- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
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Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
- KMID: 1111411
- Exp Mol Med.
- 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the... -
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- Effects of sevoflurane on tight junction protein expression and PKC-alpha translocation after pulmonary ischemia-reperfusion injury
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Chai J, Long B, Liu X, Li Y, Han N, Zhao P, Chen W
- KMID: 2155421
- Exp Mol Med.
- 2015 Jun;47(6):e167.
- doi: 10.1038/emm.2015.27
Pulmonary dysfunction caused by ischemia-reperfusion injury is the leading cause of mortality in lung transplantation. We aimed to investigate the effects of sevoflurane pretreatment on lung permeability, tight junction protein... -
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- Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells
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Park SN, Noh KT, Jeong YI, Jung ID, Kang HK, Cha GS, Lee SJ, Seo JK, Kang DH, Hwang TH, Lee EK, Kwon B, Park YM
- KMID: 2154227
- Exp Mol Med.
- 2013 Feb;45(2):e8.
We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin... -
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- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells
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Jung EJ, Kim CW, Kim DR
- KMID: 756329
- Exp Mol Med.
- 2008 Jun;40(3):276-285.
- doi: 10.3858/emm.2008.40.3.276
Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On... -
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- Epigallocatechin-3-gallate Suppresses Galactose-alpha1,4-galactose-beta1,4-glucose Ceramide Expression in TNF-alpha Stimulated Human Intestinal Epithelial Cells Through Inhibition of MAPKs and NF-kappa B
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Moon DO, Choi SR, Lee CM, Kim GY, Lee HJ, Park YM
- KMID: 1712731
- J Korean Med Sci.
- 2005 Aug;20(4):548-554.
- doi: 10.3346/jkms.2005.20.4.548
Intestinal epithelial cells (IECs) have been known to produce galactose-alpha1,4-galactose-beta1,4-glucose ceramide (Gb3) that play an important role in the mucosal immune response. The regulation of Gb3 is important to prevent... -
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- Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein
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Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ
- KMID: 2154241
- Exp Mol Med.
- 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in... -
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- Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-kappaB-dependent cFLIP expression in HeLa cells
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Seo OW, Kim JH, Lee KS, Lee KS, Kim JH, Won MH, Ha KS, Kwon YG, Kim YM
- KMID: 1401757
- Exp Mol Med.
- 2012 Nov;44(11):653-664.
This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism. A low dose of kurarinone had... -
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- Corn silk induces nitric oxide synthase in murine macrophages
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Kim KA, Choi SK, Choi HS
- KMID: 1103321
- Exp Mol Med.
- 2004 Dec;36(6):545-550.
Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric... -
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- 2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes
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Yu SM, Kim HA, Kim SJ
- KMID: 1104210
- Exp Mol Med.
- 2010 Jul;42(7):503-513.
- doi: 10.3858/emm.2010.42.7.051
2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the... -
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- Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells
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Kim J, Choi BH, Jang KL, Min DS
- KMID: 1123766
- Exp Mol Med.
- 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast... -
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- Iron chelator inducesMIP-3alpha/CCL20 in human intestinal epithelial cells: implication for triggeringmucosal adaptive immunity
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Lee HJ, Choi SC, Choi EY, Lee MH, Seo GS, Kim EC, Yang BJ, Lee MS, Shin YI, Park KI, Jun CD
- KMID: 1093465
- Exp Mol Med.
- 2005 Aug;37(4):297-310.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs). Microarray-based gene... -
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- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
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Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
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