- Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis
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Moon C, Shin T
- KMID: 1093622
- J Vet Sci.
- 2004 Dec;5(4):289-293.
To investigate the pattern of expression of osteopontin (OPN) in tissues of the central nervous system (CNS) responding to peripheral immunological stimulation, the expression of OPN was studied in the... -
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- Efficient Induction of Dopaminergic Neurons from Embryonic Stem Cells for Application to Parkinson's Disease
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Kim DW
- KMID: 1726141
- Yonsei Med J.
- 2004 Jun;45(Suppl):S23-S27.
- doi: 10.3349/ymj.2004.45.Suppl.23
For cell replacement therapy of neurodegenerative diseases such as Parkinson's disease (PD), methods for efficiently generating midbrain dopaminergic (DA) neurons from embryonic stem (ES) cells have been investigated. Two aspects... -
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- The Expression of Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala, Induced by Colorectal Distension, is Attenuated by General Anesthesia
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Kim SH, Han JE, Hwang S, Oh DH
- KMID: 1779236
- J Korean Med Sci.
- 2010 Nov;25(11):1646-1651.
- doi: 10.3346/jkms.2010.25.11.1646
Corticotrophin-releasing factor (CRF), a key regulator of the hypothalamic-pituitary axis, is expressed in the central nucleus of the amygdala (CeA) and its expression is upregulated in stress-related disorders. We investigated... -
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- Anti-oxidative neuroprotection by estrogens in mouse cortical cultures
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Bae YH, Hwang JY, Kim YH, Koh JY
- KMID: 1128633
- J Korean Med Sci.
- 2000 Jun;15(3):327-336.
- doi: 10.3346/jkms.2000.15.3.327
Estrogen replacement therapy in postmenopausal women may reduce the risk of Alzheimer's disease, possibly by ameliorating neuronal degeneration. In the present study, we examined the neuroprotective spectrum of estrogen against... -
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- Molecular Motor Proteins of the Kinesin Superfamily Proteins (KIFs): Structure, Cargo and Disease
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Seog DH, Lee DH, Lee SK
- KMID: 1785685
- J Korean Med Sci.
- 2004 Feb;19(1):1-7.
- doi: 10.3346/jkms.2004.19.1.1
Intracellular organelle transport is essential for morphogenesis and functioning of the cell. Kinesins and kinesin-related proteins make up a large superfamily of molecular motors that transport cargoes such as vesicles,... -
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- Homogenous fetal dopaminergic cell transplantation in rat striatum by cell suspension methods
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Chung SS, Kim SH, Yang WI, Choi IJ, Lee WY, Moon JG, Park HS, Shin HS, Kim DS, Ahn YM
- KMID: 1729602
- Yonsei Med J.
- 1993 Jun;34(2):145-151.
- doi: 10.3349/ymj.1993.34.2.145
The transplantation of dopaminergic neurons in the brain has been attempted in experimental animals and humans as the new treatment modality of Parkinson's disease. Before the trial of dopaminergic neuronal... -
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- Effects of MK-801 (dizocilpine) on Brain Cell Membrane Function and Energy Metabolism in Experimental Escherichia coli Meningitis in the Newborn Piglet
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Ko SY, Shim JW, Kim SS, Kim MJ, Chang YS, Park WS, Shin SM, Lee MH
- KMID: 2157628
- J Korean Med Sci.
- 2003 Apr;18(2):236-241.
- doi: 10.3346/jkms.2003.18.2.236
We evaluated the efficacy of non-competitive N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) as an adjuvant therapy in experimental neonal bacterial meningitis. Meningitis was induced by injecting 10(6) colony forming units of... -
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- TWIK-Related Spinal Cord K+ Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation
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Hwang HY, Zhang E, Park S, Chung W, Lee S, Kim DW, Ko Y, Lee W
- KMID: 2163622
- Yonsei Med J.
- 2015 Sep;56(5):1307-1315.
- doi: 10.3349/ymj.2015.56.5.1307
PURPOSE: The TWIK-related spinal cord K+ channel (TRESK) has recently been discovered and plays an important role in nociceptor excitability in the pain pathway. Because there have been no reports... -
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- Nonspecific association of 2',3'-cyclic nucleotide 3'-phosphodiesterase with the rat forebrain postsynaptic density fraction
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Cho SJ, Jung JS, Shin SC, Jin IN, Ko BH, Kim Kwon Y, Suh-Kim H, Moon IS
- KMID: 1119329
- Exp Mol Med.
- 2003 Dec;35(6):486-493.
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), a protein of unknown function in vivo, is abundantly expressed in myelinating glia in two isoforms, CNP1 and CNP2. In this study, immunoblot analysis showed... -
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- Pharmacotherapy for Alcohol Dependence: Anticraving Medications for Relapse Prevention
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Jung YC, Namkoong K
- KMID: 1110738
- Yonsei Med J.
- 2006 Apr;47(2):167-178.
- doi: 10.3349/ymj.2006.47.2.167
Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors. Relapse prevention for alcohol dependence has traditionally involved psychosocial and psychotherapeutic interventions. Pharmacotherapy,... -
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- A Gene and Neural Stem Cell Therapy Platform Based on Neuronal Cell Type-Inducible Gene Overexpression
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Oh J, You Y, Yun Y, Lee HL, Yoon DH, Lee M, Ha Y
- KMID: 2366346
- Yonsei Med J.
- 2015 Jul;56(4):1036-1043.
- doi: 10.3349/ymj.2015.56.4.1036
PURPOSE: Spinal cord injury (SCI) is associated with permanent neurological damage, and treatment thereof with a single modality often does not provide sufficient therapeutic outcomes. Therefore, a strategy that combines... -
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- Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex
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Jeon WJ, Kim SH, Seo MS, Kim Y, Kang UG, Juhnn YS, Kim YS
- KMID: 1094123
- Exp Mol Med.
- 2008 Aug;40(4):435-444.
- doi: 10.3858/emm.2008.40.4.435
Repeated electroconvulsive seizure (ECS), a model for electroconvulsive therapy (ECT), exerts neuroprotective and proliferative effects in the brain. This trophic action of ECS requires inhibition of apoptotic activity, in addition... -
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- Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
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Lee HG, Won SM, Gwag BJ, Lee YB
- KMID: 991618
- Exp Mol Med.
- 2011 Jan;43(1):7-14.
- doi: 10.3858/emm.2011.43.1.001
The possibility that P2X7 receptor (P2X7R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer's disease (AD).... -
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- Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
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Guo YS, Wu DX, Wu HR, Wu SY, Yang C, Li B, Bu H, Zhang YS, Li CY
- KMID: 1123461
- Exp Mol Med.
- 2009 Mar;41(3):140-150.
- doi: 10.3858/emm.2009.41.3.017
A subset of patients of amyotrophic lateral sclerosis (ALS) present with mutation of Cu/Zn superoxide dismutase 1 (SOD1), and such mutants caused an ALS-like disorder when expressed in rodents. These... -
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- Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development
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Kim JS, Kim J, Kim Y, Yang M, Jang H, Kang S, Kim JC, Kim SH, Shin T, Moon C
- KMID: 1067330
- J Vet Sci.
- 2011 Mar;12(1):1-6.
- doi: 10.4142/jvs.2011.12.1.1
Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development. The present study examined the temporal changes... -
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- Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription
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Sweatt JD
- KMID: 2154240
- Exp Mol Med.
- 2013 May;45(5):e21.
TCF4 (transcription factor 4; E2-2, ITF2) is a transcription factor that when haplo-insufficient causes Pitt-Hopkins Syndrome (PTHS), an autism-spectrum disorder that is associated with pervasive developmental delay and severe intellectual... -
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- The Effect of Treadmill Exercise on Ischemic Neuronal Injury in the Stroke Animal Model: Potentiation of Cerebral Vascular Integrity
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Kang KA, Seong H, Jin HB, Park J, Lee J, Jeon JY, Kim YJ
- KMID: 1754161
- J Korean Acad Nurs.
- 2011 Apr;41(2):197-203.
- doi: 10.4040/jkan.2011.41.2.197
PURPOSE: This study was done to identify whether pre-conditioning exercise has neuroprotective effects against cerebral ischemia, through enhance brain microvascular integrity. METHODS: Adult male Sprague-Dawley rats were randomly divided into four... -
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- Effect of Ketamine on Apoptosis by Energy Deprivation in Astroglioma Cells using Flow Cytometry System
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Choi SJ, Kim MH, Lim SW, Gwak MS
- KMID: 1781737
- J Korean Med Sci.
- 2005 Feb;20(1):113-120.
- doi: 10.3346/jkms.2005.20.1.113
Apoptosis is a programmed, physiologic mode of cell death that plays an important role in tissue homeostasis. As for the central nervous system, ischemic insults can induce pathophysiologic cascade of... -
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- Triamcinolone Acetonide Prevents Enhancement of Hypoxia-induced Neuronal and Inducible Nitric Oxide Synthases in the Retinas of Rats with Oxygen-induced Retinopathy
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Kim SJ, Chung IY, Choi WS, Kim YH, Yoo JM
- KMID: 1499685
- Korean J Ophthalmol.
- 2012 Dec;26(6):455-461.
- doi: 10.3341/kjo.2012.26.6.455
PURPOSE: We investigated whether oxygen-induced retinopathy (OIR) results in changes in the protein expression of neuronal and inducible nitric oxide synthases (nNOS and iNOS, respectively) in rat model of OIR.... -
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- Winged Scapula Caused by Rhomboideus and Trapezius Muscles Rupture Associated with Repetitive Minor Trauma: A Case Report
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Lee SG, Kim JH, Lee SY, Choi IS, Moon ES
- KMID: 1778450
- J Korean Med Sci.
- 2006 Jun;21(3):581-584.
- doi: 10.3346/jkms.2006.21.3.581
We experienced a rare case of winged scapula that was caused by the rupture of the rhomboideus major and the lower trapezius muscles without any nerve injury in a 12... -
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