- IDH2 gene deficiency accelerates unilateral ureteral obstructioninduced kidney inflammation through oxidative stress and activation of macrophages
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Kim JI, Noh MR, Yoon GE, Jang HS, Kong MJ, Park KM
- KMID: 2512957
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):139-146.
- doi: 10.4196/kjpp.2021.25.2.139
Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the... -
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- Rac1 inhibition protects the kidney against kidney ischemia/ reperfusion through the inhibition of macrophage migration
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Park YR, Kong MJ, Noh MR, Park KM
- KMID: 2541637
- Korean J Physiol Pharmacol.
- 2023 May;27(3):257-265.
- doi: 10.4196/kjpp.2023.27.3.257
Kidney ischemia/reperfusion (I/R) injury, a common cause of acute kidney injury (AKI), is associated with the migration of inflammatory cells into the kidney. Ras-related C3 botulinum toxin substrate 1 (Rac1),... -
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- Extraneural CGRP Induces Oxidative Stress in Kidney Proximal Tubule Epithelial Cells
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Moon D, Yoon SP, Jang HS, Noh MR, Ha L, Padanilam , Kim J
- KMID: 2467465
- Anat Biol Anthropol.
- 2019 Dec;32(4):121-128.
- doi: 10.11637/aba.2019.32.4.121
Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in primary afferent sensory neurons. Exogenous CGRP can induce cell death in kidney tubular cells. The objective of this study was... -
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