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Strategies for ensuring that regenerative cardiomyocytes function properly and in cooperation with the host myocardium

Hattori F, Fukuda K

In developed countries, in which people have nutrient-rich diets, convenient environments, and access to numerous medications, the disease paradigm has changed. Nowadays, heart failure is one of the major causes...
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5-azacytidine induces cardiac differentiation of P19 embryonic stem cells

Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS

  • KMID: 1103318
  • Exp Mol Med.
  • 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of...
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Use of Long-term Cultured Embryoid Bodies May Enhance Cardiomyocyte Differentiation by BMP2

Kim YY, Ku SY, Jang J, Oh SK, Kim HS, Kim SH, Choi YM, Moon SY

PURPOSE: Human embryonic stem cells (hESCs) can proliferate for a prolonged period and differentiate into cardiomyocytes in vitro. Recent studies used bone morphogenetic protein 2 (BMP2) to generate cardiomyocytes from...
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