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Genetic etiologies of central precocious puberty

Lee HS

Pubertal onset is a complex process, which is influenced by genetic and environmental factors, such as obesity and endocrine-disrupting chemicals. In addition, the timing of normal puberty varies between individuals...
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Monogenic diabetes mellitus and clinical implications of genetic diagnosis

Kang E, Chung LY, Kim YJ, Oh KE, Rhie YJ

Monogenic diabetes mellitus, which is diabetes caused by a defect in a single gene that is associated with β cell function or insulin action, accounts for 1% to 6% of...
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Congenital hypogonadotropic hypogonadism: from clinical characteristics to genetic aspects

Kwon A, Kim HS

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by a deficiency in gonadotropin-releasing hormone (GnRH). CHH is characterized by delayed puberty and/or infertility; this is because GnRH is the...
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Do we need more genetic counselling in pediatric endocrine diseases?

Rhee EJ

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The association between alcohol use and suicide attempt in employees

Choo WY, Lee U, Park JH, Shin YC, Sim M, Oh KS, Shin DW, Jeon SW, Kim MK, Cho SJ

Purpose: This study aimed to analyze the alcohol use patterns that may influence suicide attempt in employees who have suicidal ideation. Methods: The 15,199 participants were classified into three groups according...
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Two cases of non-fluent variant primary progressive aphasia with different pathological diagnoses

Hwangbo S, Hwang S, Suh MK, Kim SJ, Kim Y, Kim HJ, Na DL, Seo SW, Suh YL

Non-fluent variant primary progressive aphasia (nfvPPA), a subtype of frontotemporal lobar dementia syndrome, has been proven to have various pathological diagnoses. A 63-year-old woman and 71-year-old man separately visited our...
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Is transrectal ultrasound-guided systematic biopsy necessary after PI-RADS 4 is targeted?

Kim HS, Park BK

Purpose: Target biopsy is usually performed in Prostate Imaging Reporting and Data System (PI-RADS) 4. Still, it is unclear if adding systematic biopsy to target biopsy influences cancer detection. The...
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