- Immunohistochemical and SSCP analysis of p53 in malignant lymphomas
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Park CK, Lee JD
- KMID: 1038162
- J Korean Med Sci.
- 1998 Aug;13(4):361-368.
- doi: 10.3346/jkms.1998.13.4.361
We immunohistochemically investigated Epstein-Barr virus (EBV)-positive and negative 31 malignant lymphomas (MLs) for p53 protein using a monoclonal antibody which is expressed on a wild type and mutant human... -
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- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas
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Cho H, Ha SY, Park SH, Park K, Chae YS
- KMID: 648081
- J Korean Med Sci.
- 1999 Apr;14(2):199-205.
- doi: 10.3346/jkms.1999.14.2.199
The mutations that occur in the p53 tumor suppressor gene have been studied in various human malignant tumors. However, little is known about this gene in meningiomas. To investigate the... -
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- Expression of p53 protein in rheumatoid arthritis synovium. An immunohistochemical analysis
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Lee YH, Ji JD, Kim A, Kim CH, Song GG
- KMID: 759085
- Korean J Intern Med.
- 1999 Jan;14(1):59-65.
OBJECTIVES: Mutation of p53 may play a role in manifestation of rheumatoid arthritis synovium, but several studies on p53 expression in synovial tissues of rheumatoid arthritis showed conflicting... -
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- p53 protein expression and its prognostic importance in patients with nodal non-Hodgkin's lymphoma
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Ahn MJ, Kim H, Kim IS, Park JK, Ki MR, Park CK
- KMID: 1731235
- J Korean Med Sci.
- 2000 Feb;15(1):59-64.
- doi: 10.3346/jkms.2000.15.1.59
To determine whether the p53 expression might be a predictor for treatment sponse and overall survival in nodal non-Hodgkin's lymphoma (NHL), we analyzed e expression of p53 in 69 NHL... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- p53 mutation in patients with ulcerative colitis in rectal biopsy
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Kim HJ, Chang SK
- KMID: 759070
- Korean J Intern Med.
- 1998 Jul;13(2):110-116.
OBJECTIVES: Long standing ulcerative colitis (UC) has been known to be one of the precancerous diseases of colorectal cancer. Although the frequent loss of p53 allele (LOH) and aneuploidy were... -
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- p53 codon 72 polymorphism and risk of cervical carcinoma in Korean women
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Baek WK, Cho JW, Suh SI, Suh MH, Shin DH, Cho CH, Lee TS, Cha SD
- KMID: 1731236
- J Korean Med Sci.
- 2000 Feb;15(1):65-67.
- doi: 10.3346/jkms.2000.15.1.65
A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro). A recent... -
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- Detecting p53 gene mutation of breast cancer and defining differences between silver staining PCR-SSCP and immunohistochemical staining
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Ryu JW, Lee MC, Jang WC
- KMID: 1731238
- J Korean Med Sci.
- 2000 Feb;15(1):73-77.
- doi: 10.3346/jkms.2000.15.1.73
This study detects and defines the patterns of p53 gene mutations in breast cancers. We analyse p53 gene mutations through comparing the results of single-strand-conformation-polymorphism (SSCP) and immunohistochemistry (IHC), and... -
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- Mutations of p53 Tumor Suppressor Gene in Spontaneous Canine Mammary Tumors
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Lee CH, Kweon OK
- KMID: 1097349
- J Vet Sci.
- 2002 Dec;3(4):321-325.
Mutation of the p53 tumor suppressor gene has been related in the pathogenesis of numerous human and canine cancers, including breast cancers and mammary tumors. We have investigated exons 5-8... -
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- Prognostic Significance of p21 and p53 Expression in Gastric Cancer
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Seo YH, Joo YE, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 1106143
- Korean J Intern Med.
- 2003 Jun;18(2):98-103.
BACKGROUND: Cyclin-dependent kinase inhibitors (CDKI), including p21, p27 and p57 of the KIP family, are negative regulators of cell cycle progression and potentially act as tumor suppressors. The expression of... -
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- Increased serum levels of mutant p53 proteins in patients with colorectal cancer
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Shim KS, Kim KH, Park BW, Lee SY, Choi JH, Han WS, Park EB
- KMID: 1107225
- J Korean Med Sci.
- 1998 Feb;13(1):44-48.
- doi: 10.3346/jkms.1998.13.1.44
We have examined the serum levels of the mutant p53 protein in patients with colorectal cancer preoperatively (n=50), and in patients with adenomatous polyp (n=13). Mutant p53 protein in patients... -
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- Combination treatment for osteosarcoma with baculoviral vector mediated gene therapy (p53) and chemotherapy (adriamycin)
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Song SU, Boyce FM
- KMID: 755117
- Exp Mol Med.
- 2001 Mar;33(1):46-53.
The insect baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been evaluated as a vector for gene delivery to human tumor cells. A human osteogenic sarcoma cell line, Saos-2,... -
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- p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach
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Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH
- KMID: 1109757
- J Korean Med Sci.
- 2002 Aug;17(4):490-496.
- doi: 10.3346/jkms.2002.17.4.490
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)... -
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- Topographic expression of p21WAF1/SDI1/CIP1, bcl2, and p53 is altered at the early stage of colorectal carcinogenesis
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Cho JH, Roe IH, Lim CY, Park DK, Kim WH, Kim YI
- KMID: 2157547
- J Korean Med Sci.
- 2000 Dec;15(6):667-674.
- doi: 10.3346/jkms.2000.15.6.667
We analyzed the expression of p21, bcl2, and p53 in normal and different pathologic mucosa of the human colorectum using immunohistochemistry and cold polymerase chain reaction-single strand conformation polymorphism. The topography... -
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- Transcription repression of a CCAAT-binding transcription factor CBF/HSP70 by p53
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Chae HD, Yun J, Shi D
- KMID: 1089459
- Exp Mol Med.
- 2005 Oct;37(5):488-491.
NF-Y transcription factor binds to CCAAT boxes on promoters of cell cycle regulatory genes such as cdc2, cyclin B, cdc25C, and cyclin A. We previously reported that the DNA binding... -
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- p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells
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Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters
- KMID: 1457532
- Exp Mol Med.
- 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1... -
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- Functional characterization of human oncoprotein gankyrin in Zebrafish
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Kim SY, Hur W, Choi JE, Kim D, Wang JS, Yoon HY, Piao LS, Yoon SK
- KMID: 756281
- Exp Mol Med.
- 2009 Jan;41(1):8-16.
- doi: 10.3858/emm.2009.41.1.002
Gankyrin is an oncoprotein containing seven ankyrin repeats that is overexpressed in hepatocellular carcinoma (HCC). Gankyrin binds to Mdm2, which results in accelerated ubiquitylation via degradation of p53, and it... -
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- Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas
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Nam DH, Song SY, Park KS, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH
- KMID: 938873
- Exp Mol Med.
- 2001 Sep;33(3):111-116.
Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11... -
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- Development of a packaging cell line for propagation of replication-deficient adenovirus vector
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Kim JS, Lee SH, Cho YS, Park KS, Kim YH, Lee JH
- KMID: 938878
- Exp Mol Med.
- 2001 Sep;33(3):145-149.
A human embryonic kidney cell line 293 is widely used for adenovirus production and propagation. With this cell line, however, replication-competent virus (RCV) is frequently generated, especially during large-scale production... -
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