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Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage

Lee SW, Cho JM, Cho HJ, Kang JY, Kim EK, Yoo TK

PURPOSE: Heat shock protein (HSP) 27 protects the cell by controlling apoptosis and immune reactions, and c-FLIP (cellular-FLICE inhibitory protein) inhibits apoptosis by inhibiting caspase-8 activity. We investigated the relationship...
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Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway

Jee B, Jin K, Hahn JH, Song HG, Lee H

  • KMID: 1088655
  • Exp Mol Med.
  • 2003 Feb;35(1):30-37.
To investigate the functional role of KAI1/CD82, a metastasis suppressor for human prostate cancer, in the regulation of homotypic cell adhesion, we transfected KAI1 cDNA into DU 145 human prostate...
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Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4

Lee KH, Choi EY, Hyun MS, Kim JR

  • KMID: 755666
  • Exp Mol Med.
  • 2004 Feb;36(1):57-64.
Clinical studies have shown that tumor hypoxia is associated with invasive growth and metastasis and may be an important prognostic factor adversely influencing survival in patients with tumors. To investigate...
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