- A Polymorphism of the Renin Gene rs6682082 Is Associated with Essential Hypertension Risk and Blood Pressure Levels in Korean Women
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Park J, Song K, Jang Y, Kim Yoon S
- KMID: 2352811
- Yonsei Med J.
- 2015 Jan;56(1):227-234.
- doi: 10.3349/ymj.2015.56.1.227
PURPOSE: The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans. MATERIALS AND... -
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- Expression of Exogenous Human Hepatic Nuclear Factor-1alpha by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2
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Liao S, Liu Y, Zheng B, Cho PY, Song HO, Lee YS, Jung SY, Park H
- KMID: 1715752
- Korean J Parasitol.
- 2011 Dec;49(4):431-436.
- doi: 10.3347/kjp.2011.49.4.431
The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors as well as by individual host responses to these determinants. In both humans and mice,... -
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- Effect of the fourth nucleotide at the 3′ end of neuraminidase and matrix viral genomic RNA on the pathogenicity of influenza virus A/PR/8/34
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Lee CY, Kwon HJ, Nguyen TT, Kim I, Jang HK, Kim JH
- KMID: 2412555
- J Vet Sci.
- 2017 Aug;18(S1):307-313.
- doi: 10.4142/jvs.2017.18.S1.307
Twelve nucleotides located at the 3′ end of viral genomic RNA (vRNA) are conserved among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid reverse genetics vector system... -
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- Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population
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Jin EH, Lee SI, Kim J, Seo EY, Lee SY, Hur GM, Shin S, Hong JH
- KMID: 2164496
- J Korean Med Sci.
- 2015 Aug;30(8):1035-1041.
- doi: 10.3346/jkms.2015.30.8.1035
Gastric cancer is one of the most common cancers in the world. The aims of this study were to evaluate the association between polymorphisms in TFF gene family, TFF1, TFF2,... -
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- Polymorphism in the promoter region of the klotho gene (G-395A) is associated with early dysfunction in vascular access in hemodialysis patients
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Kim Y, Jeong SJ, Lee HS, Kim EJ, Song YR, Kim SG, Oh JE, Lee YK, Seo JW, Yoon JW, Koo JR, Kim HJ, Noh JW, Park SH
- KMID: 1100768
- Korean J Intern Med.
- 2008 Dec;23(4):201-207.
- doi: 10.3904/kjim.2008.23.4.201
BACKGROUND/AIMS: Vascular access dysfunction is an important cause of morbidity and mortality in hemodialysis (HD) patients. Recent studies have shown that a klotho gene mutation is related to endothelial... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells
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Kang DW, Min G, Park DY, Hong KW, Min DS
- KMID: 1104382
- Exp Mol Med.
- 2010 Aug;42(8):555-564.
- doi: 10.3858/emm.2010.42.8.056
Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed... -
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- Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability
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Lee W, Choi HI, Kim MJ, Park SY
- KMID: 1103594
- Exp Mol Med.
- 2008 Feb;40(1):109-117.
- doi: 10.3858/emm.2008.40.1.109
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not... -
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- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
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Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
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- Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells
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Lee KM, Seo HY, Kim MK, Min AK, Ryu SY, Kim YN, Park YJ, Choi HS, Lee KU, Park WJ, Park KG, Lee IK
- KMID: 946666
- Exp Mol Med.
- 2010 Jan;42(1):21-29.
- doi: 10.3858/emm.2010.42.1.002
Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the... -
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- Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer
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Sambuudash O, Kim HS, Cho MY
- KMID: 2419080
- Yonsei Med J.
- 2017 Jul;58(4):749-755.
- doi: 10.3349/ymj.2017.58.4.749
PURPOSE: The molecular nature and the rate-limiting step of epigenetic field defects in the evolution of left-sided colorectal cancer (LCA) remain uncertain. MATERIALS AND METHODS: The methylation status of 27 candidate... -
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- Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells
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Lee YS, Lee EK, Han IO, Park SH
- KMID: 1103587
- Exp Mol Med.
- 2008 Feb;40(1):43-51.
- doi: 10.3858/emm.2008.40.1.43
The inhibitory Smad6 and Smad7 are responsible for cross-talk between TGF-beta/bone morphogenic protein (BMP) signaling and other cellular signaling pathways, as well as negative feedback on their own signaling functions.... -
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- Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
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Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU
- KMID: 2154251
- Exp Mol Med.
- 2013 Jul;45(7):e32.
The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated Toll-like receptors (TLRs). It is unclear,... -
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