- Blockade of P-Glycoprotein Decreased the Disposition of Phenformin and Increased Plasma Lactate Level
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Choi MK, Song IS
- KMID: 2170533
- Biomol Ther.
- 2016 Mar;24(2):199-205.
- doi: 10.4062/biomolther.2015.087
This study aimed to investigate the in vivo relevance of P-glycoprotein (P-gp) in the pharmacokinetics and adverse effect of phenformin. To investigate the involvement of P-gp in the transport of... -
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- Aldehyde dehydrogenase is used by cancer cells for energy metabolism
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Kang JH, Lee SH, Hong D, Lee JS, Ahn HS, Ahn JH, Seong TW, Lee CH, Jang H, Hong KM, Lee C, Lee JH, Kim SY
- KMID: 2362296
- Exp Mol Med.
- 2016 Nov;48(11):e272.
- doi: 10.1038/emm.2016.103
We found that non-small-cell lung cancer (NSCLC) cells express high levels of multiple aldehyde dehydrogenase (ALDH) isoforms via an informatics analysis of metabolic enzymes in NSCLC and immunohistochemical staining of... -
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