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Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation

Song J, Oh Y, Kim JY, Cho KJ, Lee JE

PURPOSE: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects...
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Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells

Kim BW, Son H

  • KMID: 1115952
  • Exp Mol Med.
  • 2006 Dec;38(6):732-738.
It has been shown that neural cell adhesion molecule (NCAM)-induced neuronal differentiation is extracellular signal-regulated kinase (ERK)-dependent. However, an involvement of the mitogen activated protein kinase (MAPK) kinase (MEK), an...
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Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells

Seo SR, Seo JT

Differentiation of neuronal cells has been shown to accelerate stress-induced cell death, but the underlying mechanisms are not completely understood. Here, we find that early and sustained increase in cytosolic...
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Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo

Park KW, Lee HG, Jin BK, Lee YB

  • KMID: 1091076
  • Exp Mol Med.
  • 2007 Dec;39(6):812-819.
A degree of brain inflammation is required for repair of damaged tissue, but excessive inflammation causes neuronal cell death. Here, we observe that IL-10 is expressed in LPS-injected rat cerebral...
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Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG

  • KMID: 1105280
  • Exp Mol Med.
  • 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,...
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