- Role of Regulatory Cells in Oral Tolerance
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Wawrzyniak M, O'Mahony L, Akdis M
- KMID: 2413384
- Allergy Asthma Immunol Res.
- 2017 Mar;9(2):107-115.
- doi: 10.4168/aair.2017.9.2.107
The immune system is continuously exposed to great amounts of different antigens from both food and intestinal microbes. Immune tolerance to these antigens is very important for intestinal and systemic... -
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- Autoimmunity
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Kim JG
- KMID: 2279445
- Korean J Pediatr.
- 2007 Dec;50(12):1165-1172.
- doi: 10.3345/kjp.2007.50.12.1165
Self/non-self discrimination and unresponsiveness to self is the fundamental properties of the immune system. Self-tolerance is a state in which the individual is incapable of developing an immune response to... -
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- Peripheral Generation of CD4+ CD25+ Foxp3+ Regulatory T Cells
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Kim BS, Park YJ, Kang CY
- KMID: 2150621
- Immune Netw.
- 2007 Mar;7(1):1-9.
- doi: 10.4110/in.2007.7.1.1
CD4+ CD25+ regulatory T cells (Tregs) expressing the lineage-specific marker Foxp3 represent an important regulatory T cell that is essential for maintaining peripheral tolerance. Although it was believed that Treg... -
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- Regulatory T Cells in the Human Immune System
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Kim YM
- KMID: 2277168
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2010 Dec;53(12):737-748.
- doi: 10.3342/kjorl-hns.2010.53.12.737
Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting... -
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- Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy
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Song J
- KMID: 2355021
- Immune Netw.
- 2016 Oct;16(5):281-285.
- doi: 10.4110/in.2016.16.5.281
CD4⺠regulatory T cells (Tregs) are essential for normal immune surveillance, and their dysfunction can lead to the development of autoimmune diseases, such as type-1 diabetes (T1D). T1D is a... -
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- Emerging Roles of Lymphatic Vasculature in Immunity
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Kim KW, Song JH
- KMID: 2368978
- Immune Netw.
- 2017 Feb;17(1):68-76.
- doi: 10.4110/in.2017.17.1.68
The lymphatic vasculature has been regarded as a passive conduit for interstitial fluid and responsible for the absorption of macromolecules such as proteins or lipids and transport of nutrients from... -
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- Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
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Park HJ, Kim DH, Choi JM
- KMID: 2168215
- Hanyang Med Rev.
- 2013 Feb;33(1):10-16.
- doi: 10.7599/hmr.2013.33.1.10
Follicular helper T cells (Tfh) play a significant role in providing T cell help to B cells during the germinal center reaction, where somatic hypermutation, affinity maturation, isotype class switching,... -
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- Suppression of Pathogenic Autoreactive CD4+ T Cells by CD137-mediated Expansion of CD4+CD25+ Regulatory T Cells in Graves' Disease
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Kim ES, Jung HW, Choi JI, Nam-Goong , Hong SH, Kim YI
- KMID: 1523102
- J Korean Endocr Soc.
- 2007 Oct;22(5):332-338.
- doi: 10.3803/jkes.2007.22.5.332
BACKGROUND: Graves' disease (GD) is an organ-specific autoimmune disease that is characterized by lymphocyte infiltration of the thyroid, which finally leads to follicular destruction. The CD4+CD25+ regulatory T cells are... -
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- Novel Pharmacologic Therapies in the Treatment of Systemic Lupus Erythematosus
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Shim SC
- KMID: 2168201
- Hanyang Med Rev.
- 2012 May;32(2):83-93.
- doi: 10.7599/hmr.2012.32.2.83
Systemic lupus erythematosus (lupus) is an autoimmune disease that affects primarily women, especially those of reproductive age. Lupus is a prototypic organ non-specific autoimmune disease that may affect any organ... -
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- Immunomodulatory Function of Mesenchymal Stem Cells for Rheumatoid Arthritis
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Kang MI, Park YB
- KMID: 2356482
- J Rheum Dis.
- 2016 Oct;23(5):279-287.
- doi: 10.4078/jrd.2016.23.5.279
Developments in our comprehension of the autoimmune and inflammation mechanisms in rheumatoid arthritis (RA) have produced targeted therapies that block aberrant immune cells and cytokine networks, and improved treatment of... -
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- Deficiency of Foxp3+ Regulatory T Cells Exacerbates Autoimmune Arthritis by Altering the Synovial Proportions of CD4+ T Cells and Dendritic Cells
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Jang E, Cho ML, Oh HJ, Youn J
- KMID: 2168002
- Immune Netw.
- 2011 Oct;11(5):299-306.
- doi: 10.4110/in.2011.11.5.299
BACKGROUND: CD4+Fop3+ regulatory T cells (Tregs) are needed to maintain peripheral tolerance, but their role in the development of autoimmune arthritis is still debated. The present study was undertaken to... -
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- The Role of MicroRNAs in Regulatory T Cells and in the Immune Response
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Ha TY
- KMID: 2150690
- Immune Netw.
- 2011 Feb;11(1):11-41.
- doi: 10.4110/in.2011.11.1.11
The discovery of microRNA (miRNA) is one of the major scientific breakthroughs in recent years and has revolutionized current cell biology and medical science. miRNAs are small (19~25nt) noncoding RNA... -
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- Alternation of Cytokine mRNA Expression in Human Blood Samples before and after Allogeneic Transfusions
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Beak HM, Nahm CH, Yoo SK, Choi JW, Pai SH, Mo JW, Park CS
- KMID: 1889903
- Korean J Lab Med.
- 2003 Aug;23(4):287-291.
BACKGROUND: Despite proposing clonal depletion, anergy, and alternation of cytokines in peripheral tolerance, the precise mechanism for the immunosuppressive effect of blood transfusion remains unknown. Here, we evaluated the effect... -
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