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Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer

Song T, Jeon HK, Hong JE, Choi JJ, Kim TJ, Choi CH, Bae DS, Kim BG, Lee JW

PURPOSE: This study was conducted to investigate whether a proton pump inhibitor (PPI) could enhance chemosensitivity via the inhibition of vacuolar-type H⁺ ATPase (V-ATPase) in cervical cancer. MATERIALS AND METHODS: The...
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Expression of Aquaporin-6 in Intercalated Cell subtypes in Rat and Mouse Kidney

Hwang JS, Kim YH, Park EY, Kim WY, Kim J

  • KMID: 2092914
  • Korean J Anat.
  • 2008 Mar;41(1):21-28.
Aquaporin-6 (AQP6) is a water channel protein located in intracellular vesicles of the proximal tubules and in intercalated cells (ICs) in the collecting duct (CD) of the rat kidney. The...
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Identification of Differentially Expressed Genes in Murine Hippocampus by Modulation of Nitric Oxide in Kainic Acid-induced Neurotoxic Animal Model

Suh YA, Kwon OM, Yim SY, Lee HJ, Kim SS

  • KMID: 1512895
  • Korean J Physiol Pharmacol.
  • 2007 Aug;11(4):149-154.
Kainic acid (KA) causes neurodegeneration, but no consensus has been reached concerning its mechanism. Nitric oxide may be a regulator of the mechanism. We identified differentially expressed genes in the...
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Altered Regulation of Renal Acid Base Transporters in Response to Ammonium Chloride Loading in Rats

Kim EY, Choi JS, Lee KE, Kim CS, Bae EH, Ma SK, Kim SH, Lee JU, Kim SW

The role of the kidney in combating metabolic acidosis has been a subject of considerable interest for many years. The present study was aimed to determine whether there is an...
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Expression of H(+)-ATPase in Inner Medullary Collecting Duct Cells of Aquaporin-3-Deficient Mice

Lee EJ, Kim WY, Han KH, Kim H, Kim J

  • KMID: 2092814
  • Korean J Anat.
  • 2003 Oct;36(5):443-455.
It has been reported that the decrease in urinary pH observed in AQP1 null mice with a urinary concentrating defect is due to upregulation of H(+)-ATPase in the IMCD. This...
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Expression of an Anion Exchanger Pendrin in Human Kidney

Kim WY, Kim GH, Han KH, Song HK, Han JS, Kim J

  • KMID: 2224506
  • Korean J Anat.
  • 2004 Jun;37(3):263-273.
It has been reported that new apical anion exchanger perndrin, encoded by the pendred syndrome (PDS/pds, Slc26A4) gene, was expressed in the AE1-negative intercalated cells of rat and mouse kidneys....
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Action of Mitochondrial Substrates on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Lee HI, Chun SW

Recent studies indicate that mitochondria are an important source of reactive oxygen species (ROS) in the spinal dorsal horn. In our previous study, application of malate, a mitochondrial electron transport...
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Regulation of Vacuolar H+-ATPase c Gene Expression by Oxidative Stress

Kwak WJ, Kim SM, Kim MS, Kang JH, Kim DJ, Kim HS, Kown OJ, Kim IK, Jeong SW

  • KMID: 1600110
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):275-282.
By using differential display, we identified one of the genes encoding the multi-subunit complex protein V-ATPase, c subunit gene (ATP6L), and showed alterations of the gene expression by oxidative stresses....
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Changes of Urinary Acidification and Collecting Duct H(+)-ATPase Abundance in Response to Chronic Diuretic Administration

Kim GH, Na KY, Han JS, Oh YK, Lee JS, Joo KW, Earm JH

  • KMID: 1611204
  • Korean J Nephrol.
  • 2002 Mar;21(2):222-231.
PURPOSE: Commonly used diuretics such as furosemide and hydrochlorothiazide may cause metabolic alkalosis by increasing proton secretion from distal nephron. We evaluated changes in urinary acidification and abundance of proton-secreting...
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Biopsy-Proven Type 1 Renal Tubular Acidosis in a Patient with Metabolic Acidosis

Kang SH, Kim J, Park JW

No abstract available.
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Effect of acute respiratory acidosis and alkalosis on the subtypes of intercalated cells in rat kidney

Lim CM, Kim YH, Han KH, Cha JH, Jung JY, Lim SW, Chung JW, Kim J

  • KMID: 2224537
  • Korean J Anat.
  • 2000 Dec;33(6):751-762.
Intercalated cells play a major role in proton and bicarbonate secretion in the collecting duct of kidney. A third type of intercalated cell (non A-non B cell), besides type A...
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Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts

Kim BW, Choo HJ, Lee JW, Kim JH, Ko YG

  • KMID: 1123769
  • Exp Mol Med.
  • 2004 Oct;36(5):476-485.
Mitochondrial biogenesis is known to accompany adipogenesis to complement ATP and acetyl-CoA required for lipogenesis. Here, we demonstrated that mitochondrial proteins such as ATP synthase alpha and beta, and cytochrome...
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Refractory Hypertension and Isosexual Pseudoprecocious Puberty Associated with Renin-Secreting Ovarian Steroid Cell Tumor in a Girl

Lee SH, Kang MS, Lee GS, Chung WY

Steroid cell tumor, not otherwise specified (NOS), are rare ovarian tumor, in addition, it is more rare in children. The majority of these tumors produce several steroid hormones, particularly testosterone....
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A Randomized, Prospective, Comparative, Multicenter Study of Rabeprazole and Ranitidine in the Treatment of Reflux Esophagitis

Jeong HY, Lee BS, Sung JK, Lee TY, Yoon SJ, Kim SJ, Chung IK, Lee SH, Shin JE, Lee DS, Baek JT, Nam SW, Yoon SJ, Kim SH, Lee GS, Lee JM, Kim AN, Oh JI

  • KMID: 1079899
  • Korean J Gastroenterol.
  • 2006 Jan;47(1):15-21.
BACKGROUND/AIMS: This study was done to evaluate the efficacy of rabeprazole (proton-pump-inhibitor) and ranitidine (H2-receptor antagonist) in the symptom relief and treatment of erosive esophagitis diagnosed by endoscopy. METHODS:...
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Significance of Non-erosive Minimal Esophageal Lesions in Gastro-esophageal Reflux Disorder

Hong SP, Park PW, Hwang SG, Ko KH, Kwak SY, Kim SH, Kwon KS, Shin YW, Ryu JK, Ryu KH, Park SJ, Won WH, Yoo HM, Bae HM, Park MJ, Woo YK, Kim KC, Kim KH, Na SH, Kim JW

  • KMID: 759694
  • Korean J Intern Med.
  • 2004 Jun;19(2):93-98.
BACKGROUND: Non-erosive reflux disorder, which represents more than 60% of gastro-esophageal reflux disorders, lacks objective parameters for diagnosis. The purpose of this study was to evaluate the correlation between non-erosive...
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