- The role of mitochondrial DNA mutation on neurodegenerative diseases
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Cha MY, Kim DK, Mook-Jung
- KMID: 2155415
- Exp Mol Med.
- 2015 Mar;47(3):e150.
- doi: 10.1038/emm.2014.122
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may... -
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- Oxygen-Dependent and -Independent Regulation of HIF-1alpha
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Chun YS, Kim MS, Park JW
- KMID: 1127245
- J Korean Med Sci.
- 2002 Oct;17(5):581-588.
- doi: 10.3346/jkms.2002.17.5.581
Hypoxia-inducible factor-1 (HIF-1) is composed of HIF-1alpha and HIF-1beta, and is a master regulator of oxygen homeostasis, playing critical roles in physiological and pathological processes. Normally, the formation and... -
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- NADPH oxidase mediated oxidative stress in hepatic fibrogenesis
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Paik YH, Brenner DA
- KMID: 1792602
- Korean J Hepatol.
- 2011 Dec;17(4):251-257.
- doi: 10.3350/kjhep.2011.17.4.251
NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in... -
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- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Redox signaling: hydrogen peroxide as intracellular messenger
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Rhee SG
- KMID: 1029931
- Exp Mol Med.
- 1999 Jun;31(2):53-59.
Although superoxide anions (O2.-) and H2O2 are generally considered to be toxic by-products of respiration, recent evidence suggests that the production of these reactive oxygen species (ROS) might be an integral component... -
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- Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK
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Ha YJ, Seul HJ, Lee JR
- KMID: 1097267
- Exp Mol Med.
- 2011 Feb;43(2):101-110.
- doi: 10.3858/emm.2011.43.2.012
Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K)... -
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- Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells
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Wan J, Bae MA, Song BJ
- KMID: 755668
- Exp Mol Med.
- 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify... -
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- Effect of Advanced Glycation End Products on Oxidative Stress and Senescence of Trabecular Meshwork Cells
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Park CH, Kim JW
- KMID: 1364866
- Korean J Ophthalmol.
- 2012 Apr;26(2):123-131.
- doi: 10.3341/kjo.2012.26.2.123
PURPOSE: To investigate the effect of advanced glycation end products (AGE) on oxidative stress and cellular senescence in cultured human trabecular meshwork cells (HTMC). METHODS: Primarily cultured HTMC were exposed to... -
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- Upregulation of Proinflammatory Cytokines in the Fetal Brain of the Gaucher Mouse
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Hong YB, Kim EY, Jung SC
- KMID: 2157830
- J Korean Med Sci.
- 2006 Aug;21(4):733-738.
- doi: 10.3346/jkms.2006.21.4.733
Gaucher disease is caused by a deficiency of glucocerebrosidase. Patients with Gaucher disease are divided into three major phenotypes: chronic nonneuronopathic, acute neuronopathic, and chronic neuronopathic, based on symptoms of... -
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- Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS
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Kim KA, Kim JY, Lee YA, Min A, Bahk YY, Shin MH
- KMID: 1501811
- Korean J Parasitol.
- 2013 Feb;51(1):61-68.
- doi: 10.3347/kjp.2013.51.1.61
Entamoeba histolytica, which causes amoebic colitis and occasionally liver abscess in humans, is able to induce host cell death. However, signaling mechanisms of colon cell death induced by E. histolytica... -
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- The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase
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Kim SM, Byun JS, Jung YD, Kang IC, Choi SY, Lee KY
- KMID: 755012
- Exp Mol Med.
- 1998 Dec;30(4):221-226.
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO... -
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- Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
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Kim SY, Kang HT, Choi HR, Park SC
- KMID: 991619
- Exp Mol Med.
- 2011 Jan;43(1):15-23.
- doi: 10.3858/emm.2011.43.1.002
Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle. However, the role of BLVRA in the... -
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- Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo
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Park KW, Lee HG, Jin BK, Lee YB
- KMID: 1091076
- Exp Mol Med.
- 2007 Dec;39(6):812-819.
A degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is expressed in LPS-injected rat cerebral... -
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- Gut Microbial Influence and Probiotics on Colorectal Cancer
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Myung DS, Joo YE
- KMID: 1775792
- Korean J Gastroenterol.
- 2012 Nov;60(5):275-284.
- doi: 10.4166/kjg.2012.60.5.275
The human intestinal microbiota is a community of 10(13)-10(14) microorganisms that harbor in the intestine and normally participate in a symbiotic relationship with human. Technical and conceptual advances have enabled... -
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- Diphenyleneiodonium Inhibits Apoptotic Cell Death of Gastric Epithelial Cells Infected with Helicobacter pylori in a Korean Isolate
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Cho SO, Lim JW, Kim H
- KMID: 2366360
- Yonsei Med J.
- 2015 Jul;56(4):1150-1154.
- doi: 10.3349/ymj.2015.56.4.1150
NADPH oxidase produces a large amount of reactive oxygen species (ROS) in Helicobacter pylori (H. pylori)-induced gastric epithelial cells. Even though ROS mediate apoptotic cell death, direct involvement of NADPH... -
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- Autophagy and bacterial infectious diseases
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Yuk JM, Yoshimori , Jo EK
- KMID: 1120128
- Exp Mol Med.
- 2012 Feb;44(2):99-108.
- doi: 10.3858/emm.2012.44.2.032
Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested... -
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- Selectively Decreased Expression of Peroxiredoxins Induced by Silica in Pulmonary Epithelial Cells
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Lee HL, Kim YS, Park JH, Chung WY, Lee KS, Oh YJ, Sheen SS, Park KJ, Hwang SC
- KMID: 1717945
- Korean J Intern Med.
- 2009 Sep;24(3):220-226.
- doi: 10.3904/kjim.2009.24.3.220
BACKGROUND/AIMS: Peroxiredoxin (Prx) belongs to a ubiquitous family of antioxidant enzymes that regulates many cellular processes through intracellular oxidative signal transduction pathways. Silica-induced lung damage involves reactive oxygen species (ROS)... -
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- Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage
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Ji AR, Ku SY, Cho MS, Kim YY, Kim YJ, Oh SK, Kim SH, Moon SY, Choi YM
- KMID: 946650
- Exp Mol Med.
- 2010 Mar;42(3):175-186.
- doi: 10.3858/emm.2010.42.3.018
Recently, reactive oxygen species (ROS) have been studied as a regulator of differentiation into specific cell types in embryonic stem cells (ESCs). However, ROS role in human ESCs (hESCs) is... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
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Liu T, Lee SY
- KMID: 2154235
- Exp Mol Med.
- 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many... -
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- Mitochondrial DNA Aberrations and Pathophysiological Implications in Hematopoietic Diseases, Chronic Inflammatory Diseases, and Cancers
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Kim HR, Won SJ, Fabian C, Kang MG, Szardenings M, Shin MG
- KMID: 2363141
- Ann Lab Med.
- 2015 Jan;35(1):1-14.
- doi: 10.3343/alm.2015.35.1.1
Mitochondria are important intracellular organelles that produce energy for cellular development, differentiation, and growth. Mitochondrial DNA (mtDNA) presents a 10- to 20-fold higher susceptibility to genetic mutations owing to the... -
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