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Enhancement of Transduction Efficiency and Antitumor Effects of IL-12N220L-expressing Adenovirus by Co-delivery of DOTAP

Youn JI, Jin HT, Sung YC

BACKGROUND: Adenovirus (Ad) vectors have been widely used for many gene therapy applications because of their high transduction ability and broad tropism. However, their utility for cancer gene therapy is...
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Decreasing Effect of Lidocaine.HCl on the Thickness of the Neuronal and Model Membrane

Park SM, Park JS, Kim JH, Baek JH, Yoon TG, Lee DK, Ryu WH, Chung IK, Sohn UD, Jang HO, Yun I

This study examined the mechanism of action of a local anesthetic, lidocaine.HCl. Energy transfer between the surface fluorescent probe, 1-anilinonaphthalene-8-sulfonic acid, and the hydrophobic fluorescent probe, 1,3-di(1-pyrenyl) propane, was used...
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Calcification-resistant Effect of Surface-modified Biologic Arteries by Sulfonated Polyethyleneoxide

Kim HM, Baek MJ, Sun K, Lee SY, Lee SA, Kim KT, Lee IS, Lee WG, Park GD, Kim YH

  • KMID: 2288916
  • Korean J Thorac Cardiovasc Surg.
  • 1999 Nov;32(11):989-997.
BACKGROUND: Calcific degeneration is the major cause of clinical failure of glutaraldehyde (GA) crosslinked bioprosthetic tissues implanted in the body and necessitates the reoperation or causes death. Surface modification of...
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In vitro cytotoxicity of novel platinum(II) coordination complexes containing diaminocyclohexane and diphenylphosphines

Jung JC, Kim YK, Park SJ, Chung JH, Chang SG, Lee KT, Baek MS, Park JJ, Rho YS

  • KMID: 1849848
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):395-401.
We have synthesized new platinum(H) analogs containing 1,2-diaminocyclohexane (dach) as a carrier ligand, 1,3-bis(diphenylphosphino) propane (DPPP) /1,2-bis(diphenylphosphino)ethane (DPPE) as a leaving group and nitrates to improve solubility. In the present study, the cytotoxicity of (Pt(trans-l-dach)(DPPP))cntdot2NO3...
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Effects of Chelators on Liver Cadmium Contents in Chronic Cadmium Intoxication Rats

Lee SH, Lee KT, Lee JH, Lee JK, Rhee PL, Kim JJ, Koh KC, Paik SW, Rhee JC, Choi KW

  • KMID: 2241335
  • Korean J Hepatol.
  • 1998 Mar;4(1):59-68.
BACKGROUND/AIMS: The heavy metals like cadmium (Cd) are neither destroyed nor produced in human body and may infiltrated into air, water, soil, food, human body and redistributed by biological and geographical circulation....
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Anti-Cancer Effect of 3-(4-dimethylamino phenyl)-N-hydroxy-2-propenamide in MCF-7 Human Breast Cancer

Min KN, Joung KE, Kim DK, Sheen YY

  • KMID: 2380177
  • Environ Health Toxicol.
  • 2012 ;27(1):e2012010.
OBJECTIVES: In recent years, a number of structurally diverse Histone deacetylase (HDAC) inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in...
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Comparative Evaluation of Cyclopropane and Fluothane Anesthesia During Hemorrhagie Shock in Dogs

Kwak IY, Kim KW, Kim YL

In order to comparatively evaluate the effects of cyclopropane and fluothane upon mean arterial pressure. cardiac output and splanchnic blood flow during hemorrhagic shock a Iaboratory investigation was conducted in...
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