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The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells

Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB

  • KMID: 2070111
  • Korean J Intern Med.
  • 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of...
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Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration

Kwon HJ, Hong SK, Yoon WK, Nam KH, Choi IP, Kim DY, Kim HC, Won YS

Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1...
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Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury

Song J, Cho KJ, Cheon SY, Kim SH, Park KA, Lee WT, Lee JE

  • KMID: 2154288
  • Exp Mol Med.
  • 2013 Dec;45(12):e69.
Neural stem cells (NSCs) have been suggested as a groundbreaking solution for stroke patients because they have the potential for self-renewal and differentiation into neurons. The differentiation of NSCs into...
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JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Cho IH, Lee KW, Ha HY, Han PL

We previously reported that mice lacking JSAP1 (jsap1-/-) were lethal and the brain of jsap1-/- at E18.5 exhibited multiple types of developmental defects, which included impaired axon projection of the...
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Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species

Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK

Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen...
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Aldosterone Modulates Cell Proliferation and Apoptosis in the Neonatal Rat Heart

Sohn HJ, Yoo KH, Jang GY, Lee JH, Choi BM, Lee JH, Bae IS, Yim HE, Son CS, Lee JW

In the present study, we investigated whether and how the mineralocorticoid receptor antagonist spironolactone affects cardiac growth and development through apoptosis and cell proliferation in the neonatal rat heart. Newborn...
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Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change

Roh SA, Choi EY, Cho DH, Jang SJ, Kim SY, Kim YS, Kim JC

Integrative genetic changes were examined in relation to tumor growth and progression of sporadic colorectal cancers. Ninety-two sporadic colorectal cancer patients and 12 human colorectal cancer cell lines were evaluated....
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Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis

Yoon YS, Ryu D, Lee MW, Hong S, Koo SH

During fasting periods, hepatic glucose production is enhanced by glucagon to provide fuels for other organs. This process is mediated via cAMP-dependent induction of the CREB regulated transcriptional coactivator (CRTC)...
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Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media

Lee YS, Lan Tran H, Van Ta Q

Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt...
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Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts

Jang IS, Rhim JH, Park SC, Yeo EJ

  • KMID: 1111406
  • Exp Mol Med.
  • 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid...
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The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways

Shin SY, Lee JH, Min B, Lee YH

  • KMID: 1115946
  • Exp Mol Med.
  • 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated...
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Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha

Jang IS, Juhnn YS

  • KMID: 755116
  • Exp Mol Med.
  • 2001 Mar;33(1):37-45.
Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein...
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