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Membrane stretch increases the activity of Ca(2+)-activated K+ channels in rabbit coronary vascular smooth muscles

Lee CJ, Kwon S, Lee YH, Ahn DS, Kang BS

It has been proposed that Ca(2+)-activated K+ channels play an essential role in maintaining vascular tone during stretch of blood vessel. However, the underlying mechanism of stretch-induced change of Ca(2+)-activated...
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Reduced dihydroxyacetone sensitivity and normal sensitivity to glyceraldehyde and oxidizing agent of ATP-sensitive K+ channels of pancreatic beta cells in NIDDM rats

Song DK, Park WK, Bae JH, Park MK, Kim SJ, Ho WK, Earm YE

The inhibition of ATP-sensitive K+(KATP) channels in pancreatic beta cells is a key step of insulin secretion induced by glucose. Glucose-induced insulin secretion from the beta cells is selectively...
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Sulfhydryl modification affects coronary artery tension by changing activity of delayed rectifier K+ current

Ha M, Kwon S, Lee YH, Yeon D, Ahn DS

It has been reported that a change in the cellular redox state may be involved in the regulation of vascular tone, but the underlying mechanism is not fully understood. The...
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Ionic Mechanisms of Desflurane on Prolongation of Action Potential Duration in Rat Ventricular Myocytes

Chae JE, Kim HS, Ahn DS, Park WK

PURPOSE: Despite the fact that desflurane prolongs the QTC interval in humans, little is known about the mechanisms that underlie these actions. We investigated the effects of desflurane on action...
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Effects of vanadate on vascular contractility and membrane potential in the rabbit aorta

Chung SM, Ahn DS, Seok HS, Jeong Y, Kang BS

Isolated rabbit aortic ring with intact endothelial cell preparations precontracted with NE (10(-7) M) were relaxed by vanadate in a dose dependent manner (from 0.2 to 2 mM). Application of...
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The involvement of K+ channels and the possible pathway of EDHF in the rabbit femoral artery

Kwon SC, Pyun WB, Park GY, Choi HK, Paik KS, Kang BS

Experiments were designed to characterize the cellular mechanisms of action of endothelium-derived vasodilator substances in the rabbit femoral artery. Acetylcholine (ACh, 10(-8)-10(-5) M) induced a concentration-dependent relaxation...
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Effect of hypocapnia on extracellular glutamate and glycine concentrations during peri-ischemic period in the rabbit hippocampus

Choi KT, Chung JK, Kwak CS, Kim HK

Glutamate (GLU) is a neurotransmitter. Massive release of GLU and glycine (GLY) into the brain's extracellular space may be triggered by ischemia, and may result in acute neuronal lysis or...
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Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms

Xi S, Zhou G, Zhang X, Zhang W, Cai L, Zhao C

Total aralosides of Aralia elata (Miq) Seem (TASAES) from Chinese traditional herb Longya Aralia chinensis L was found to improve cardiac function. The present study was to determine the protective...
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