- Immunohistochemical Analysis of Nuclear Factor, p38, and Cyclin D1 Proteins in Premalignant Lesions and Carcinomas of the Colorectal Mucosa
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Lee SD, Lee TJ, Park ES
- KMID: 783112
- Korean J Gastroenterol.
- 2008 Dec;52(6):359-367.
BACKGROUND/AIMS: Nuclear factor-kappa B p65 (NF-kappa B p65), nuclear factor-kappa B1 p50 (NF-kappa B p50) have been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis.... -
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- Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis
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Jue DM, Jeon KI, Jeong JY
- KMID: 646299
- J Korean Med Sci.
- 1999 Jun;14(3):231-238.
- doi: 10.3346/jkms.1999.14.3.231
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint swelling and progressive destruction of cartilage and bone. Current RA treatments are largely empirical in origin and their... -
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- SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice
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Bae UJ, Yang JD, Ka SO, Koo JH, Woo SJ, Lee YR, Yu HC, Cho BH, Zhao HY, Ryu JH, Lee SM, Jeon R, Park BH
- KMID: 2155374
- Exp Mol Med.
- 2014 Aug;46(8):e109.
- doi: 10.1038/emm.2014.48
Hepatic ischemia/reperfusion (I/R) injury leads to oxidative stress and acute inflammatory responses that cause liver damage and have a considerable impact on the postoperative outcome. Much research has been performed... -
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- Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
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Park EJ, Kwon TK
- KMID: 1058704
- Exp Mol Med.
- 2011 Dec;43(12):669-675.
- doi: 10.3858/emm.2011.43.12.077
Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231... -
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