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Acute Organophosphorus Pesticide Poisoning

Lee MJ, Park JS, Hong TY, Park SS, You YH

  • KMID: 2203436
  • J Korean Soc Clin Toxicol.
  • 2008 Dec;6(2):83-90.
Organophosphate (OP) pesticides are the most common source of human toxicity globally, causing high mortality and morbidity despite the availability of atropine as a specific antidote and oximes to reactivate...
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Isolation and Structure Determination of an Imidazo-pyrimidine, 5-Chlorocavernicolin, Maleimide oximes and Nucleosides from a Marine Sponge Extract

Kulkarni R, Kim JH, Kim YH, Oh S, Na M

In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation...
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A Case of Central Nervous System (CNS) Toxicity in Acute Organophosphate Intoxication

Lee JS, Paik JH, Yun SH, Kim JH, Han SB, Kim JS, Jung HM

  • KMID: 1482716
  • J Korean Soc Clin Toxicol.
  • 2013 Jun;11(1):31-35.
Acute organophosphate intoxication is important because of its high morbidity and mortality. The mortality is still high despite the use of atropine as specific antidotal therapy and oximes for reactivation...
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Methidathion Poisoning

Kim KH, Kim SH, Her C

Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution...
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Clinical Outcome for High-dose Pralidoxime in Treating Organophosphate Intoxication

Lee KM, Choi YH, Cheon YJ, Lee DH

  • KMID: 2101636
  • J Korean Soc Clin Toxicol.
  • 2011 Dec;9(2):56-60.
PURPOSE: The optimal dose of oximes for use in the treatment of organophosphorus pesticide poisoning has not been conclusively established. In this retrospective study, we assessed the effectiveness of the...
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Technetium-99m HM-PAO SPECT in patients with delayed neurologic sequelae after carbon monoxide poisoning

Choi IS, Lee MS, Lee YJ, Kim JH, Lee SS, Kim WT

We used single photon emission computed tomography (SPECT) with technetium-99m hexamethylpropylene amine oxime (99mTc-HM-PAO) in 14 studies on 6 patients with delayed neurologic sequelae from carbon monoxide (CO) poisoning...
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The Fine Scratches of the Spectacle Frames and the Allergic Contact Dermatitis

Kim IS, Yoo KH, Kim MN, Hong HK, Choi YS, Jo YC, Kim BJ, Lee JS

BACKGROUND: Spectacle contact allergy is not infrequent. The fine scratches on the spectacle frames which may play a role in the sensitization to the potential allergenic components have not been...
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Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis

Zhang J, Xu DL, Liu XB, Bi SJ, Zhao T, Sui SJ, Ji XP, Lu QH

PURPOSE: Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis. The principal aim of this study was to examine whether darapladib (a selective Lp-PLA2...
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Thalamic syndrome and cortical hypoperfusion on technetium-99m HM-PAO brain SPECT

Lee MS, Choi IS, Chung TS

The six patients included in this study had painful dysesthesia, resulting from vascular lesions in or near the thalamus, confirmed by computerized tomography(CT) brain scan. Using hexamethyl propyleneamine oxime(HM-PAO) single...
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O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes

Park SY, Ryu J, Lee W

  • KMID: 1056235
  • Exp Mol Med.
  • 2005 Jun;37(3):220-229.
It has been known that O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins plays an important role in transcription, translation, nuclear transport and signal transduction. The increased flux of glucose through the...
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