- The expression of P-glycoprotein and the DNA content as a prognostic indicator in breast cancers
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Bae JW, Whang CW
- KMID: 1693922
- J Korean Surg Soc.
- 1993 Sep;45(3):343-352.
No abstract available. -
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- Acute monocytic leukemia with P-glycoprotein expression
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Lee HK, Han KJ, Lee KY, Shim SI, Kim SW
- KMID: 1684915
- Korean J Clin Pathol.
- 1991 Aug;11(2):409-412.
No abstract available. -
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- Expression of p-glycoprotein on human bladder transitional cell carcinoma
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Jang SK, Lee JH, Son JW, Lee CH, Kim JI, Chae SY
- KMID: 1694316
- J Korean Cancer Assoc.
- 1993 Apr;25(2):268-275.
No abstract available. -
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- Overexpression of P-glycoprotein in gastric cancer by immunohistochemical staining method
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Chung HC, Lim HY, Koh EH, Kim JH, Roh JK, Min JS, Choi JJ, Youn JK, Kim BS, Lee KB
- KMID: 1694128
- J Korean Cancer Assoc.
- 1991 Sep;23(3):485-494.
No abstract available. -
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- Expression of DNA Topoisomerase II and P-Glycoprotein in Breast Cancer
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Park HR, Jung EH, Sohn JH, Park YE
- KMID: 2175461
- J Korean Cancer Assoc.
- 1997 Apr;29(2):242-249.
PURPOSE: To determine whether the expression of DNA topoisomerase II and P-glycoprotein are of prognostic value. MATERIALS AND METHODS: We evaluated the expression of DNA topoisomerase II and P-glycoprotein immunohistochemically... -
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- Expression of Multidrug Resistance Gene Product in Laryngeal Squamous Cell Carcinoma
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Chung SM
- KMID: 2052732
- Ewha Med J.
- 1996 Mar;19(1):125-131.
- doi: 10.12771/emj.1996.19.1.125
OBJECTIVES: Various mechanisms are involved in drug resistance of tumor cells. Among them one such mechanism is the overexpression of the multidrug resistance(mdr1) gene product P-glycoprotein(Pgp) that functions as an... -
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- Recent updates on extranodal NK/T-cell lymphoma
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Kim WS
- KMID: 2257146
- Korean J Med.
- 2009 Nov;77(5):565-570.
Extranodal NK/T-cell lymphoma (ENKL) is a rare subtype of NHL (Non-Hodgkin lymphoma]. It occurs mostly in the nasal and paranal areas. Most of the cases are presented stage I/II. International... -
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- Clinical Significance of Multidrug Resistance-1 Gene Over-expression in Childhood Acute Lymphoblastic Leukemia
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Oh SH
- KMID: 2072495
- Korean J Pediatr Hematol Oncol.
- 2001 Oct;8(2):206-214.
PURPOSE: The object of this study is to elucidate the clinical significance of multidrug resistance gene-1 (MDR-1) over-expression in childhood acute lymphoblastic leukemia. METHODS: 41 bone marrow specimen from... -
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- The Effect of Hyperthermia on p-Glycoprotein Expression, Glutathione Content and Glutathione-related Enzyme Activities in Human Renal Cell Carcinoma Cells
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Heo YC, Lee ES, Park WH
- KMID: 2060764
- Korean J Urol.
- 1999 Feb;40(2):168-174.
PURPOSE: Resistance to anticancer chemotherapeutic drug remains a major obstacle in cancer chemotherapy. Multidrug-resistance(MDR) gene overexpression and detoxification by glutathione are believed to be involved in adriamycin and cisplatin resistance.... -
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- Immunohistochemical Expression of P-Glycoprotein in Gynecologic Malignancies
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Noh HT, Sohn YS, Rhoo CS, Lee OS
- KMID: 1980032
- Korean J Gynecol Oncol Colposc.
- 1997 Mar;8(1):8-23.
The expression of P-glycoprotein in gynecological tissues was studied by immunohistochemical staining methods. Aspects of study included the expression of P-glycoprotein in different tissues throughout the clinical treatment regimen, the... -
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- The value of immunohistochemical detection of P-glycoprotein in breast cancer before and after induction chemotherapy
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Koh EH, Chung HC, Lee KB, Lim HY, Kim JH, Roh JK, Min JS, Lee KS, Kim BS
- KMID: 1964885
- Yonsei Med J.
- 1992 Jun;33(2):137-142.
- doi: 10.3349/ymj.1992.33.2.137
We have studied the patterns of P-glycoprotein expression before and after 3 cycles of induction chemotherapy (5-fluorouracil, adriamycin and cyclophosphamide) using immunohistochemically stained paraffin-embedded specimen of 28 patients with locally... -
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- Expression of Multidrug Resistance (MDR) Associated P-glycoprotein of Acute Lymphoblastic Leukemia in Children
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Choi YJ, U CU, Lee JH, Lee KC, Kim SK, Park SE
- KMID: 2072474
- Korean J Pediatr Hematol Oncol.
- 1999 Apr;6(1):39-47.
PURPOSE: To evaluate the association between multidrug resistance (MDR) gene and prognosis of acute lymphoblastic leukemia (ALL), several parameters were compared according to the expression status of MDR associated... -
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- Does 3-O-Methyldopa(3-OMD) Inhibit the Binding of Levodopa to Plasma Protein
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Bae JW, Harder S
- KMID: 1554205
- Korean J Psychopharmacol.
- 1999 Oct;10(2):180-184.
OBJECTIVE: We determined the influence of 3-OMD in the protein binding of levodopa to estimate the effect of 3-OMD on the penetration of levodopa into brain. METHOD: P-glycoprotein in the brain... -
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- Study on Correlation between the Expression of P-Glycoprotein and the Effect of Chemotherapy in Transitional Cell Carcinoma
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Ryu SB, Shin CS, Park CS, Min BK
- KMID: 1662188
- Korean J Urol.
- 1995 Apr;36(4):349-358.
The resistance of neoplastic cells to chemotherapeutic agents may develops by a variety mechanisms. One of these mechanisms seems to be the amplification or overexpression of the multidrug resistance(MDR) gene.... -
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- Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report
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Cha YJ, Ghim JL
- KMID: 2385963
- J Korean Med Sci.
- 2017 Sep;32(9):1542-1547.
- doi: 10.3346/jkms.2017.32.9.1542
Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms... -
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- Change of MDR Gene Expression and Glutathione Metabolism during Long Standing Low-dose Cisplatin Exposure in Bladder Carcinoma Cell Line
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Lee ES, Kim SW, Yoon SJ, Lee HW, Ahn HJ, Lee CW
- KMID: 1663273
- Korean J Urol.
- 1996 Dec;37(12):1345-1350.
Resistance to anticancer chemotherapeutic drugs remains a major obstacle in cancer chemotherapy. A variety of mechanisms responsible for drug resistance has been posed. Mdr gene overexpression and detoxification by glutathione... -
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- Expressions of cyclooxygenase-2 and P-glycoprotein in epithelial ovarian carcinomas
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Jung SK, Kang JS, Kim IS
- KMID: 2273175
- Korean J Obstet Gynecol.
- 2007 Sep;50(9):1205-1215.
OBJECTIVES: The purpose of this study was to evaluate expression of cyclooxygenase-2 (COX-2) and P-glycoprotein (P-gp) in ovarian epithelial carcinomas, to find out the correlations between their expression and clinicopathological... -
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- Development of an oligonucleotide microarray for simultaneous detection of two canine MDR1 genotypes and association between genotypes and chemotherapy side effects
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Lee JJ, Lin HY, Chen CA, Lin CS, Wang LC
- KMID: 2434774
- J Vet Sci.
- 2019 Jan;20(1):27-33.
- doi: 10.4142/jvs.2019.20.1.27
Canine MDR1 gene mutations produce translated P-glycoprotein, an active drug efflux transporter, resulting in dysfunction or over-expression. The 4-base deletion at exon 4 of MDR1 at nucleotide position 230 (nt230[del4])... -
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- Expression of P53, Bcl-2, Bax, and P-glycoprotein in Relation to Chemotherapeutic Response in Patients with Advanced Non-Small-Cell Lung Cance
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Park SY, Lee EH, Kim KW, Kay CS, Kim SC, Suhr JW, Lee KS
- KMID: 2174990
- J Korean Cancer Assoc.
- 2001 Apr;33(2):158-162.
PURPOSE: To evaluate the relationship between the expressions of p53, bcl-2, bax, and p-glycoprotein and the chemotherapeutic response seen in patients with advanced NSCLC. MATERIALS AND METHODS: Forty-four patients pathologically proven... -
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- Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability
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Lee W, Choi HI, Kim MJ, Park SY
- KMID: 1103594
- Exp Mol Med.
- 2008 Feb;40(1):109-117.
- doi: 10.3858/emm.2008.40.1.109
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not... -
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