- The Effect of CpG Oligonucleotides on the Allergic Inflammation in Asthma
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- KMID: 2299559
- Korean J Asthma Allergy Clin Immunol.
- 2009 Sep;29(3):164-165.
No abstract available. -
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- Introduction of Radiolabeled Therapeutic Oligonucleotides As Nanonuclear Explosive Gene Therapy
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Choe JG, Lee HY, Park GH, Ryu CK, Kim MK
- KMID: 1623976
- Korean J Nucl Med.
- 2001 Jun;35(3):125-130.
No abstract available. -
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- Azasugar Nucleotide-containing Phosphorothioate Oligonucleotides as an AIDS Therapeutic Drug
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Lee DS, Lim H, Bae YS
- KMID: 1573026
- J Bacteriol Virol.
- 2002 Jun;32(2):165-176.
A series of modified oligonucleotides containing P=S backbone and a six-membered azasugar (6-AZS) were synthesized and tested for their ability to inhibit human immunodeficiency virus (HIV) in vitro without the... -
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- Molecular Approaches for Brain Tumor Therapy;Gene Transfer and Anti-sense Oligonucleotides
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Hong YK
- KMID: 1955357
- J Korean Neurosurg Soc.
- 1996 Sep;25(9):1815-1819.
Despite advances in neurosurgery, radiation, and chemotherapy, the prognosis of patients with malignant brain tumors still remains grim. Considerable efforts have been made to develop new therapeutic strategies for malignant... -
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- Cholesterol conjugated spermine as a delivery modality of antisense oligonucleotide
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Im YK, Kim MS, Yoo H
- KMID: 1709609
- Int J Oral Biol.
- 2013 Dec;38(4):155-160.
The major issue in the development of nucleic acid based therapeutics is the inefficient delivery of these agents into cells. We prepared cholesterol conjugated spermine and evaluated its usefulness as... -
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- Efficacy and Safety of an Oral SMAD7 Antisense Drug for Active Crohn's Disease
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Seo GS
- KMID: 2373243
- Korean J Gastroenterol.
- 2015 Jun;65(6):384-385.
- doi: 10.4166/kjg.2015.65.6.384
No abstract available. -
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- The Role of NF-kappaB RelA Subunit for Tax-inhibition of p53 Transcriptional Activity in Human T-cell Lymphotrophic Virus Type 1
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Jeong SJ, Lee JD, Jeong MH
- KMID: 1963271
- J Bacteriol Virol.
- 2004 Sep;34(3):231-237.
Human T-cell lymphotrophic virus type I (HTLV-I) is a causative agent of adult T-cell leukemia (ATL). The viral transcriptional activator Tax encoded by the HTLV-I genome is thought to play... -
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- Retrotransposon Microsatellite Amplified Polymorphism Strain Fingerprinting Markers Applicable to Various Mushroom Species
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Le QV, Won HK, Lee TS, Lee CY, Lee HS, Ro HS
- KMID: 1487337
- Mycobiology.
- 2008 Sep;36(3):161-166.
- doi: 10.4489/MYCO.2008.36.3.161
The retrotransposon marY1 is a gypsy family retroelement, which is detected ubiquitously within the fungal taxonomic groups in which mushrooms are included. To utilize marY1 as a molecular marker for... -
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- The effect of YB-1 antisense oligonucleotides on tumor cell growth
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Kim MS, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Jung YD, Kim SJ, Ahn BW, Shin BA
- KMID: 2081228
- Korean J Med.
- 2006 Sep;71(3):293-301.
BACKGROUND: Human YB-1 is a transcription factor that binds to the inverted CCAAT box in the promoter region of a variety of genes such as PCNA, DNA polymerase and MDR.... -
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- Downregulation of TGF-beta1 Expression in Penile Corpus Cavernosum by Antisense TGF-beta1 Oligonucleotides in Diabetic Rat
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Park KS, Kim MK, Lee SE, Jin MY, Kim KK, Shin BA, Ahn KY
- KMID: 1859359
- Korean J Androl.
- 2001 Dec;19(3):189-194.
PURPOSE: We investigated the effect of antisense TGF-beta1 oligonucleotides on the expression of TGF-beta1 in the penile corpus cavernosum of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Forty Sprague-Dawley male rats (200-210... -
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- RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment
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Hong S
- KMID: 2434281
- J Cancer Prev.
- 2017 Dec;22(4):203-210.
- doi: 10.15430/JCP.2017.22.4.203
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to perform biological activities. RBPs can interact with target RNAs in sequence- and structure-dependent manner through their unique RNA... -
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- The Effects of TGF-beta2 and bFGF on the Proliferation of Retinal Pigment Epithelial Cells
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Yoon HS, Roh SH, Lee SC, Jeong JH, Yoo YH
- KMID: 2123999
- J Korean Ophthalmol Soc.
- 1998 Jun;39(6):1192-1203.
This study was undertaken to document the effect of transforming growth factor-beta2 (TGF-beta2(TGF-beta2) and basic fibroblast growth factor (bFGF) on the proliferation of pig retinal pigment epithelial cells (RPE). Whereas... -
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- Gene Therapy for Muscular Dystrophies: Progress and Challenges
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Park KS, Oh D
- KMID: 1462846
- J Clin Neurol.
- 2010 Sep;6(3):111-116.
- doi: 10.3988/jcn.2010.6.3.111
Muscular dystrophies are groups of inherited progressive diseases of the muscle caused by mutations of diverse genes related to normal muscle function. Although there is no current effective treatment for... -
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- Comparison Between HLA-DR Serological Typing and O1igotyping
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Wee JH, Jeong KC, Kim TG, Han JY, Kim JM
- KMID: 2146210
- Korean J Clin Pathol.
- 1997 Dec;17(6):1089-1099.
BACKGROUND: In renal transplantation, a good HLA-DR match Is associated with successive graft outcome. But due to a number of technical problems, reliable serological DR typing cannot always be obtained.... -
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- Antiviral Effect of Antisense Phosphorothioate Oligonucleotides Targeted to Herpes Simplex Virus
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Lee YC, Kim SJ, Cho YJ
- KMID: 2146905
- J Korean Soc Microbiol.
- 1999 Jun;34(3):233-243.
To search the effective antisense oligonucleotide that inhibit the growth of Herpes simplex virus type 1 (HSV-1), six kinds of phosphorothioate oligodeoxynucleotides (S-ODNs) were synthesized and the antiviral activity was... -
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- Development of Covalently Closed c-myb Antisense Oligonucleotides for Growth Inhibition of Leukemic Cells
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Moon IM, Park JG
- KMID: 2175232
- J Korean Cancer Assoc.
- 1999 Apr;31(2):348-359.
PURPOSE: Aberrant expression of the c-myb gene is often detected in transformed leukemic cells. Inhibition of c-myb expression by antisense oligos could be an effective way to abort rapid growth... -
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- Effective Inhibition of Cancer Cell Growth by a Novel Tripartite Transfection Complex Containing Ribbon Antisense Molecules to hTR
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Park JG
- KMID: 1804566
- Cancer Res Treat.
- 2004 Oct;36(5):308-314.
PURPOSE: In the present study, ribbon antisense to the hTR RNA, a component of the telomerase complex, was employed to inhibit telomerase activity and cancer cell growth. MATERIALS AND METHODS:... -
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- Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction
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Jang MA, Lee ST, Oh YL, Kim SW, Chung JH, Ki CS, Kim JW
- KMID: 1381693
- Ann Lab Med.
- 2012 May;32(3):238-241.
- doi: 10.3343/alm.2012.32.3.238
Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, and 36-69% of PTC cases are caused by mutations in the BRAF gene. The substitution of a valine for... -
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- Study on the Mitochondrial Dysfunction by p53 Regulation in Ceramide-induced Neuronal Cell Death
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Lee DY, Lee HJ, Noh YH, Yun JY, Han IS, Chung YH, Kim KY, Kim SS, Lee WB
- KMID: 1512990
- Korean J Phys Anthropol.
- 2006 Mar;19(1):49-59.
Ceramide induces cell death in a dose- and time-dependent manner in neuroblastoma SK-N-SH cells. To investigate the mechanism of SK-N-SH cell death by C2-ceramide, morphological features and Hoechst 33258 staining... -
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- Involvement of NAD (P) H Oxidase in a Potential Link between Diabetes and Vascular Smooth Muscle Cell Proliferation
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Jeong HY, Yun MR, Kim CD
- KMID: 2285284
- Korean J Physiol Pharmacol.
- 2003 Apr;7(2):103-110.
The cellular mechanisms that contribute to the acceleration of atherosclerosis in diabetes are poorly understood. Therefore, the potential mechanisms involved in the diabetes-dependent increase in vascular smooth muscle cell (VSMC)... -
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