- Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis
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Wang Y, Lin L, Zheng C
- KMID: 1245261
- Exp Mol Med.
- 2012 Mar;44(3):177-190.
- doi: 10.3858/emm.2012.44.3.013
Orai1 is the key subunit of the Ca2+-release-activated Ca2+ channel. Our previous report has demonstrated that Orai1 expression in the airway was upregulated in the ovalbumin (OVA)-induced allergic rhinitis (AR)... -
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- Ovalbumin fused with diphtheria toxin protects mice from ovalbumin induced anaphylactic shock
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Lee BK, Yoo YG, Lee WY, Hong CS, Park JK, Ro JY
- KMID: 720592
- Yonsei Med J.
- 2001 Feb;42(1):91-105.
- doi: 10.3349/ymj.2001.42.1.91
For those with allergy, vaccination with a specific allergen has often been used as a major therapeutic measure. However, the universal application of this technique in clinics... -
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- Alveolar macrophages modulate allergic inflammation in a murine model of asthma
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Bang BR, Chun E, Shim EJ, Lee HS, Lee SY, Cho SH, Min KU, Kim YY, Park HW
- KMID: 1009966
- Exp Mol Med.
- 2011 May;43(5):275-280.
- doi: 10.3858/emm.2011.43.5.028
The role of alveolar macrophages (AMs) in the pathogenesis of asthma is still unknown. The aim of the present study was to investigate the effects of AM in the murine... -
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- TGF-beta-treated antigen presenting cells suppress collagen-induced arthritis through the promotion of Th2 responses
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Jung S, Park YK, Lee H, Shin JH, Lee GR, Park SH
- KMID: 946651
- Exp Mol Med.
- 2010 Mar;42(3):187-194.
- doi: 10.3858/emm.2010.42.3.019
Collagen-induced arthritis (CIA) is mediated by self-reactive CD4+ T cells that produce inflammatory cytokines. TGF-beta2-treated tolerogenic antigen-presenting cells (Tol-APCs) are known to induce tolerance in various autoimmune diseases. In this... -
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- Change of connexin 37 in allergen-induced airway inflammation
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Park SJ, Lee KS, Kim SR, Min KH, Lee KY, Choe YH, Park SY, Hong SH, Lee YC
- KMID: 1090966
- Exp Mol Med.
- 2007 Oct;39(5):629-640.
Gap junction channels formed with connexins directly link to the cytoplasm of adjacent cells and have been implicated in intercellular signaling. Connexin 37 (Cx37) is expressed in the gas-exchange region... -
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- Proteomic Analysis of Differently Expressed Proteins in a Mouse Model for Allergic Asthma
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Jeong HS, Rhim TY, Ahn MH, Yoon PO, Kim SH, Chung IY, Uh ST, Kim SI, Park CS
- KMID: 1712736
- J Korean Med Sci.
- 2005 Aug;20(4):579-585.
- doi: 10.3346/jkms.2005.20.4.579
Allergic asthma is associated with persistent functional and structural changes in the airways and involves many different cell types. Many proteins involved in allergic asthma have been identified individually, but... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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- A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha
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Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Han HJ, Lee YR, Kim JS, Atlas D, Lee YC
- KMID: 1091070
- Exp Mol Med.
- 2007 Dec;39(6):756-768.
Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity... -
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