- Expression of nitric oxide synthase isoforms in the porcine ovary during follicular development
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Kim H, Moon C, Ahn M, Lee Y, Kim H, Kim S, Ha T, Jee Y, Shin T
- KMID: 1114849
- J Vet Sci.
- 2005 Jun;6(2):97-101.
The expression of nitric oxide synthase (NOS) isoforms in the ovaries of pigs was examined to study the involvement of nitric oxide, a product of NOS activity, in the function... -
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- Induction of nitric oxid esynthase(NOS) by soluble glucocorticoid induced tumor necrosis factor receptor(sGITR) is modulated by IFN-g in murine macrophage
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Shin HH, Lee HW, Choi HS
- KMID: 1094698
- Exp Mol Med.
- 2003 Jun;35(3):175-180.
Earlier study showed that glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, activated murine macrophages to express inducible nitric oxide synthase (iNOS) and to generate nitric oxide... -
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- Expression of Inducible Nitric Oxide Synthase Is Increased in Rat Barrett's Esophagus Induced by Duodenal Contents Reflux
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Bae JD, Jung KH, Ahn WS, Bae SH, Jang TJ
- KMID: 1781725
- J Korean Med Sci.
- 2005 Feb;20(1):56-60.
- doi: 10.3346/jkms.2005.20.1.56
Barrett's esophagus is a premalignant condition of esophageal adenocarcinoma. Inducible nitric oxide synthase (iNOS) is induced by cytokines and can generate locally high concentrations of nitric oxide (NO), whose metabolites... -
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- The role of nitric oxide as an effector of macrophage-mediated cytotoxicity against Trichomonas vaginalis
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Park GC, Ryu JS, Min DY
- KMID: 658271
- Korean J Parasitol.
- 1997 Sep;35(3):189-195.
- doi: 10.3347/kjp.1997.35.3.189
The purpose of this study is to determine whether nitric oxide is involved in the extracellular killing of Trichomonas vaginalis by mouse (BALB/c) peritoneal macrophages and RAW264.7 cells... -
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- Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats
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Shin S, Na S, Kim OS, Choi YS, Kim SH, Oh YJ
- KMID: 2466376
- Yonsei Med J.
- 2016 Jan;57(1):238-246.
- doi: 10.3349/ymj.2016.57.1.238
PURPOSE: Oxidative stress during CO2 pneumoperitoneum is reported to be associated with decreased bioactivity of nitric oxide (NO). However, the changes in endothelial nitric oxide synthase (eNOS), inducible nitric oxide... -
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- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
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Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
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- Effect of Nitric Oxide on the Cryopreservation of Platelets
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Lee JH, Kim JT, Cho YG
- KMID: 854846
- Korean J Lab Med.
- 2008 Apr;28(2):136-143.
- doi: 10.3343/kjlm.2008.28.2.136
BACKGROUND: To determine whether nitric oxide (NO) could inhibit activation of platelets stored in a cold or frozen state, we measured platelet P-selectin expression and platelet-bound fibrinogen in platelet-rich... -
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- Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells
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Lee JA, Song HY, Ju SM, Lee SJ, Kwon HJ, Eum WS, Jang SH, Choi SY, Park J
- KMID: 756206
- Exp Mol Med.
- 2009 Sep;41(9):629-637.
- doi: 10.3858/emm.2009.41.9.069
Inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) have been known to be involved in various pathophysiological processes such as inflammation. This study was performed to determine the regulatory... -
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- The Role of Nitric Oxide in Experimental Cerulein Induced Pancreatitis
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Um SH, Kwon YD, Kim CD, Lee HS, Jeen YT, Chun HJ, Lee SW, Choi JH, Ryu HS, Hyun JH
- KMID: 648903
- J Korean Med Sci.
- 2003 Aug;18(4):520-526.
- doi: 10.3346/jkms.2003.18.4.520
An enhanced formation of nitric oxide(NO), due to the induction of inducible nitric oxide synthase(iNOS), has been implicated in the pathogenesis of shock and inflammation, but its role in acute... -
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- Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes
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Yang JY, Koo BS, Kang MK, Rho HW, Sohn HS, Jhee EC, Park JW
- KMID: 755207
- Exp Mol Med.
- 2002 Nov;34(5):353-360.
The present study was undertaken to explore whether retinoids, which are known to have immunomodulatory actions, could attenuate tumor necrosis factor-alpha (TNF)-stimulated inducible nitric oxide synthase (iNOS) expression in 3T3-L1... -
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- Erythropoietin does not affect nitric oxide system in rats with chronic renal failure
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Kim SW, Lee JU, Kang DG, Jung K, Kim NH, Suh SP, Choi KC, Kang YJ
- KMID: 648121
- J Korean Med Sci.
- 2000 Apr;15(2):183-188.
- doi: 10.3346/jkms.2000.15.2.183
We investigated to see whether an altered role of nitric oxide (NO) system is involved in erythropoietin (EPO)-induced hypertension in chronic renal failure (CRF). Male Sprague-Dawley rats were five-sixths nephrectomized... -
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- The stimulatory effect of IL-1beta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway
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Jeong IK, Oh SH, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 1093592
- Exp Mol Med.
- 2002 Mar;34(1):12-17.
Interleukin 1 (IL-1) is a pleiotropic cytokine with the potential to destroy pancreatic beta-cells, and thought to be involved in the pathogenesis of type I diabetes mellitus. Expression of inducible... -
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- Upregulation of Proinflammatory Cytokines in the Fetal Brain of the Gaucher Mouse
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Hong YB, Kim EY, Jung SC
- KMID: 2157830
- J Korean Med Sci.
- 2006 Aug;21(4):733-738.
- doi: 10.3346/jkms.2006.21.4.733
Gaucher disease is caused by a deficiency of glucocerebrosidase. Patients with Gaucher disease are divided into three major phenotypes: chronic nonneuronopathic, acute neuronopathic, and chronic neuronopathic, based on symptoms of... -
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- Anti-Inflammatory Effect of Near-Infrared Irradiated Cell Culture Media
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Kim SG, Shin IH, Choi CH, Choe JY
- KMID: 1096928
- Korean J Lab Med.
- 2009 Aug;29(4):338-344.
- doi: 10.3343/kjlm.2009.29.4.338
BACKGROUND: Near-infrared light (NIR, 0.8-1.5 micrometer light) has been used in therapeutic devices for various injuries such as infected, ischemic and hypoxic wound. NIR-emitting technology has been developed recently in... -
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- Nitric oxide mediates epinephrine-induced apoptotic cell death of trabecular meshwork cells in vitro
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Kim JW, Kim SK, Kim KH
- KMID: 1037764
- Korean J Ophthalmol.
- 2003 Dec;17(2):97-105.
- doi: 10.3341/kjo.2003.17.2.97
To evaluate the effect of epinephrine on the cellular proliferation and production of nitric oxide (NO) in trabecular meshwork (TM) cells, cultured porcine TM cells were exposed to epinephrine at... -
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- Effects of prednisolone on eosinophils, IL-5, eosinophil cationic protein, EG2+ eosinophils, and nitric oxide metabolites in the sputum of patients with exacerbated asthma
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Jang AS, Choi IS, Koh YI, Jeong TK, Lee KY, Kim YS, Lee JU, Park CS
- KMID: 965873
- J Korean Med Sci.
- 2000 Oct;15(5):521-528.
- doi: 10.3346/jkms.2000.15.5.521
Corticosteroids are considered to be one of the most effective medicine for asthma by suppressing airway inflammation. This study was carried out to investigate the effects of prednisolone in the... -
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- The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure
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Lee MS, Moon KY, Bae DJ, Park MK, Jang AS
- KMID: 1501777
- Korean J Intern Med.
- 2013 Mar;28(2):216-223.
- doi: 10.3904/kjim.2013.28.2.216
BACKGROUND/AIMS: Ozone is an environmentally reactive oxidant, and pycnogenol is a mixture of flavonoid compounds extracted from pine tree bark that have antioxidant activity. We investigated the effects of pycnogenol... -
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- Oxygen-Dependent and -Independent Regulation of HIF-1alpha
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Chun YS, Kim MS, Park JW
- KMID: 1127245
- J Korean Med Sci.
- 2002 Oct;17(5):581-588.
- doi: 10.3346/jkms.2002.17.5.581
Hypoxia-inducible factor-1 (HIF-1) is composed of HIF-1alpha and HIF-1beta, and is a master regulator of oxygen homeostasis, playing critical roles in physiological and pathological processes. Normally, the formation and... -
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- Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
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Chung BH, Kim S, Kim JD, Lee JJ, Baek YY, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM
- KMID: 1245262
- Exp Mol Med.
- 2012 Mar;44(3):191-201.
- doi: 10.3858/emm.2012.44.3.014
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in vascular functions, including vasorelaxation. We here investigated the pharmacological effect of the natural product syringaresinol on... -
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- Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
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Lee KM
- KMID: 1115949
- Exp Mol Med.
- 2006 Dec;38(6):703-717.
Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these... -
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