- Inhibition of PTK Pa t hway by Genistein in Diabetic Rat
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Kim HC
- KMID: 2108788
- J Korean Ophthalmol Soc.
- 1999 Aug;40(8):2181-2189.
The objective of this study is to determine if the elevated retinal levels of phosphotyrosine in the Zucker diabetic fatty rats can be reduced by systemic administration of genistein,a protein... -
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- Activation of Protein Tyrosine Kinase Pathway in Diabetic Rats
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Kim HC
- KMID: 2336673
- J Korean Ophthalmol Soc.
- 1998 May;39(5):939-948.
One mechanism of vascular damage in diabetic retinopathy is thought to result from the effect of hyperglycemia on the neural retina and microvasculature eventually causing the signs of capillary closure... -
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- Association of Killer Cell Ig-like Receptor (KIR) with an Adaptor Protein Shc
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Cho HI, Chwae YJ, Park SM, Kim J
- KMID: 2150616
- Immune Netw.
- 2006 Jun;6(2):67-75.
- doi: 10.4110/in.2006.6.2.67
BACKGROUND: Cytotoxic function of killer cells is inhibited by specific recognition of class I MHC molecules on target cells by inhibitory killer Ig-like receptors (KIR) expressed on NK cells and... -
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- Somatostatin Receptors in Lung Cancer: From Function to Molecular Imaging and Therapeutics
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Callison J, Walker RC, Massion PP
- KMID: 2005737
- J Lung Cancer.
- 2011 Dec;10(2):69-76.
- doi: 10.6058/jlc.2011.10.2.69
Lung cancer is a deadly disease that is difficult to diagnose and even more difficult to treat effectively. Many pathways are known to affect tumor growth, and targeting these pathways... -
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- Preferential Cytotoxic Effect of Genistein on G361 Melanoma Cells Via Inhibition of the Expression of Focal Adhesion Kinase
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Park SR, Kwak HH, Park BS, Kim GC
- KMID: 1431133
- Int J Oral Biol.
- 2012 Dec;37(4):189-195.
Resistance to the induction of apoptosis is a possible mechanism by which tumor cells can survive anti-neoplastic treatments. Melanoma is notoriously resistant to anti-neoplastic therapy. Previous studies have demonstrated focal... -
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- The Mechanisms of Antitumor Effect of Anti-p185HER2/neu Monoclonal Antibody and Peptide Mimetic
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Park BW, Kim KS, Kim SI, Lee KS
- KMID: 2209280
- J Korean Surg Soc.
- 2000 Jun;58(6):745-751.
PURPOSE: Anti-p185HER2/neu monoclonal antibody (mAb) that can induce phenotypic reversion and monoclonal antibodies specific for the p185HER2/neu growth factor receptor that are able to diminish its kinase-signaling properties represent a... -
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- The Effect of Hydrogen Peroxide on the Migration and FAK Activation in Lens Epithelial Cells
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Park YM, Kim JA, Ahn BT, Wee WR, Lee JH, Lee YC, Kim HS, Joo CK
- KMID: 2109218
- J Korean Ophthalmol Soc.
- 2001 Sep;42(9):1336-1343.
PURPOSE: Hydrogen peroxide has been implicated as a causative factor of various cellular dysfunction, cell death, transformation. In addition, oxidative stress has been suggested as a crucial inducer of cataract... -
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- CD99 activates T cells via a costimulatory function that promotes raft association of TCR complex and tyrosine phosphorylation of TCR zeta
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Oh KI, Kim BK, Ban YL, Choi EY, Jung KC, Lee IS, Park SH
- KMID: 1094658
- Exp Mol Med.
- 2007 Apr;39(2):176-184.
We investigated the co-stimulatory role of a cell-surface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or... -
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- A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation
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Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS
- KMID: 946654
- Exp Mol Med.
- 2010 Mar;42(3):216-222.
- doi: 10.3858/emm.2010.42.3.023
Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,... -
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- Nonspecific association of 2',3'-cyclic nucleotide 3'-phosphodiesterase with the rat forebrain postsynaptic density fraction
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Cho SJ, Jung JS, Shin SC, Jin IN, Ko BH, Kim Kwon Y, Suh-Kim H, Moon IS
- KMID: 1119329
- Exp Mol Med.
- 2003 Dec;35(6):486-493.
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a protein of unknown function in vivo, is abundantly expressed in myelinating glia in two isoforms, CNP1 and CNP2. In this study, immunoblot analysis showed... -
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- Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
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Lee KM
- KMID: 1115949
- Exp Mol Med.
- 2006 Dec;38(6):703-717.
Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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