- Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions
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Anderson J
- KMID: 2070073
- Gut Liver.
- 2014 Nov;8(6):582-589.
- doi: 10.5009/gnl14248
Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in... -
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- Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing
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Zhao Q, Yang J, Li L, Cao D, Yu M, Shen K, the BGI Group
- KMID: 2413427
- J Gynecol Oncol.
- 2017 Jul;28(4):e39.
- doi: 10.3802/jgo.2017.28.e39
OBJECTIVE: To define genetic profiling of homologous recombination (HR) deficiency in Chinese ovarian cancer patients. METHODS: we have applied next-generation sequencing to detect deleterious mutations through all exons in 31 core... -
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- HNF1 and/or HNF3 may contribute to the tissue specific expression of glucokinase gene
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Cha JY, Kim HI, Im SS, Li TZ, Ahn YH
- KMID: 1085740
- Exp Mol Med.
- 2001 Jun;33(2):59-63.
A possible role of hepatocyte nuclear factor 1 (HNF1) or HNF3, a predominant trans-acting factors of hepatic or pancreatic beta-cells, was examined on the tissue specific interdependent expression of glucokinase... -
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- Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma
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Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ
- KMID: 1113480
- Korean J Gastroenterol.
- 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA... -
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- Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer
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Shin JY, Kim HS, Lee KS, Kim JB, Park JB, Won MH, Chae SW, Choi YH, Choi KC, Park YE, Lee JY
- KMID: 1109306
- Exp Mol Med.
- 2000 Jun;32(2):79-83.
Cyclin-dependent kinase inhibitors (CDKI) are negative regulators of cell cycle progression by binding the cyclin-CDK complex and inhibiting the CDK activity. Genetic alteration in the CDKI genes has been implicated... -
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- Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability
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Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC
- KMID: 1785795
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S91-S97.
- doi: 10.3346/jkms.2007.22.S.S91
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history... -
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- Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells
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Cho YM, Jang YS, Jang YM, Chung SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim JJ, Kim KS, Kwon OJ
- KMID: 756236
- Exp Mol Med.
- 2009 Jun;41(6):440-452.
- doi: 10.3858/emm.2009.41.6.049
When we treated rat bone marrow stromal cells (rBMSCs) with neuronal differentiation induction media, typical unfolded protein response (UPR) was observed. BIP/GRP78 protein expression was time-dependently increased, and three branches... -
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- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
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Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
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- Microarray for Genes Associated with Signal Transduction in Diabetic OLETF Keratocytes
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Lee JE, Lee JS, Hwang SH
- KMID: 1101914
- Korean J Ophthalmol.
- 2007 Jun;21(2):111-119.
- doi: 10.3341/kjo.2007.21.2.111
PURPOSE: The purpose of this study was to identify differences in signal transduction gene expression between normal and diabetic keratocytes stimulated with interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha). ... -
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- High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients
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Choe WH, Lee SY, Lee JH, Shim SG, Kim YH, Rhee PL, Rhee JC, Ki CS, Kim JW, Song SY, Kim JJ
- KMID: 1718032
- Korean J Intern Med.
- 2005 Jun;20(2):116-122.
- doi: 10.3904/kjim.2005.20.2.116
BACKGROUND: Although there have been some reports on microsatellite alterations in gastric cancer, findings are inconsistent regarding the associations between histological classification and microsatellite instability (MSI). In the present study,... -
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- Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells
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He YQ, Sheng JQ, Ling XL, Fu L, Jin P, Yen L, Rao J
- KMID: 1402316
- Exp Mol Med.
- 2012 Dec;44(12):723-732.
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.... -
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- Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid beta-peptide toxicity
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Kim JR, Lee SR, Chung HJ, Kim S, Baek SH, Kim JH, Kim YS
- KMID: 1093613
- Exp Mol Med.
- 2003 Oct;35(5):403-411.
Amyloid beta-peptide (Abeta), a causative molecule in the pathogenesis of Alzheimer's disease and the main component of senile plaques, is known to be neurotoxic in vitro and in vivo. The... -
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- DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma
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Hong SH, Kim HG, Chung WB, Kim EY, Lee JY, Yoon SM, Kwon JG, Sohn YK, Kwak EK, Kim JW
- KMID: 1095197
- J Korean Med Sci.
- 2005 Apr;20(2):236-241.
- doi: 10.3346/jkms.2005.20.2.236
The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair... -
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- Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury
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Lee MJ, Kwak YK, You KR, Lee BH, Kim DG
- KMID: 1088599
- Exp Mol Med.
- 2009 Apr;41(4):243-252.
- doi: 10.3858/emm.2009.41.4.027
Oxidative stress is critical for causing cardiac injuries during ischemia-reperfusion (IR), yet the molecular mechanism for this remains unclear. In the present study, we observe that hypoxia and reoxygenation, a... -
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- Delayed allograft rejection by the suppression of class II transactivator
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Kim TW, Choi YM, Seo JN, Kim JH, Suh YH, Chung DH, Jung KC, Oh KI
- KMID: 1094146
- Exp Mol Med.
- 2006 Jun;38(3):210-216.
We examined the effect of class II transactivator (CIITA) down-modulation on allograft rejection. To inhibit the function of CIITA, we constructed a series of CIITA mutants and found one exhibiting... -
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- Association of DNA-dependent protein kinase with hypoxia induciblefactor-1 and its implication inresistance to anticancer drugs in hypoxic tum or cells
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Um JH, Kang CD, Bae JH, Shin GG, Kim DW, Kim DW, Chung BS, Kim SH
- KMID: 1097105
- Exp Mol Med.
- 2004 Jun;36(3):233-242.
Tumor hypoxia contributes to the progression of a malignant phenotype and resistance to ionizing radiation and anticancer drug therapy. Many of these effects in hypoxic tumor cells are mediated by... -
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- Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin
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Kang BS, Ahn JY, Kim MK, Kim HJ, Kang L, Lim HC, Park KS, Lee JS, Seo JS, Cha CI, Kim SU, Park YJ, Kim M
- KMID: 1103679
- Exp Mol Med.
- 2007 Feb;39(1):38-46.
Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal system, where proteolytic fragments of... -
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