- Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice
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Nguyen MC, Ryoo S
- KMID: 2371071
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):83-90.
- doi: 10.4196/kjpp.2017.21.1.83
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the... -
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- Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation
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Nguyen MC, Park JT, Jeon YG, Jeon BH, Hoe KL, Kim YM, Lim HK, Ryoo S
- KMID: 2427149
- Yonsei Med J.
- 2016 Nov;57(6):1329-1338.
- doi: 10.3349/ymj.2016.57.6.1329
PURPOSE: Peroxynitrite plays a critical role in vascular pathophysiology by increasing arginase activity and decreasing endothelial nitric oxide synthase (eNOS) activity. Therefore, the aims of this study were to investigate... -
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