- A Study of Polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) Promoter Gene in Korean Patients with Gilbert's Syndrome
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Kim YH, Yeon JE, Jung GM, Kim HJ, Kim JS, Byun KS, Bak YT, Lee CH
- KMID: 1123162
- Korean J Hepatol.
- 2002 Jun;8(2):132-138.
BACKGROUNDS/AIMS: Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal in patients with Gilbert's syndrome. Patients with Gilbert's syndrome have an... -
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- Association between interleukin 6 promoter variants and chronic hepatitis B progression
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Park BL, Lee HS, Kim YJ, Kim JY, Jung JH, Kim LH, Shin HD
- KMID: 1097254
- Exp Mol Med.
- 2003 Apr;35(2):76-82.
Interleukin 6 (IL6) plays an essential role in the regulation of immune response to chronic disease. In this study, the three known single nucleotide polymorphisms (SNPs) in the IL6 promoter... -
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- Association of TNFA Promoter Region Haplotype in Behcet's Disease
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Park KS, Kim NY, Nam JH, Bang D, Lee ES
- KMID: 2157807
- J Korean Med Sci.
- 2006 Aug;21(4):596-601.
- doi: 10.3346/jkms.2006.21.4.596
Although the etiology of Behcet's Disease (BD; MIM 109650) remains to be clearly elucidated, levels of tumor necrosis factor alpha (TNF-alpha) have been reported to be significantly elevated in BD... -
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- Analysis of the Monocyte Chemoattractant Protein 1 -2518 Promoter Polymorphism in Korean Patients with Alopecia Areata
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Hong SB, Jin SY, Park HJ, Jung JH, Sim WY
- KMID: 2157789
- J Korean Med Sci.
- 2006 Feb;21(1):90-94.
- doi: 10.3346/jkms.2006.21.1.90
Monocyte chemoattractant protein-1 (MCP-1) levels are increased in scalp lesions of patients with alopecia areata (AA), suggesting a role in the development of AA. Recently, a biallelic A/G polymorphism in... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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- The Prevalence and Clinical Significance of Precore and Core Promoter Mutations in Korean Patients with hronic Hepatitis B Virus Infection
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Kim HJ, Yoo BC
- KMID: 1123164
- Korean J Hepatol.
- 2002 Jun;8(2):149-156.
BACKGROUND/AIMS: Precore and core promoter mutations of hepatitis B virus (HBV) have been reported in Korea but their prevalence and clinical significance have not been determined. The aims of this... -
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- Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance
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Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS, Shin HD
- KMID: 1115948
- Exp Mol Med.
- 2006 Dec;38(6):694-702.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the... -
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- Association between CCR5 Promoter Polymorphisms and Hepatitis B Virus Infection
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Chang HY, Ahn SH, Kim DY, Shin JS, Kim YS, Hong SP, Chung HJ, Kim SO, Yoo WD, Han KH
- KMID: 760589
- Korean J Hepatol.
- 2005 Jun;11(2):116-124.
BACKGROUND/AIMS: Immunogenetic factors may play a role in determining the susceptibility of an individual to viral infection. CCR5 promoter polymorphisms are known to be associated with HIV infection. However,... -
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- Polymorphism of Matrix Metalloproteinase-3 Promoter Gene as a Risk Factor for Coronary Artery Lesions in Kawasaki Disease
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Park JA, Shin KS, Kim YW
- KMID: 1712741
- J Korean Med Sci.
- 2005 Aug;20(4):607-611.
- doi: 10.3346/jkms.2005.20.4.607
Kawasaki disease (KD) is a major cause of acquired coronary artery diseases in childhood. The serum levels of matrix metalloproteinase (MMP)-3 and MMP-9 in KD have been reported to be... -
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- Efficient gene delivery in differentiated human embryonic stem cells
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Kim JH, Do HJ, Choi SJ, Cho HJ, Park KH, Yang HM, Lee SH, Kim DK, Kwack K, Oh SK, Moon SY, Cha KY, Chung HM
- KMID: 1033099
- Exp Mol Med.
- 2005 Feb;37(1):36-44.
Human embryonic stem (hES) cells are capable of differentiating into pluralistic cell types, however, spontaneous differentiation generally gives rise to a limited number of specific differentiated cell types and a... -
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