- Fas-mediated apoptosis and expression of related genes in human malignant hematopoietic cells
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Kim KM, Lee KH, Hong YS, Park HY
- KMID: 755108
- Exp Mol Med.
- 2000 Dec;32(4):246-254.
Fas transduces apoptotic signals upon cross-linking with the Fas ligand (FasL), which is experimentally replaced by agonistic anti-Fas monoclonal antibodies (mAb). Of eight human malignant hematopoietic cell lines... -
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- Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
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Hong YS, Ham YA, Choi JH, Kim JG
- KMID: 755076
- Exp Mol Med.
- 2000 Sep;32(3):127-134.
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic... -
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- TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells
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Lee JH, Park BJ, Park JH, Yang MH, Chi SG
- KMID: 755040
- Exp Mol Med.
- 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in... -
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- Nuclear overexpression of bcl-2 oncoprotein during the progression of human stomach cancer
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Lee SS, Cho KJ, Hong SI, Myoung NK, Jang JJ
- KMID: 1064962
- J Korean Med Sci.
- 1998 Apr;13(2):153-158.
- doi: 10.3346/jkms.1998.13.2.153
We unexpectedly observed strong nuclear overexpression of bcl-2 protein in advanced stomach cancer. As far as we know, such expression has not yet been reported. To investigate the significance... -
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- Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2
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Kim BE, Lee JH, Kim HS, Kwon OJ, Jeong SW, Kim IK
- KMID: 1123765
- Exp Mol Med.
- 2004 Oct;36(5):444-453.
delta12-Prostaglandin (PG) J2 is known to elicit an anti-neoplastic effects via apoptosis induction. Previous study showed delta12-PGJ2-induced apoptosis utilized caspase cascade through cytochrome c-dependent pathways in HeLa cells. In this... -
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- IL-1beta Acts in Synergy with Endogenous IL-1beta in A375-S2 Human Melanoma Cell Apoptosis Through Mitochondrial Pathway
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Wang C, Wang MW, Tashiro SI, Onodera S, Ikejima T
- KMID: 1712732
- J Korean Med Sci.
- 2005 Aug;20(4):555-561.
- doi: 10.3346/jkms.2005.20.4.555
Interleukin-1beta (IL-1beta) is a pivotal proinflammatory cytokine. To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay... -
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- Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at the early stage of colorectal carcinogenesis
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Cho JH, Roe IH, Lim CY, Park DK, Kim WH, Kim YI
- KMID: 2157547
- J Korean Med Sci.
- 2000 Dec;15(6):667-674.
- doi: 10.3346/jkms.2000.15.6.667
We analyzed the expression of p21, bcl2, and p53 in normal and different pathologic mucosa of the human colorectum using immunohistochemistry and cold polymerase chain reaction-single strand conformation polymorphism. The topography... -
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- A priming role of local estrogen on exogenous estrogen-mediated synaptic plasticity and neuroprotection
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Chamniansawat S, Chongthammakun S
- KMID: 1383803
- Exp Mol Med.
- 2012 Jun;44(6):403-411.
The localization of estrogen (E2) has been clearly shown in hippocampus, called local hippocampal E2. It enhanced neuronal synaptic plasticity and protected neuron form cerebral ischemia, similar to those effects... -
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