- Downregulation of cellular prion protein inhibited the proliferation and invasion and induced apoptosis of Marek's disease virus-transformed avian T cells
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Wan X, Yang R, Liu G, Zhu M, Zhang T, Liu L, Wu R
- KMID: 2413166
- J Vet Sci.
- 2016 Jun;17(2):171-178.
- doi: 10.4142/jvs.2016.17.2.171
Cellular prion protein (PrP(C)) is ubiquitously expressed in the cytomembrane of a considerable number of eukaryotic cells. Although several studies have investigated the functions of PrP(C) in cell proliferation, cell... -
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- The C-terminal variable domain of LigB from Leptospira mediates binding to fibronectin
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Lin YP, Chang YF
- KMID: 1106228
- J Vet Sci.
- 2008 Jun;9(2):133-144.
- doi: 10.4142/jvs.2008.9.2.133
Adhesion through microbial surface components that recognize adhesive matrix molecules is an essential step in infection for most pathogenic bacteria. In this study, we report that LigB interacts with fibronectin... -
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- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
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Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
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- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
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Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
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- The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
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Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH
- KMID: 2359885
- Exp Mol Med.
- 2015 Dec;47(12):e198.
- doi: 10.1038/emm.2015.91
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is... -
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- Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
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Hwang WC, Kim MK, Song JH, Choi KY, Min DS
- KMID: 2155389
- Exp Mol Med.
- 2014 Dec;46(12):e124.
- doi: 10.1038/emm.2014.74
Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase... -
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- Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro
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Yuan S, Qiao T, Zhuang X, Chen W, Xing N, Zhang Q
- KMID: 2427147
- Yonsei Med J.
- 2016 Nov;57(6):1312-1323.
- doi: 10.3349/ymj.2016.57.6.1312
PURPOSE: The aim of our study was to explore the relationships between the M2 isoform of pyruvate kinase (PKM2) and the sensitivity of human non-small cell lung cancer (NSCLC) cells... -
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- Suppression of Aurora-A oncogenic potential by c-Myc downregulation
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Yang S, He S, Zhou X, Liu M, Zhu H, Wang Y, Zhang W, Yan S, Quan L, Bai J, Xu N
- KMID: 994399
- Exp Mol Med.
- 2010 Nov;42(11):759-767.
- doi: 10.3858/emm.2010.42.11.077
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how... -
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- Ultrasound-Guided Delivery of siRNA and a Chemotherapeutic Drug by Using Microbubble Complexes: In Vitro and In Vivo Evaluations in a Prostate Cancer Model
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Bae YJ, Yoon YI, Yoon TJ, Lee HJ
- KMID: 2455420
- Korean J Radiol.
- 2016 Aug;17(4):497-508.
- doi: 10.3348/kjr.2016.17.4.497
OBJECTIVE: To evaluate the effectiveness of ultrasound and microbubble-liposome complex (MLC)-mediated delivery of siRNA and doxorubicin into prostate cancer cells and its therapeutic capabilities both in vitro and in vivo. MATERIALS... -
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- Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts
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Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH
- KMID: 1022119
- Exp Mol Med.
- 2011 Aug;43(8):446-454.
- doi: 10.3858/emm.2011.43.8.050
Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue... -
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- Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase
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Jung GA, Shin BS, Jang YS, Sohn JB, Woo SR, Kim JE, Choi G, Lee KM, Min BH, Lee KH, Park GH
- KMID: 1123367
- Exp Mol Med.
- 2011 Oct;43(10):550-560.
- doi: 10.3858/emm.2011.43.10.061
Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine... -
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- Up-regulation of BLT2 is critical for the survival of bladder cancer cells
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Seo JM, Cho KJ, Kim EY, Choi MH, Chung BC, Kim JH
- KMID: 1109401
- Exp Mol Med.
- 2011 Mar;43(3):129-137.
- doi: 10.3858/emm.2011.43.3.014
The incidence rates of urinary bladder cancer continue to rise yearly, and thus new therapeutic approaches and early diagnostic markers for bladder cancer are urgently needed. Thus, identifying the key... -
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- Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled
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Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH
- KMID: 1009391
- Exp Mol Med.
- 2009 Oct;41(10):695-706.
- doi: 10.3858/emm.2009.41.10.076
Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and... -
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- Knockdown of Moesin Expression Accelerates Cellular Senescence of Human Dermal Microvascular Endothelial Cells
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Lee JH, Yoo JH, Oh SH, Lee KY, Lee KH
- KMID: 1074998
- Yonsei Med J.
- 2010 May;51(3):438-447.
- doi: 10.3349/ymj.2010.51.3.438
PURPOSE: Endothelial cells maintain the homeostasis of blood, which consists of plasma and cellular components, and regulate the interaction between blood and the surrounding tissues. They also have essential roles... -
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- STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells
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Choi HJ, Lee JH, Park SY, Cho JH, Han JS
- KMID: 1109432
- Exp Mol Med.
- 2009 Feb;41(2):94-101.
- doi: 10.3858/emm.2009.41.2.012
Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of... -
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- The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein
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Park E, Choi Y, Ahn E, Park I, Yun Y
- KMID: 1009394
- Exp Mol Med.
- 2009 Oct;41(10):728-736.
- doi: 10.3858/emm.2009.41.10.079
The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified... -
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- Inhibitory effect of receptor for advanced glycation end products (RAGE) on the TGF-beta-induced alveolar epithelial to mesenchymal transition
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Song JS, Kang CM, Park CK, Yoon HK, Lee SY, Ahn JH, Moon HS
- KMID: 1022128
- Exp Mol Med.
- 2011 Sep;43(9):517-524.
- doi: 10.3858/emm.2011.43.9.059
Idiopathic pulmonary fibrosis (IPF) is a lethal parenchymal lung disease characterized by myofibroblast proliferation. Alveolar epithelial cells (AECs) are thought to produce myofibroblasts through the epithelial to mesenchymal transition (EMT).... -
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- Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
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Yun BR, Lee MJ, Kim JH, Kim IH, Yu GR, Kim DG
- KMID: 994402
- Exp Mol Med.
- 2010 Nov;42(11):787-797.
- doi: 10.3858/emm.2010.42.11.082
Cholangiocarcinoma (CC) is a chemoresistant intrahepatic bile duct carcinoma with a poor prognosis. The aims of this study were to identify molecular pathways that enhance sesquiterpene lactone parthenolide (PTL)-induced anticancer... -
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- SIRT1 promotes DNA repair activity and deacetylation of Ku70
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Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH
- KMID: 1103676
- Exp Mol Med.
- 2007 Feb;39(1):8-13.
Human SIRT1 controls various physiological responses including cell fate, stress, and aging, through deacetylation of its specific substrate protein. In processing DNA damage signaling, SIRT1 attenuates a cellular apoptotic response... -
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- Glucosamine induces cell death via proteasome inhibition in human ALVA41 prostate cancer cell
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Liu BQ, Meng X, Li C, Gao YY, Li N, Niu XF, Guan Y, Wang HQ
- KMID: 1022124
- Exp Mol Med.
- 2011 Sep;43(9):487-493.
- doi: 10.3858/emm.2011.43.9.055
Glucosamine, a naturally occurring amino monosaccharide, has been reported to play a role in the regulation of apoptosis more than half century. However the effect of glucosamine on tumor cells... -
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