- Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
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Jiang S, Uddin MJ, Yu X, Piao L, Dorotea D, Oh GT, Ha H
- KMID: 2536142
- Diabetes Metab J.
- 2022 Nov;46(6):829-842.
- doi: 10.4093/dmj.2021.0274
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism... -
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- Prognostic Role of Serum Levels of Uric Acid in Amyotrophic Lateral Sclerosis
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Oh SI, Baek S, Park JS, Piao L, Oh KW, Kim SH
- KMID: 2179758
- J Clin Neurol.
- 2015 Oct;11(4):376-382.
- doi: 10.3988/jcn.2015.11.4.376
BACKGROUND AND PURPOSE: It has been suggested that oxidative stress is one of the pathomechanisms underlying amyotrophic lateral sclerosis (ALS), and thus antioxidants such as uric acid (UA) that could... -
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- Effects of Amisulpride Administration on Body Weight and Metabolic Abnormalities in Mice
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Lee HJ, Shin YO, Jeon BW, Piao L, Kim JL
- KMID: 1481601
- Korean J Biol Psychiatry.
- 2008 May;15(2):101-109.
OBJECTIVES: This study was conducted to examine the effects on food intake, body weight, and metabolic parameters by amisulpride administration in male and female mice, comparing the effects of risperidone... -
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- Endogenous catalase delays high-fat diet-induced liver injury in mice
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Piao L, Choi J, Kwon G, Ha H
- KMID: 2376960
- Korean J Physiol Pharmacol.
- 2017 May;21(3):317-325.
- doi: 10.4196/kjpp.2017.21.3.317
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of... -
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- Integrative Omics Reveals Metabolic and Transcriptomic Alteration of Nonalcoholic Fatty Liver Disease in Catalase Knockout Mice
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Na J, Choi SA, Khan A, Huh JY, Piao L, Hwang I, Ha H, Park YH
- KMID: 2442004
- Biomol Ther.
- 2019 Feb;27(2):134-144.
- doi: 10.4062/biomolther.2018.175
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the incidence of obesity; however, the underlying mechanisms are unknown. In this study, high-resolution metabolomics (HRM) along with transcriptomics... -
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- Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
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Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, Hong JH, Piao L, Park J, Kim JM, Kweon GR, Kang SH, Han J, Hur GM
- KMID: 1052941
- Exp Mol Med.
- 2008 Apr;40(2):186-195.
- doi: 10.3858/emm.2008.40.2.186
Previous studies have demonstrated that rottlerin, a specific PKCdelta inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-dependent or -independent pathway. However, its ability to regulate necrotic cell death,... -
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