- Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction
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Nguyen G, Park SY, Do DV, Choi DH, Cho EH
- KMID: 2537292
- Endocrinol Metab.
- 2022 Dec;37(6):918-928.
- doi: 10.3803/EnM.2022.1530
Background: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) are used clinically as oral antidiabetic agents. Although DPP-4Is are known to ameliorate liver fibrosis, the protective mechanism of DPP-4Is in liver fibrosis remains obscure.... -
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- Phloretin Ameliorates Succinate-Induced Liver Fibrosis by Regulating Hepatic Stellate Cells
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Le CT, Nguyen G, Park SY, Dong HN, Cho YK, Lee JH, Im SS, Choi DH, Cho EH
- KMID: 2545272
- Endocrinol Metab.
- 2023 Aug;38(4):395-405.
- doi: 10.3803/EnM.2023.1661
Background: Hepatic stellate cells (HSCs) are the major cells which play a pivotal role in liver fibrosis. During injury, extracellular stimulators can induce HSCs transdifferentiated into active form. Phloretin showed... -
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- Succinate Induces Liver Damage and Hepatic Fibrosis in a Mouse Model
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Le CT, Nguyen G, Dong HN, Park SY, Cho YK, Choi DH, Park WS, Lee Y, Lee JY, Cho EH
- KMID: 2536901
- Keimyung Med J.
- 2022 Dec;41(2):84-91.
- doi: 10.46308/kmj.2022.00143
Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved in the activation, proliferation, and migration of HSCs. We investigated... -
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- Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction
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Lai TL, Park SY, Nguyen G, Pham PTM, Kang SM, Hong J, Lee JH, Im SS, Choi DH, Cho EH
- KMID: 2562719
- Endocrinol Metab.
- 2024 Dec;39(6):908-920.
- doi: 10.3803/EnM.2024.1984
Background: Liver fibrosis is a common outcome of chronic liver disease and is primarily driven by hepatic stellate cell (HSC) activation. Irisin, a myokine released during physical exercise, is beneficial... -
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