- Emodin prevents intima thickness via Wnt4/Dvl-1/beta-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats
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Hua JY, He YZ, Xu Y, Jiang XH, Ye W, Pan ZM
- KMID: 2155424
- Exp Mol Med.
- 2015 Jun;47(6):e170.
- doi: 10.1038/emm.2015.36
Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities,... -
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- O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes
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Park SY, Ryu J, Lee W
- KMID: 1056235
- Exp Mol Med.
- 2005 Jun;37(3):220-229.
It has been known that O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins plays an important role in transcription, translation, nuclear transport and signal transduction. The increased flux of glucose through the... -
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- Ginseng Total Saponin Improves Podocyte Hyperpermeability Induced by High Glucose and Advanced Glycosylation Endproducts
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Ha TS, Choi JY, Park HY, Lee JS
- KMID: 1785989
- J Korean Med Sci.
- 2011 Oct;26(10):1316-1321.
- doi: 10.3346/jkms.2011.26.10.1316
Early diabetic nephropathy is characterized by glomerular hyperpermeability as a result of impaired glomerular filtration structure caused by hyperglycemia, glycated proteins or irreversible advanced glycosylation endproducts (AGE). To investigate the... -
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- Impact of Cyclosporin on Podocyte ZO-1 Expression in Puromycin Aminonucleoside Nephrosis Rats
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Kim BS, Park HC, Kang SW, Choi KH, Ha SK, Han DS, Lee HY
- KMID: 2158124
- Yonsei Med J.
- 2005 Feb;46(1):141-148.
- doi: 10.3349/ymj.2005.46.1.141
Puromycin aminonucleoside (PAN) -induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, but the mechanism of PAN's effect is not completely understood. To investigate whether proteinuria in the... -
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