- Cancer Metastasis and Metastasis Suppressors
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Song IH
- KMID: 1111502
- Korean J Gastroenterol.
- 2004 Jan;43(1):1-7.
Cancer metastasis, a complex and sequential network of cellular events involved in the migration and establishment of malignant cells from original site to distant foci, is an important and significant... -
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- Enhanced expression of cathepsin L in metastatic bone tumors
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Park IC, Lee SY, Jeon DG, Lee JS, Hwang CS, Hwang YG, Lee SH, Hong WS, Hong SI
- KMID: 644942
- J Korean Med Sci.
- 1996 Apr;11(2):144-148.
- doi: 10.3346/jkms.1996.11.2.144
Cathepsin L is a kind of cystein proteases which are known to facilitate the invasion and metastasis of tumor cells by degrading the components of basement membrane and extracellular matrix.... -
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- Clinical Significance of Aberrant Wnt7a Promoter Methylation in Human Non-Small Cell Lung Cancer in Koreans
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Kim TH, Moon JY, Kim SH, Paik SS, Yoon HJ, Shin DH, Park SS, Sohn JW
- KMID: 2129645
- J Korean Med Sci.
- 2015 Feb;30(2):155-161.
- doi: 10.3346/jkms.2015.30.2.155
The Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, and polarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation and cancer, and loss of Wnt7a expression... -
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- miR-98 suppresses melanoma metastasis through a negative feedback loop with its target gene IL-6
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Li F, Li XJ, Qiao L, Shi F, Liu W, Li Y, Dang YP, Gu WJ, Wang XG, Liu W
- KMID: 2155381
- Exp Mol Med.
- 2014 Oct;46(10):e116.
- doi: 10.1038/emm.2014.63
Dysregulated microRNA (miRNA) expression has a critical role in tumor development and metastasis. However, the mechanism by which miRNAs control melanoma metastasis is unknown. Here, we report reduced miR-98 expression... -
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- DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
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Sung HY, Ju W, Ahn JH
- KMID: 2070216
- Yonsei Med J.
- 2014 Nov;55(6):1656-1663.
- doi: 10.3349/ymj.2014.55.6.1656
PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads... -
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- Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma
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Subramani , Lopez-Valdez R, Salcido A, Boopalan T, Arumugam A, Nandy S, Lakshmanaswamy R
- KMID: 2155382
- Exp Mol Med.
- 2014 Oct;46(10):e117.
- doi: 10.1038/emm.2014.61
Pancreatic cancer is the only major cancer with very low survival rates (1%). It is the fourth leading cause of cancer-related death. Hyperactivated growth hormone receptor (GHR) levels have been... -
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