- p53 codon 72 polymorphism and risk of cervical carcinoma in Korean women
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Baek WK, Cho JW, Suh SI, Suh MH, Shin DH, Cho CH, Lee TS, Cha SD
- KMID: 1731236
- J Korean Med Sci.
- 2000 Feb;15(1):65-67.
- doi: 10.3346/jkms.2000.15.1.65
A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro). A recent... -
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- Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients
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Hong YS, Chang JH, Kwon OJ, Ham YA, Choi JH
- KMID: 755008
- Exp Mol Med.
- 1998 Dec;30(4):192-198.
The levels of expressions and catalytic activities of cytochrome P450 (CYP1A1) and glutathione-S-transferase class mu (GSTM1) enzymes in lungs and their metabolic balance may be an important determinant host factor underlying lung cancer.... -
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- Association of the ACE gene polymorphism with the progression of autosomal dominant polycystic kidney disease
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Lee KB, Kim UK, Lee CC
- KMID: 1730640
- J Korean Med Sci.
- 2000 Aug;15(4):431-435.
- doi: 10.3346/jkms.2000.15.4.431
Renin-angiotensin system is considered important in the genesis of hypertension and development of end-stage renal disease (ESRD) in autosomal dominant polycystic kidney disease (ADPKD). The angiotensin converting enzyme (ACE) gene... -
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- The Roles of Stromelysin-1 and the Gelatinase B Gene Polymorphism in Stable Angina
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Kim JS, Park HY, Kwon JH, Im EK, Choi D, Jang Y, Cho SY
- KMID: 1122006
- Yonsei Med J.
- 2002 Aug;43(4):473-481.
- doi: 10.3349/ymj.2002.43.4.473
Matrix metalloproteinases contribute to vascular remodeling by breaking down extracellular-matrix while new matrix is synthesized. Of the variety of MMPs, stromelysin-1 and gelatinase B may have key roles in coronary... -
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- A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter-160 is Not Associated with Risk of Korean Gastric Cancer
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Park WS, Cho YG, Park JY, Kim CJ, Lee JH, Kim HS, Lee JW, Song YH, Park CH, Park YK, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY
- KMID: 648900
- J Korean Med Sci.
- 2003 Aug;18(4):501-504.
- doi: 10.3346/jkms.2003.18.4.501
Recently, the -160 C/A polymorphism, located within the regulatory region of E-cadherin promoter, has been shown to influence E-cadherin transcription by altering transcription factor binding. We examined the effect of... -
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- Apolipoprotein E polymorphism in non-diabetic patients with acute coronary syndrome
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Kim IJ, Hong BK, Lee BK, Kwon HM, Kim D, Choi EY, Byun KH, Kim JH, Song KS, Kim HS
- KMID: 711665
- Yonsei Med J.
- 1999 Aug;40(4):377-382.
- doi: 10.3349/ymj.1999.40.4.377
Since a decade ago, apolipoprotein (apo) E polymorphism has been focussed as a risk factor for cardiovascular disease. ApoE plays a central role as a receptor ligand for... -
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- The angiotensin converting enzyme genetic polymorphism in acute coronary syndrome--ACE polymorphism as a risk factor of acute coronary syndrome
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Park HY, Kwon HM, Kim D, Jang Y, Shim WH, Cho SY, Kim HS
- KMID: 1081029
- J Korean Med Sci.
- 1997 Oct;12(5):391-397.
- doi: 10.3346/jkms.1997.12.5.391
The deletion polymorphism of angiotensin converting enzyme (ACE) genotype has been reported as an independent risk factor for the development of myocardial infarction (MI). However there are conflicting data... -
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- Lack of Relationship between Vitamin D Receptor Polymorphism and Bone Erosion in Rheumatoid Arthritis
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Lee CK, Hong JS, Cho YS, Yoo B, Kim GS, Moon HB
- KMID: 648255
- J Korean Med Sci.
- 2001 Apr;16(2):188-192.
- doi: 10.3346/jkms.2001.16.2.188
We performed this study to investigate the possible association between vitamin D receptor (VDR) gene polymorphism and the focal bone erosion in rheumatoid arthritis (RA) patients in Korea. One hundred... -
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- Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Type 1 Gene Polymorphism in Patients with Gastric Ulcer Complicated with Bleeding
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Kim HS, Hwang KY, Chung IK, Park SH, Lee MH, Kim SJ, Hong SY
- KMID: 1099794
- J Korean Med Sci.
- 2003 Feb;18(1):58-64.
- doi: 10.3346/jkms.2003.18.1.58
Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) may be involved in the pathogenesis of peptic ulcers through suppression of fibrinolysis. This study was designed to investigate... -
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- Point mutation and polymorphism in Duchenne/Becker muscular dystrophy (D/BMD) patients
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Chaturvedi LS, Mukherjee , Srivastava S, Mittal RD, Mittal B
- KMID: 1457538
- Exp Mol Med.
- 2001 Dec;33(4):251-256.
Duchenne and Becker muscular dystrophies (D/BMD) are caused by mutations in the dystrophin gene. Two-thirds of patients have large intragenic deletions or duplications and the remaining one-third have point mutations,... -
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- Angiotensin converting enzyme gene polym orphism in Korean patients with primary knee osteoarthritis
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Hong SJ, Yang HI, Yoo MC, In CS, Yim SV, Jin SY, Choe BK, Chung JH
- KMID: 1094700
- Exp Mol Med.
- 2003 Jun;35(3):189-195.
Angiotensin converting enzyme (ACE) plays an important role in the physiology of vasculature, blood pressure and inflammation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has been widely investigated in... -
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- GSTP1 Polymorphism, Cigarette Smoking and Cervical Cancer Risk in Korean Women
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Jee SH, Lee JE, Kim S, Kim JH, Um SJ, Lee SJ, Namkoong S, Park JS
- KMID: 1093945
- Yonsei Med J.
- 2002 Dec;43(6):712-716.
- doi: 10.3349/ymj.2002.43.6.712
Previous studies have suggested that glutathione S-transferase (GST) genotypes may play a role in determining susceptibility to cervical cancer, though the data have often been conflicting. The objective of this... -
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- Analysis of polymorphic region of GAM-1 gene in Plasmodium vivax Korean isolates
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Kho WG, Chung JY, Hwang UW, Chun JH, Park YH, Chung WC
- KMID: 1720402
- Korean J Parasitol.
- 2001 Dec;39(4):313-318.
- doi: 10.3347/kjp.2001.39.4.313
The identification, characterization and quantification of Plasmodium sp. genetic polymorphism are becoming increasingly important in the vaccine development. We investigated polymorphism of Plasmodium vivax GAM-1 (PvGAM-1) gene in 30 Korean... -
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- NRAMP1 gene polymorphisms in patients with rheumatoid arthritis in Koreans
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Yang YS, Kim SJ, Kim JW, Koh EM
- KMID: 1731240
- J Korean Med Sci.
- 2000 Feb;15(1):83-87.
- doi: 10.3346/jkms.2000.15.1.83
Natural resistance-associated macrophage protein 1 (Nramp1) is a genetic locus associated with innate resistance or susceptibility of murine hosts to infection with intracellular pathogens such as Salmonella, Leishmania and Mycobacterium.... -
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- Tumor Necrosis Factor-alpha Levels and Promoter Polymorphism in Patients with Kawasaki Disease in Korea
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Ahn SY, Jang GC, Shin JS, Shin KM, Kim DS
- KMID: 1091043
- Yonsei Med J.
- 2003 Dec;44(6):1021-1026.
- doi: 10.3349/ymj.2003.44.6.1021
Tumor necrosis factor (TNF) -alpha plays a major role in the pathogenesis of Kawasaki disease (KD), a systemic vasculitis primarily affecting young children. We performed this study to examine the... -
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- Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia
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Choi H, Kang JY, Yoon HS, Han SS, Whang CS, Moon IG, Shin HH, Park JB
- KMID: 1733485
- J Korean Med Sci.
- 2004 Apr;19(2):253-257.
- doi: 10.3346/jkms.2004.19.2.253
We tested the hypothesis that angiotensin-converting enzyme (ACE) and angiotensinogen gene polymorphism influence the incidence, development and outcome of preeclampsia. Subjects were recruited from 90 Korean patients with preeclampsia during... -
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- Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
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Seo JC, Han SW, Yin CS, Koh HK, Kim CH, Kim EH, Leem KH, Lee HS, Park HJ, Kim SA, Choe BK, Lee HJ, Yim SV, Kim CJ, Chung JH
- KMID: 931880
- Exp Mol Med.
- 2002 Sep;34(4):294-298.
Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. Apo-1/Fas gene is one of the mediators of apoptosis in stroke. MvaI polymorphism... -
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- Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age
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Song KS, Song JW, Choi JR, Kim HK, Shin JS, Kim JH
- KMID: 1085748
- Exp Mol Med.
- 2001 Jun;33(2):106-109.
Hyperhomocysteinemia is known to be associated with an increased risk of myocardial infarction, stroke, peripheral arterial disease, and venous thrombosis. Gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS)... -
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- Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease
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Lee DM, Lee SO, Mun BS, Ahn HS, Park HY, Lee HS, Kim DG
- KMID: 863110
- Korean J Hepatol.
- 2002 Dec;8(4):355-362.
BACKGROUND/AIMS: Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three... -
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- Effects of Val34Leu and Val35Leu polymorphism on the enzyme activity of the coagulation factor XIII-A
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Lee IH, Chung SI, Lee SY
- KMID: 755212
- Exp Mol Med.
- 2002 Nov;34(5):385-390.
Change in fibrin stabilizing activity of factor XIII A subunit (FXIII-A) caused by a specific mutation, Val34Leu, is recently implicated to incidences of pathophysiology of thrombosis. In an effort to... -
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