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Actions of potassium channel openers in rat detrusor urinae

Kim SJ, Kim NS, Lee JL

This study was performed to investigate the action of potassium channel openers on the mechanical activity of detrusor muscle isolated from rats. Detrusor muscle strips, 15 mm in length, were...
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Effects of Tamoxifen on the Voltage-dependent Ionic Currents in Mouse Colonic Smooth Muscle Cells

Lee DM, Chang SJ, Park CG, Kim MW, Lim GH, Choi S, Yeum CH, Yoon PJ, Jun JY

  • KMID: 772862
  • Korean J Gastroenterol.
  • 2005 Nov;46(5):388-395.
BACKGROUND/AIMS: Tamoxifen is a widely used anticancer drug for breast cancer with frequent gastrointestinal side effects. Changes in gastrointestinal motility is associated with altered activities of membrane ion channels....
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Fatty acids directly increase the activity of Ca(2+)-activated K+ channels in rabbit coronary smooth muscle cells

Ahn DS, Kim YB, Lee YH, Kang BS, Kang DH

The large conductance Ca2+ activated K+ channel (BK channel) has been considered to play an important role in the excitability and contractility of vascular smooth muscle cells. Activation of the...
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Activation of Ca(2+)-activated K+ channels by beta agonist in rabbit coronary smooth muscle cells

Ahn DS, Jeong YK, Lee YH, Kang BS

Isoproterenol (ISO), a beta agonist, causes hyperpolarization of coronary smooth muscle cells via an increase in K+ conductance. This hyperpolarization may cause the coronary vasorelaxation by decreasing the cytoplasmic Ca2+...
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The effects of cromakalim on the mediator releases from guinea pig lung mast cell activated by specific antigen-antibody reactions

Ro JY, Yim YN, Kim KH

The inhibitory effect of cromakalim on the mediator release from mast cells caused by antigenantibody reactions was in controversy with the specific antigen used. However, it has recently been observed...
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