- Molecular imaging of membrane proteins and microfilaments using atomic force microscopy
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Jung SH, Park D, Park JH, Kim YM, Ha KS
- KMID: 983952
- Exp Mol Med.
- 2010 Sep;42(9):597-605.
- doi: 10.3858/emm.2010.42.9.064
Atomic force microscopy (AFM) is an emerging technique for a variety of uses involving the analysis of cells. AFM is widely applied to obtain information about both cellular structural and... -
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- Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by delta12-prostaglandin J2
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Kim BE, Lee JH, Kim HS, Kwon OJ, Jeong SW, Kim IK
- KMID: 1123765
- Exp Mol Med.
- 2004 Oct;36(5):444-453.
delta12-Prostaglandin (PG) J2 is known to elicit an anti-neoplastic effects via apoptosis induction. Previous study showed delta12-PGJ2-induced apoptosis utilized caspase cascade through cytochrome c-dependent pathways in HeLa cells. In this... -
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- Receptors for Treponema pallidum Attachment to the Surface and Matrix Proteins of Cultured Human Dermal Microvascular Endothelial Cells
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Lee JH, Choi HJ, Jung J, Lee MG, Lee JB, Lee KH
- KMID: 720865
- Yonsei Med J.
- 2003 Jun;44(3):371-378.
- doi: 10.3349/ymj.2003.44.3.371
Pathogenicity of Treponema pallidum may depend upon the binding of Treponema pallidum to matrix proteins, especially to fibronectin. Infectious organism or cell to matrix interactions are mediated by a family... -
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- The functional role of the CARM1-SNF5 complex and its associated HMT activity in transcriptional activation by thyroid hormone receptor
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Choi HK, Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Ahn YH, Kim KS, Kim K, Yoon HG
- KMID: 756078
- Exp Mol Med.
- 2007 Aug;39(4):544-555.
We have investigated the function and mechanisms of the CARM1-SNF5 complex in T3-dependent transcriptional activation. Using specific small interfering RNAs (siRNA) to knock down coactivators in HeLa alpha2 cells, we... -
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- 14-3-3epsilon protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cells
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Lee EK, Lee YS, Lee H, Choi CY, Park SH
- KMID: 1058019
- Exp Mol Med.
- 2009 Jul;41(7):453-461.
- doi: 10.3858/emm.2009.41.7.050
One of the 14-3-3 protein isoforms, 14-3-3epsilon, was previously shown to be increased during skin aging. We suggest here a possible role for the 14-3-3epsilon protein in skin aging by... -
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- The effect of oxygen on retinal degeneration in wild-type and hsp70.1 knockout neonatal retinal degeneration mice
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Choi MY, Yu YS, Kim SK, Kim YJ, Seo JS
- KMID: 754285
- Korean J Ophthalmol.
- 2001 Jun;15(1):1-7.
- doi: 10.3341/kjo.2001.15.1.1
The present study examined the effect of oxygen on photoreceptor degeneration in the retina of heat shock protein 70.1 (hsp70.1) knockout type and wild-type retinal degeneration (rd) mice. All the... -
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- Mest Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting the Wnt/beta-Catenin Signaling Pathway
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Li W, Zhu C, Li Y, Wu Q, Gao R
- KMID: 1774562
- Gut Liver.
- 2014 May;8(3):282-291.
BACKGROUND/AIMS: The Wnt/beta-catenin signaling pathway has been reported to play an important role in liver fibrosis. This study was designed to investigate whether mesoderm-specific transcript homologue (Mest), a strong negative... -
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- Role of TGFBIp in Wound Healing and Mucin Expression in Corneal Epithelial Cells
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Maeng YS, Lee GH, Lee B, Choi SI, Kim TI, Kim EK
- KMID: 2427133
- Yonsei Med J.
- 2017 Mar;58(2):423-431.
- doi: 10.3349/ymj.2017.58.2.423
PURPOSE: Transforming growth factor-β-induced protein (TGFBIp) is highly expressed in the cornea, and mutant TGFBIp induces corneal diseases. However, the function of TGFBIp in cornea epithelium is not fully investigated.... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- The Role of Hepatitis C Virus Core Protein on Liver Fibrogenesis: A Study Using an In Vitro Co-culture System
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Shin JY, Yoon SK, Wang JS, Hur W, Ryu JS, Bae SH, Choi JY, Yang JM, Yang SH, Sung YC, Chung KW, Sun HS
- KMID: 1112191
- Korean J Gastroenterol.
- 2003 Nov;42(5):400-408.
BACKGROUND/AIMS: The study of liver fibrogenesis by hepatitis C virus (HCV) has been limited due to the lack of an efficiency in vitro culture systems. In the present study,... -
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- The Effect of Interleukin-4 and Amphiregulin on the Proliferation of Human Airway Smooth Muscle Cells and Cytokine Release
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Shim JY, Park SW, Kim DS, Shim JW, Jung HL, Park MS
- KMID: 1783073
- J Korean Med Sci.
- 2008 Oct;23(5):857-863.
- doi: 10.3346/jkms.2008.23.5.857
Airway smooth muscle (ASM) hyperplasia and angiogenesis are important features associated with airway remodeling. We investigated the effect of IL-4 and amphiregulin, an epidermal growth factor family member, on the... -
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- Escherichia coli O157:H7 adherence to HEp-2 cells is implicated with curli expression and outer membrane integrity
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Kim SH, Kim YH
- KMID: 1120067
- J Vet Sci.
- 2004 Jun;5(2):119-124.
Escherichia coli (E. coli) has ability to express thin aggregative fimbriae, known as curli, on the cell surface. Previously, a few example of curli expression in serogroup O157:H7 of enterohemorrhagic... -
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- Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells
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Moon SH, Kim HW, Kim JS, Park JH, Kim H, Eu GJ, Cho HS, Kang GM, Lee KH, Cho MH
- KMID: 1093633
- J Vet Sci.
- 2004 Dec;5(4):369-378.
Evidences show that eukaryotic mRNAs can perform protein translation through internal ribosome entry sites (IRES). 5'-Untranslated region of the mRNA encoding apoptotic protease-activating factor 1 (Apaf-1) contains IRES, and, thus,... -
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- Overexpression of CIITA in T Cells Aggravates Th2-Mediated Colitis in Mice
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Kim TW, Park HJ, Choi EY, Jung KC
- KMID: 1781909
- J Korean Med Sci.
- 2006 Oct;21(5):877-882.
- doi: 10.3346/jkms.2006.21.5.877
The MHC class II transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC class II restricted antigen presentation. Previously we suggested another role of CIITA in Th1/Th2... -
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- The Comparison of Cytotoxic T-Lymphocyte Effects of Dendritic Cells Stimulated by the Folate Binding Protein Peptide Cultured with IL-15 and IL-2 in Solid Tumor
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Kim DK, Kim JH, Kim YT, Kim JW, Ioannides
- KMID: 1093943
- Yonsei Med J.
- 2002 Dec;43(6):691-700.
- doi: 10.3349/ymj.2002.43.6.691
The current modalities for treating cancer employ not only single but multiple approaches involving surgery, radiotherapy and chemotherapy. Unfortunately, the survival outcome is not promising even with these approaches. Alternative... -
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