- Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists
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Kim EA, Jung KC, Sohn UD, Im C
- KMID: 2285372
- Korean J Physiol Pharmacol.
- 2009 Feb;13(1):55-59.
- doi: 10.4196/kjpp.2009.13.1.55
Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha4beta2 and h alpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity... -
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- Cytotoxic Activity and Three-Dimensional Quantitative Structure Activity Relationship of 2-Aryl-1,8-naphthyridin-4-ones
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Kim YJ, Kim EA, Chung ML, Im C
- KMID: 2285389
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):511-516.
- doi: 10.4196/kjpp.2009.13.6.511
A series of substituted 2-arylnaphthyridin-4-one analogues, which were previously synthesized in our laboratory, were evaluated for their in vitro cytotoxic activity against human lung cancer A549 and human renal cancer... -
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- Cytotoxic Activity and Quantitative Structure Activity Relationships of Arylpropyl Sulfonamides
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Hwang YJ, Park SM, Yim CB, Im C
- KMID: 1429304
- Korean J Physiol Pharmacol.
- 2013 Jun;17(3):237-243.
- doi: 10.4196/kjpp.2013.17.3.237
B13 is a ceramide analogue and apoptosis inducer with potent cytotoxic activity. A series of arylpropyl sulfonamide analogues of B13 were evaluated for their cytotoxicity using MTT assays in prostate... -
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- Evaluation of Advanced Structure-Based Virtual Screening Methods for Computer-Aided Drug Discovery
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Lee HS, Choi JW, Yoon SJ
- KMID: 2166251
- Genomics Inform.
- 2007 Mar;5(1):24-29.
Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to... -
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- Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer
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Hwang YJ, Chung ML, Sohn UD, Im C
- KMID: 2285479
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):517-523.
- doi: 10.4196/kjpp.2013.17.6.517
Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These... -
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- Assessment of quantitative structure-activity relationship of toxicity prediction models for Korean chemical substance control legislation
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Kim KY, Shin SE, No KT
- KMID: 2380074
- Environ Health Toxicol.
- 2015 ;30(Suppl):s2015007.
- doi: 10.5620/eht.s2015007
OBJECTIVES: For successful adoption of legislation controlling registration and assessment of chemical substances, it is important to obtain sufficient toxicological experimental evidence and other related information. It is also essential... -
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- Cytotoxicities and Quantitative Structure Activity Relationships of B13 Sulfonamides in HT-29 and A549 Cells
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Lee SK, Park SM, Im C
- KMID: 2285430
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):423-429.
- doi: 10.4196/kjpp.2011.15.6.423
B13 analogues are being considered as therapeutic agents for cancer cells, since B13 is a ceramide analogue and inhibits ceramidase to promote apoptosis in cancer cells. B13 sulfonamides are assumed... -
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- Natural radioprotectors and their impact on cancer drug discovery
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Kuruba V, Gollapalli P
- KMID: 2434315
- Radiat Oncol J.
- 2018 Dec;36(4):265-275.
- doi: 10.3857/roj.2018.00381
Cancer is a complex multifaceted illness that affects different patients in discrete ways. For a number of cancers the use of chemotherapy has become standard practice. Chemotherapy is a use... -
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- Nanoparticles-A Thoracic Toxicology Perspective
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Duffin R, Mills NL, Donaldson
- KMID: 2158160
- Yonsei Med J.
- 2007 Aug;48(4):561-572.
- doi: 10.3349/ymj.2007.48.4.561
A substantial literature demonstrates that the main ultrafine particles found in ambient urban air are combustion-derived nanoparticles (CDNP) which originate from a number of sources and pose a hazard to... -
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