- Rapid Identification of Methylglyoxal Trapping Constituents from Onion Peels by Pre-column Incubation Method
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Kim JH, Kim MI, Syed AS, Jung K, Kim CY
- KMID: 2401575
- Nat Prod Sci.
- 2017 Dec;23(4):247-252.
- doi: 10.20307/nps.2017.23.4.247
The methylglyoxal (MGO) trapping constituents from onion (Allium cepa L.) peels were investigated using pre-column incubation of MGO and crude extract followed by HPLC analysis. The peak areas of MGO... -
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- Effects of oxidative stress on the expression of aldose reductase in vascular smooth muscle cells
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Kim HJ, Chang KC, Seo HG
- KMID: 1606950
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):271-278.
Oxidative stress and methylglyoxal (MG), a reactive dicarbonyl metabolites produced by enzymatic and non-enzymatic reaction of normal metabolism, induced aldose reductase (AR) expression in rat aortic smooth muscle cells (SMC). AR expression was... -
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- Effect of Methylglyoxal on the Oxidative Stress in Trabecular Meshwork Cells
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Lee SH, Kim SH, Kim JW
- KMID: 2212777
- J Korean Ophthalmol Soc.
- 2009 Oct;50(10):1569-1575.
- doi: 10.3341/jkos.2009.50.10.1569
PURPOSE: To investigate the effect of methylglyoxal (MG), intermediate metabolite of advanced glycation end products(AGE), on the induction of oxidative stress in human trabecular meshwork cells (HTMC). METHODS: Primarily cultured HTMC... -
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- Methylglyoxal Induces Apoptosis Mediated by Reactive Oxygen Species in Bovine Retinal Pericytes
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Kim J, Son JW, Lee JA, Oh YS, Shinn SH
- KMID: 1785701
- J Korean Med Sci.
- 2004 Feb;19(1):95-100.
- doi: 10.3346/jkms.2004.19.1.95
One of the histopathologic hallmarks of early diabetic retinopathy is the loss of pericytes. Evidences suggest that the pericyte loss in vivo is mediated by apoptosis. However, the underlying cause... -
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- Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction
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Do MH, Kim SY
- KMID: 2375035
- Biomol Ther.
- 2017 Mar;25(2):158-164.
- doi: 10.4062/biomolther.2016.034
Methylglyoxal (MGO) is a highly reactive metabolite of glucose which is known to cause damage and induce apoptosis in endothelial cells. Endothelial cell damage is implicated in the progression of... -
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- Study on the Methylglyoxal-induced Apoptosis in Bovine Retinal Pericytes
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Kim J, Lee SH, Son JW, Lee JA, Oh YS, Shinn SH
- KMID: 1575481
- J Korean Diabetes Assoc.
- 2004 Jun;28(3):199-207.
BACKGROUND: One of the histopathological hallmarks of early diabetic retinopathy is the loss of pericytes. Evidences suggest that this pericyte loss in vivo is mediated by apoptosis. However, the underlying... -
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- Glucose Toxicity and Pancreatic Beta Cell Dysfunction in Type 2 Diabetes
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Won KC, Yoon JS
- KMID: 2298087
- Korean Diabetes J.
- 2008 Jun;32(3):175-181.
- doi: 10.4093/kdj.2008.32.3.175
The adverse effects of prolonged exposure of pancreatic islets to supraphysiologic glucose concentrations (i.e. glucose toxicity) is mediated at least in part by glucose oxidation and the subsequent generation of... -
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- Effect of Manuka Honey on Transforming Growth Factor Beta-1-Induced Extracelluar Matrix Production in Nasal Polyp Derived Fibroblasts
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Kil BK, Kim BM, Kang BJ, Ye MK, Shin SH
- KMID: 2451614
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Jun;62(6):336-342.
- doi: 10.3342/kjorl-hns.2018.00682
BACKGROUND AND OBJECTIVES: Manuka honey has anti-microbial, anti-inflammatory, and anti-proliferative action with a high concentration of methylglyoxal compound. It is also effective in killing Staphylococcus aureus biofilm and effective for... -
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- No short-term effects of calorie-controlled Mediterranean or fast food dietary interventions on established biomarkers of vascular or metabolic risk in healthy individuals
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Parcina M, Brune M, Kaese V, Zorn M, Spiegel R, Vojvoda V, Fleming T, Rudofsky G, Paul Nawroth P
- KMID: 2313825
- Nutr Res Pract.
- 2015 Apr;9(2):165-173.
- doi: 10.4162/nrp.2015.9.2.165
BACKGROUND/OBJECTIVES: This study addressed the question whether the composition of supposedly 'healthy' or 'unhealthy' dietary regimes has a calorie-independent short-term effect on biomarkers of metabolic stress and vascular risk in... -
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- Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells both in vitro and in vivo
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Kim J, Kim OS, Kim CS, Sohn E, Jo K, Kim JS
- KMID: 1120135
- Exp Mol Med.
- 2012 Feb;44(2):167-175.
- doi: 10.3858/emm.2012.44.2.012
The formation of advanced glycation end products (AGEs) has been considered to be a potential causative factor of injury to lens epithelial cells (LECs). Damage of LECs is believed to... -
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