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Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts

Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH

Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue...
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TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling

Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M

PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple...
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