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Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus

Kim GJ, Lee ES

We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28(+3) weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly...
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A Case of Pure Red Cell Anemia Complicated by Antiepileptic Drugs

Kim H, Park SG, Kim SR

  • KMID: 2104467
  • J Korean Pediatr Soc.
  • 1999 Feb;42(2):264-267.
A 12-year-old boy developed pure red cell anemia(PRCA) during a combination therapy of antiepileptic drugs(AEDs) for epilepsy. His complex partial seizure was intractable to monotherapy. During 7 months of treatment,...
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Down Syndrome with Transient Myeloproliferative Disorder, Hepatic Fibrosis, and Hemochromatosis

Lee JY, Im HK, Kim HM, Lim BK, Uh Y, Park CI

  • KMID: 2188690
  • J Korean Soc Neonatol.
  • 2003 May;10(1):83-87.
Transient myeloproliferative disorder (TMD), which may mimic acute leukemia, occurs in neonates with Down syndrome along with hepatic fibrosis. TMD is recognized shortly after birth or in the neonatal period...
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Acute Megakaryoblastic Leukemia with CD41a-/CD61-/CD42a+ Blasts in an Infant with Down Syndrome

Ko K, Kwon MJ, Jang MA, Lee ST, Woo HY, Park H, Kim SH

  • KMID: 2312251
  • Lab Med Online.
  • 2014 Apr;4(2):112-115.
Infants with Down syndrome have increased incidences of transient abnormal myelopoiesis (TAM) and acute leukemia, which are usually associated with acute megakaryoblastic leukemia (AMKL). A 5-day-old girl with Down syndrome...
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Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD

Lee YK, Ju JM, Shon WJ, Oh S, Min CK, Kang MS, Shin DM, Choi EY

Graft-versus-host disease (GVHD), a life-threatening complication after bone marrow transplantation (BMT), is induced by activation of alloreactive donor T cells. Our previous study demonstrated that transplantation of myeloid differentiation factor...
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