- Patterns of p53 expression in phyllodes tumors of the breast: an immunohistochemical study
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Kim CJ, Kim WH
- KMID: 1421998
- J Korean Med Sci.
- 1993 Oct;8(5):325-328.
- doi: 10.3346/jkms.1993.8.5.325
Authors performed an immunohistochemical analysis using monoclonal antibody to p53 protein on 15 cases of benign and malignant phyllodes tumor of the breast along with a review of other conventional... -
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- Over-expression of p53 protein in squamous cell carcinoma of the skin
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Rhim KJ, Hong SI, Lee DS, Park IC, Lee SY, Jang JJ
- KMID: 1129863
- J Korean Med Sci.
- 1995 Feb;10(1):36-41.
- doi: 10.3346/jkms.1995.10.1.36
p53 gene mutations have been known to be highly related to the particular stage of transformation in various types of human cancers. This study was conducted to investigate the p53... -
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- Aberrant expression of p53 gene product in malignant melanoma
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Rhim KJ, Hong SI, Hong WS, Lee SY, Lee DS, Jang JJ
- KMID: 644824
- J Korean Med Sci.
- 1994 Oct;9(5):376-381.
- doi: 10.3346/jkms.1994.9.5.376
According to the current concept of carcinogenesis, the alterations of p53 tumor suppressor gene have been the most frequently detected in both human cancer cell lines and cancer tissues freshly... -
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- Expressions of p53 and p21 in Primary Gastric Lymphomas
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Go JH, Yang WI
- KMID: 648353
- J Korean Med Sci.
- 2001 Dec;16(6):731-735.
- doi: 10.3346/jkms.2001.16.6.731
The p21 overexpression is thought to be a consequence of the p53 induced activation of the p21 gene. The immunohistochemical evaluation of p53 and p21 can be a valuable means... -
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- The prognostic significance of c-erbB-2 and p53 protein expressions in gastric carcinoma: a multivariate analysis of prognostic factors
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Kim JP, Oh ST, Hwang TS, Chi JG
- KMID: 644803
- J Korean Med Sci.
- 1994 Jun;9(3):248-253.
- doi: 10.3346/jkms.1994.9.3.248
152 curative gastrectomy specimens from patients with gastric carcinoma were examined in an attempt to assess the prognostic value of c-erbB-2 and mutant p53 protein expressions. The labeled streptavidin-biotin method... -
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- p53 protein expression in extrahepatic bile duct cancer
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Lee YC, Song SY, Chung JB, Kang JK, Park IS
- KMID: 2069427
- Yonsei Med J.
- 1996 Apr;37(2):112-117.
- doi: 10.3349/ymj.1996.37.2.112
p53 mutations, a tumor suppressor gene located on chromosome 17p, are the most common genetic alterations found in human cancers. Although the p53 expression or mutation has been investigated in... -
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- Immunohistochemical detection of p53 protein, c-erbB-2 protein, epidermal growth factor receptor protein and proliferating cell nuclear antigen in gastric carcinoma
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Jang WI, Yang WI, Lee CI, Kim HS, Song KS, Cho MY, Park JK, Shim YH
- KMID: 2157514
- J Korean Med Sci.
- 1993 Aug;8(4):293-304.
- doi: 10.3346/jkms.1993.8.4.293
There is increasing evidence that genes involved in normal cell growth and differentiation (oncogenes) or genes that encode for growth factors are important in determining the development and biologic aggressiveness... -
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- An immunohistochemical study of the expression of p53 protein in colon cancer
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Kim YW, Lee S, Park JH, Yoon TY, Park YK, Yang MH
- KMID: 1054341
- J Korean Med Sci.
- 1995 Jun;10(3):176-182.
- doi: 10.3346/jkms.1995.10.3.176
A total of 471 cases of colonic adenocarcinomas and 28 cases of colonic adenomas were examined immunohistochemically to evaluate the expression of p53 protein in the light of their relationship... -
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- Immunohistochemical analysis of p53 protein expression in benign and malignant skin tumors using a panel of anti-p53 antibodies
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Ro YS, Kim JH
- KMID: 1422004
- J Korean Med Sci.
- 1993 Oct;8(5):361-366.
- doi: 10.3346/jkms.1993.8.5.361
The expression of p53 in a variety of benign and malignant skin lesions has been first assessed in frozen sections and then compared with the results obtained in corresponding paraffin-embedded... -
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- Clinical Significance of p16 Protein Expression Loss and Aberrant p53 Protein Expression in Pancreatic Cancer
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Jeong J, Park YN, Park JS, Yoon DS, Chi HS, Kim BR
- KMID: 1716522
- Yonsei Med J.
- 2005 Aug;46(4):519-525.
- doi: 10.3349/ymj.2005.46.4.519
Pancreatic cancer is a disease with poor prognosis mainly due to low resection rates and late diagnosis. To increase resectability and improve survival rates, a better understanding of pancreatic cancer... -
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- Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone
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Park HR, Park YK
- KMID: 644902
- J Korean Med Sci.
- 1995 Oct;10(5):360-367.
- doi: 10.3346/jkms.1995.10.5.360
Expressions of p53 protein, a product of the tumor suppressor gene were studied in osteosarcomas relating to various prognostic factors. Thirty-four osteosarcomas were investigated immunohistochemically with a monoclonal antibody clone... -
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- Expression of the G1-S Modulators in Hepatitis B Virus-Related Hepatocellular Carcinoma and Dysplastic Nodule: Association of Cyclin D1 and p53 Proteins with the Progression of Hepatocellular Carcinoma
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Choi YL, Park SH, Jang JJ, Park CK
- KMID: 648300
- J Korean Med Sci.
- 2001 Aug;16(4):424-432.
- doi: 10.3346/jkms.2001.16.4.424
Deranged expression of cell cycle modulators has been reported to contribute to the development and progression of hepatocellular carcinoma (HCC). However, their expression patterns remain poorly understood in hepatitis B... -
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- The Relationship between Microvessel Count and the Expression of Vascular Endothelial Growth Factor, p53, and K-ras in Non-Small Cell Lung Cancer
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Kang YH, Kim KS, Yu YK, Lim SC, Kim YC, Park KO
- KMID: 648299
- J Korean Med Sci.
- 2001 Aug;16(4):417-423.
- doi: 10.3346/jkms.2001.16.4.417
Using immunohistochemical staining, we studied the relationship between the microvessel count (MC) and the expression of K-ras, mutant p53 protein, and vascular endothelial growth factor (VEGF) in 61 surgically resected... -
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- Cyclo-oxygenase-2 and p53 Immunoreactivity in Superficial Early Colorectal Carcinoma
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Kim YS, Lim SD, Lee JK, Kim SE, Ryu SH, Lee JW, Moon JS
- KMID: 772954
- Korean J Gastroenterol.
- 2006 May;47(5):350-356.
BACKGROUND/AIMS: De novo colorectal carcinoma shows more aggressive behavior including submucosal invasiveness. Both p53 and cyclo-oxygenase-2 (COX-2) have been shown to be involved in colon carcinogenesis, progression from adenoma to... -
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- Expression of Cyclooxygenase-2, p53 and Ki-67 in Gastric Cancer
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Joo YE, Chung IJ, Park YK, Koh YS, Lee JH, Park CH, Lee WS, Kim HS, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 1781908
- J Korean Med Sci.
- 2006 Oct;21(5):871-876.
- doi: 10.3346/jkms.2006.21.5.871
It has been reported that p53 mutation may contribute to upregulate cyclooxygenase (COX)-2 expression that is observed in malignant tissues. These molecules are involved in carcinogenesis by affecting tumor cell... -
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- Cyclin E, p27 and Mutant p53 do not Predict the Prognosis in AJCC Stage II Colorectal Carcinomas
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Lim YJ, Kim YH, Ahn GH, Chun HK, Jang WY, Lee JH, Son HJ, Rhee PL, Kim JJ, Paik SW, Yoo BC, Rhee JC
- KMID: 772703
- Korean J Gastroenterol.
- 2004 Dec;44(6):314-320.
BACKGROUND/AIMS: Carcinogenesis is characterized by the abnormal regulation of cell cycle. The abnormal expression of the regulators of cell cycle may be related to the prognosis. Since the clinical... -
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- Clinicopathological Features and Differences of p53 and Ki-67 Expression in Adenosquamous and Squamous Cell Carcinomas of the Stomach
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Kim YS, Heo WS, Chae KH, Gang YS, Jung JH, Kim SH, Seong JK, Lee BS, Jeong HY, Song KS, Shin KS, Cho JS, Noh SM
- KMID: 772969
- Korean J Gastroenterol.
- 2006 Jun;47(6):425-431.
BACKGROUND/AIMS: This study reviewes the clinicopathological features, prognosis, and differences in the expression of p53 and Ki-67 immunochemical staining in squamous cell and adenosquamous carcinoma of the stomach. ... -
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