- Protective Effect of Probucol against Adriamycin-Induced Apoptosis in Cultured Rat Cardiac Myocytes
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Lee SJ, Lee DS, Jung YW
- KMID: 2207532
- J Korean Pediatr Soc.
- 2000 Jun;43(6):746-754.
PURPOSE: In adriamycin(ADR)-induced cardiomyopathy, several different mechanisms are suggested. However, little information is available regarding the role of apoptosis. In the present study, we examined the induction of apoptosis on... -
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- Effect of Probucol and Verapamil on Injury to Myocardium and Nerve Fibers in Rat Heart Induced by Doxorubicin
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Yi SY, Cho SH, Yang WI
- KMID: 2277692
- Korean J Pathol.
- 2004 Dec;38(6):378-387.
BACKGROUND: Doxorubicin is considered to be one of the most effective drugs to treat a variety of human cancers. However, the dose-dependent cardiotoxicity of doxorubicin limits its clinical usefulness. This... -
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- Synergistic Efficacy of Concurrent Treatment with Cilostazol and Probucol on the Suppression of Reactive Oxygen Species and Inflammatory Markers in Cultured Human Coronary Artery Endothelial Cells
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Park SY, Lee JH, Shin HK, Kim CD, Lee WS, Rhim BY, Shin YW, Hong KW
- KMID: 1838354
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):165-170.
- doi: 10.4196/kjpp.2008.12.4.165
In the present study, we aimed to identify the synergistic effects of concurrent treatment of low concentrations of cilostazol and probucol to inhibit the oxidative stress with suppression of inflammatory... -
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- The Effect of the Probucol-Loaded BiodivYsioTM DD Stent on Inhibition of Neointimal Proliferation in Porcine Coronary Stent Restenosis Model
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Kim W, Jeong MH, Cha KS, Lee SH, Lim JH, Kim HG, Park HW, Hong YJ, Park OY, Kim JH, Ahn YK, Park JT, Kim MH, Cho JG, Park JC, Kang JC
- KMID: 2145613
- Korean Circ J.
- 2003 Nov;33(11):1028-1035.
- doi: 10.4070/kcj.2003.33.11.1028
BACKGROUND AND OBJECTIVES: In a recent multicenter trial probucol was found to reduce stent restenosis by improving the lumen dimension. The probucol was administered for 2 weeks before, and 4... -
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- The Effects of Probucol Combined with Antiplatelets on the Coronary Stented Patients
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Kim NH, Jeong MH, Kim W, Kim YR, Lee SU, Kim KH, Cho JH, Park JC, Na KJ, Ahn YK, Cho JG, Ahn BH, Park JC, Kang JC
- KMID: 2227312
- Korean Circ J.
- 2000 Jul;30(7):811-818.
- doi: 10.4070/kcj.2000.30.7.811
BACKGROUND: An antioxidant, probucol, prevents endothelial dysfunction and low density lipoprotein oxidation and also inhibits the secretion of interleukin-1 by macrophages. These effects of probucol may result in decreased production... -
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- The clinical effects of probucol combined with multivitamins and Tranilast on restenosis after percutaneous coronary intervention
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Bang DW, On YK, Kim DH, Suh J, Hyon MS, Kim SK, Kwon YJ
- KMID: 1927361
- Korean J Med.
- 2004 Nov;67(5):488-497.
BACKGROUND: Tranilast is an anti-allergic drug that suppresses the release of cytokines. An antioxidant, probucol, prevents endothelial dysfunction and oxidation of low density lipoprotein and also inhibits the secretion of... -
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- Effect of Probucol on the Apoptosis of Pancreatic Islet Cells in Multiple Low Dose Streptozotocin Induced Diabetic (LDSD) Mice
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Choi KM, Kim DR, Kim NH, Kim CH, Baik SH, Choi DS
- KMID: 2331743
- J Korean Diabetes Assoc.
- 2001 Apr;25(2):152-163.
BACKGROUND: Type 1 Diabetes Mellitus(DM) is consequence of pancreatic beta cell destruction by immune interactions of auto-reactive T cells and cytokines. In individuals with genetic predisposition, an environmental insult... -
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- Morphological Study of Effects of Oxidized Low Density Lipoprotein on Three Dimensionally Constructed Vascular Wall
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Park HC, Kim HC, Joo HZ, Park JK, Lee SJ
- KMID: 1941197
- J Korean Soc Vasc Surg.
- 2000 Nov;16(2):185-194.
PURPOSE: The purpose of this experiment was to study the effects of Ox-LDL (oxidized low density lipoprotein) and Ox-VLDL (oxidized very low density lipoprotein) with or without probucol treatment on... -
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- The change of serum level of total antioxidant status and cytokine, and in-stent restenosis after supplementation of antioxidant
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Yoon HG, Bang DW, Park SH, Ahn JH, Seo J, Yoon YJ, Hyon MS, Kim SK, Kwon YJ
- KMID: 2256619
- Korean J Med.
- 2006 Aug;71(2):158-165.
BACKGROUND: Oxidative stress might be a role in atherosclerosis and increased intake of antioxidant appear to be protective and modify neointimal formation. An antioxidant and probucol prevents endothelial dysfunction and... -
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- Effects of Angiotensin II on Glomerular Epithelial Cells Permeability Model; Role of Oxidative Stress
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Song CJ, Ha TS, Lee HS, Yoon OJ
- KMID: 2079396
- Korean J Nephrol.
- 2004 May;23(3):396-404.
BACKGROUND: Glomerular injury induced by angiotensin II (Ang II) may arise from its hemodynamic or non-hemodynamic actions including oxidative stress, or from such effects of Ang II acting in concert.... -
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- The effects of antiproliferative drugs at stenotic area associated with primary atherosclerotic lesions in apoE knockout mouse - Change of vascular remodeling
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Seo HS, Lee EM, Ahn JC, Kim SM, Hwang IH, Hwang KS, Song WH, Lim DS, Park CG, Kim YH, Shim WJ, Oh DJ, Ro YM
- KMID: 2227380
- Korean Circ J.
- 2000 Apr;30(4):517-527.
- doi: 10.4070/kcj.2000.30.4.517
Apolipoprotein (apo) E deficient mouse can produce reproducible fixed stenotic primary atherosclerotic lesion, which reveals failure to remodel of vascular lumen, in the ascending aorta, external carotid, common carotid, iliac,... -
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- Effects of Advanced Glycation Endproducts (AGE) on Rat Glomerular Epithelial Cells (GEC): Roles of Reactive Oxygen Species (ROS)
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Ha TS, Kim HS
- KMID: 1610148
- Korean J Nephrol.
- 2003 May;22(3):285-293.
BACKGROUND: AGE-induced oxidative stress is implicated in the development and progression of diabetic nephropathy. AGE also affect the GEC to increase their permeability, therefore, we investigate the possibility that AGE... -
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- Development of Novel Drug-Eluting Stents for Acute Myocardial Infarction
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Sim DS, Jeong MH
- KMID: 2390432
- Chonnam Med J.
- 2017 Sep;53(3):187-195.
- doi: 10.4068/cmj.2017.53.3.187
Delayed arterial healing at culprit sites after drug-eluting stent (DES) placement for acute myocardial infarction (AMI) is associated with increased risk of late stent thrombosis. The Korea Acute Myocardial Infarction... -
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- Inhibitory Effects of Siryungtang and Onbitang on Oxidation of Low Density Lipoprotein
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Lee JJ, Lee TW, Chang HH, Kim HJ, Ihm CG, Kim MJ
- KMID: 1989759
- Korean J Nephrol.
- 2001 May;20(3):478-485.
BACKGROUND: LDL deposition and local oxidation play a key role in the pathogenesis of atherosclerosis and glomerulosclerosis. Oxidation of LDL need to be catalyzed by copper or iron, whereas the... -
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- Puromycin aminonucleoside modulates p130Cas of podocytes
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Ha TS, Choi JY, Park HY
- KMID: 2140712
- Korean J Pediatr.
- 2012 Oct;55(10):371-376.
- doi: 10.3345/kjp.2012.55.10.371
PURPOSE: Puromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers... -
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