- AMP-activated protein kinase as a key molecular link between metabolism and clockwork
-
Lee Y, Kim EK
- KMID: 2154252
- Exp Mol Med.
- 2013 Jul;45(7):e33.
Circadian clocks regulate behavioral, physiological and biochemical processes in a day/night cycle. Circadian oscillators have an essential role in the coordination of physiological processes with the cyclic changes in the... -
- CITED
-
- Close
- SHARE
-
- Close
- Exposure to Cerium Oxide Nanoparticles Is Associated With Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs
-
Rice KM, Nalabotu S, Manne ND, Kolli MB, Nandyala G, Arvapalli , Ma JY, Blough ER
- KMID: 2381462
- J Prev Med Public Health.
- 2015 May;48(3):132-141.
- doi: 10.3961/jpmph.15.006
OBJECTIVES: With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of Down Stream Molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in Papillary Thyroid Carcinomas
-
Shin E, Hong SW, Kim SH, Yang WI
- KMID: 2428328
- Yonsei Med J.
- 2004 Apr;45(2):306-313.
To evaluate the roles of 4 putative downstream molecules (ERK, p38 MAPK, JNK and AKT) of the RET signal pathway in the tumorigenesis of papillary carcinomas, the expression patterns of... -
- CITED
-
- Close
- SHARE
-
- Close
- Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression
-
Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C
- KMID: 1094665
- Exp Mol Med.
- 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated... -
- CITED
-
- Close
- SHARE
-
- Close
- Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
-
Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY
- KMID: 1372805
- J Korean Med Sci.
- 2012 May;27(5):572-575.
- doi: 10.3346/jkms.2012.27.5.572
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of... -
- CITED
-
- Close
- SHARE
-
- Close
- Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1
-
Kim WY, Jang JY, Jeon YK, Chung DH, Kim YG, Kim CW
- KMID: 2155355
- Exp Mol Med.
- 2014 Apr;46(4):e90.
- doi: 10.1038/emm.2014.1
Syntenin is a PDZ domain-containing adaptor protein that has been recently shown to regulate migration and invasion in several tumors. Small cell lung cancer (SCLC) is notorious for its invasiveness... -
- CITED
-
- Close
- SHARE
-
- Close
- Increased phosphorylation of c-Jun NH (2)-terminal protein kinase in the sciatic nerves of Lewis rats with experimental autoimmune neuritis
-
Ahn M, Shin T
- KMID: 1103547
- J Vet Sci.
- 2006 Mar;7(1):13-17.
- doi: 10.4142/jvs.2006.7.1.13
The phosphorylation of c-Jun NH (2)-terminal protein kinase (JNK), one of the mitogen-activated protein kinases, was analyzed in the sciatic nerves of Lewis rats with experimental autoimmune neuritis (EAN). Western... -
- CITED
-
- Close
- SHARE
-
- Close
- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
-
Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
- CITED
-
- Close
- SHARE
-
- Close
- Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure
-
Jeon SH, Kim YS, Bae CD, Park JB
- KMID: 755104
- Exp Mol Med.
- 2000 Dec;32(4):227-230.
Kainic acid, an analogue of glutamate, causes limbic seizures and induces cell death in the rat brain. We examined the activation of MAPK family kinases; ERKs, JNKs and... -
- CITED
-
- Close
- SHARE
-
- Close
- Involvement of MAP Kinases in Apoptosis of Macrophage Treated with Trichomonas vaginalis
-
Ryang YS, Chang JH, Park JY
- KMID: 721432
- Yonsei Med J.
- 2004 Aug;45(4):751-754.
- doi: 10.3349/ymj.2004.45.4.751
A primitive protozoan parasite Trichomonas vaginalis selectively activates the signal transduction pathways in macrophages (RAW264.7). This study evaluated the correlation of these signaling pathways and T. vaginalis-induced cell apoptosis. In... -
- CITED
-
- Close
- SHARE
-
- Close
- Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK
-
Ha YJ, Seul HJ, Lee JR
- KMID: 1097267
- Exp Mol Med.
- 2011 Feb;43(2):101-110.
- doi: 10.3858/emm.2011.43.2.012
Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K)... -
- CITED
-
- Close
- SHARE
-
- Close
- p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
-
Ko J, Yun CY, Lee JS, Kim JH, Kim IS
- KMID: 1094653
- Exp Mol Med.
- 2007 Apr;39(2):129-138.
9-cis-retinoic acid (9CRA) plays an important role in the immune response; this includes cytokine production and cell migration. We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1... -
- CITED
-
- Close
- SHARE
-
- Close
- Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif
-
Kim MA, Kim HJ, Brown AL, Lee MY, Bae YS, Park JI, Kwak JY, Chung JH, Yun J
- KMID: 1094661
- Exp Mol Med.
- 2007 Apr;39(2):205-212.
Checkpoint kinase 1 (Chk1) and Chk2 are effector kinases in the cellular DNA damage response and impairment of their function is closely related to tumorigenesis. Previous studies revealed several substrate... -
- CITED
-
- Close
- SHARE
-
- Close
- 14-3-3epsilon protein increases matrix metalloproteinase-2 gene expression via p38 MAPK signaling in NIH3T3 fibroblast cells
-
Lee EK, Lee YS, Lee H, Choi CY, Park SH
- KMID: 1058019
- Exp Mol Med.
- 2009 Jul;41(7):453-461.
- doi: 10.3858/emm.2009.41.7.050
One of the 14-3-3 protein isoforms, 14-3-3epsilon, was previously shown to be increased during skin aging. We suggest here a possible role for the 14-3-3epsilon protein in skin aging by... -
- CITED
-
- Close
- SHARE
-
- Close
- Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4
-
Lee KH, Choi EY, Hyun MS, Kim JR
- KMID: 755666
- Exp Mol Med.
- 2004 Feb;36(1):57-64.
Clinical studies have shown that tumor hypoxia is associated with invasive growth and metastasis and may be an important prognostic factor adversely influencing survival in patients with tumors. To investigate... -
- CITED
-
- Close
- SHARE
-
- Close
- Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas
-
Lee H
- KMID: 1093618
- Exp Mol Med.
- 2003 Oct;35(5):448-453.
Breast cancer susceptibility gene, BRCA2, is a tumor suppressor and individuals who inherit one defected copy of BRCA2 allele experience early onset breast cancer or ovarian cancer accompanied by the... -
- CITED
-
- Close
- SHARE
-
- Close
- Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
-
Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG
- KMID: 1105280
- Exp Mol Med.
- 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,... -
- CITED
-
- Close
- SHARE
-
- Close
- Prologation of c-Jun N-Terminal Kinase is Associated with Cell Death Induced by Tumor Necrosis Factor Alpha in Human Chondrocytes
-
Yoon HS, Kim HA
- KMID: 2157687
- J Korean Med Sci.
- 2004 Aug;19(4):567-573.
- doi: 10.3346/jkms.2004.19.4.567
The aim of this study was to elucidate the role of JNK signaling pathway involved in tumor necrosis factor-alpha (TNF-alpha)-induced death of chondrocytes. Primary chondrocyte cultures were obtained from human... -
- CITED
-
- Close
- SHARE
-
- Close
- Activation of MAPK Is Required for ROS Generation and Exocytosis in HMC-1 Cells Induced by Trichomonas vaginalis-Derived Secretory Products
-
Narantsogt G, Min A, Nam YH, Lee YA, Kim KA, Agvaandaram G, Dorjsuren , El-Benna J, Shin MH
- KMID: 2381782
- Korean J Parasitol.
- 2015 Oct;53(5):597-603.
- doi: 10.3347/kjp.2015.53.5.597
Trichomonas vaginalis is a flagellated protozoan parasite that causes vaginitis and cervicitis in women and asymptomatic urethritis and prostatitis in men. Mast cells have been reported to be predominant in... -
- CITED
-
- Close
- SHARE
-
- Close
- The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
-
Park S, Lim S, Chang W, Song H, Lee S, Song BW, Kim HJ, Cha MJ, Choi E, Jang Y, Chung N, Cho SY, Hwang KC
- KMID: 1793194
- Yonsei Med J.
- 2008 Aug;49(4):592-600.
- doi: 10.3349/ymj.2008.49.4.592
PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms... -
- CITED
-
- Close
- SHARE
-
- Close
