKGROUND: A Nerve ligation injury may produce a pain syndrome that includes tactile allodynia. Reversal effects on tactile allodynia have been demonstrated after an intrathecal administration of adenosine... -
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- Effects of adenosine receptor agonist on the rocuronium-induced neuromuscular block and sugammadex-induced recovery
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Kim YB, Lee S, Choi HR, In J, Chang YJ, Kim HJ, Ro YJ, Yang HS
- KMID: 2428080
- Korean J Anesthesiol.
- 2018 Dec;71(6):476-482.
- doi: 10.4097/kja.d.17.00011
BACKGROUND: Several types of receptors are found at neuromuscular presynaptic membranes. Presynaptic inhibitory A1 and facilitatory A2A receptors mediate different modulatory functions on acetylcholine release. This study investigated whether adenosine... -
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- Presynaptic Mechanism Underlying Regulation of Transmitter Release by G Protein Coupled Receptors
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Takahashi , Kajikawa Y, Kimura M, Saitoh N, Tsujimoto
- KMID: 1611227
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):69-76.
A variety of G protein coupled receptors (GPCRs) are expressed in the presynaptic terminals of central and peripheral synapses and play regulatory roles in transmitter release. The patch-clamp whole-cell recording... -
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- The Effect of ATP-sensitive Potassium Channel on R-PIA Induced Mechanical Antiallodynia in a Peripheral Neuropathic Rat
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Min HG, Seong SH, Jung SM, Shin JW, Gwak MJ, Leem JG, Lee C
- KMID: 2277971
- Korean J Pain.
- 2005 Dec;18(2):107-112.
- doi: 10.3344/kjp.2005.18.2.107
BACKGROUND: Nerve ligation injury may produce mechanical allodynia, but this can be reversed after an intrathecal administration of adenosine analogues. In many animal and human studies, ATP-sensitive potassium channel blockers... -
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- Effects of Ischemic Preconditioning, Adenosine and Pinacidil on Expression of Apoptosis in the Rectus Femoris Muscles of the Rats after Ischemia and Timely Reperfusion
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Kim BC, Paik DJ, Ahn DC, Cho WG, Lee KH, Hwang KS, Chung HS
- KMID: 2283107
- Korean J Phys Anthropol.
- 1998 Dec;11(2):349-360.
The ischemia and reperfusion injury of skeletal muscle is caused by generation of reactive oxygen species. Recently, apoptosis has been associated with oxidative stress in a number of cell systems.... -
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- The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat
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Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD
- KMID: 2432073
- Biomol Ther.
- 2019 Jan;27(1):101-106.
- doi: 10.4062/biomolther.2018.136
Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder... -
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- Effects of Ischemic Preconditioning,Adenosine and Pinacidil on the Changes in Immunoreactivities of Cu,Zn - and Mn - SOD in the Rectus Femoris Muscles of the Rats after Ischemia and Timely Reperfusion
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Paik DJ, Kim BC
- KMID: 2283106
- Korean J Phys Anthropol.
- 1998 Dec;11(2):327-347.
A brief episode of ischemia and reperfusion termed 'ischemic preconditioning' has been established as rendering muscle tolerance to damage during a subsequent prolonged ischemia. The effects of ischemic preconditioning in... -
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- Effects of Ischemic Preconditioning, Adenosine and Pinacidil on the Expression of Cu,Zn- and Mn-SOD mRNA in the Rectus Femoris Muscle of the Rat after Ischemia and Timely Reperfusion
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Paik DJ, Yoo YM, Hwang KS, Ahn DC, Chung HS, Kang BK
- KMID: 1578400
- Korean J Phys Anthropol.
- 2000 Mar;13(1):129-147.
A brief episode of ischemia and reperfusion termed 'ischemic preconditioning' has been established as rendering muscle tolerance to damage during a subsequent prolonged ischemia. The effects of ischemic preconditioning in... -
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- Effect of (R-)-N6-phenylisopropyladenosine (RPIA) Pretreatment on the alteration of Netural Cell dhesion Molecule
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Hwang SC, Hwang SJ, Cho WG, Jin CB, Chung HS
- KMID: 1539059
- J Korean Epilepsy Soc.
- 1999 Jun;3(1):22-32.
BACKGROUND: Various neuronal and glial factors which participate in neural differentiation, including neural cell adhesion molecule (NCAM), are upregulated in pathogenesis of temporal lobe epilesy (TLE).This study aimed to investigate... -
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