- Regulation and Role of EZH2 in Cancer
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Yamaguchi , Hung MC
- KMID: 2167686
- Cancer Res Treat.
- 2014 Jul;46(3):209-222.
Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription. Enhancer of zeste homolog 2 (EZH2) is an... -
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- Long Non-coding RNA HOTAIR Expression in Diffuse Large B-Cell Lymphoma: In Relation to Polycomb Repressive Complex Pathway Proteins and H3K27 Trimethylation
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Oh EJ, Kim SH, Yang WI, Ko YH, Yoon SO
- KMID: 2353599
- J Pathol Transl Med.
- 2016 Sep;50(5):369-376.
- doi: 10.4132/jptm.2016.06.06
BACKGROUND: A long non-coding RNA hox transcript antisense intergenic RNA (HOTAIR) is involved in epigenetic regulation through chromatin remodeling by recruiting polycomb repressive complex 2 (PRC2) proteins (EZH2, SUZ12, and... -
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- High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer
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Jang SH, Lee JE, Oh MH, Lee JH, Cho HD, Kim KJ, Kim SY, Han SW, Kim HJ, Bae SB, Lee HJ
- KMID: 2176321
- J Breast Cancer.
- 2016 Mar;19(1):53-60.
- doi: 10.4048/jbc.2016.19.1.53
PURPOSE: The enhancer of zeste homologue 2 (EZH2) is a catalytic subunit of the polycomb repressive complex 2, a highly conserved histone methyltransferase. EZH2 overexpression has been implicated in various... -
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