Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

PUBLICATION DATE

28 results
Display

Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation

Jeong S, Ko J, Kim M, Park KC, Park EY, Kim J, Baik Y, Wie J, Cho AE, Jeon JH, So I

The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency

Mo EY, Lee JY, Kim SY, Kim MJ, Kim ES, Lee S, Han JH, Moon SD

BACKGROUND: We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 (CYP17A1) gene. One allele had a p.His373Leu and the other...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Utility of BRAF VE1 Immunohistochemistry as a Screening Tool for Colorectal Cancer Harboring BRAF V600E Mutation

Kwon JH, Jeong BK, Yoon YS, Yu CS, Kim J

BACKGROUND: BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) for targeted therapy and prognosis prediction. However, sequencing for every CRC case is not cost-effective. An...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
A De Novo RAPGEF2 Variant Identified in a Sporadic Amyotrophic Lateral Sclerosis Patient Impairs Microtubule Stability and Axonal Mitochondria Distribution

Heo K, Lim SM, Nahm M, Kim YE, Oh KW, Park HT, Ki CS, Kim SH, Lee S

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is frequently linked to microtubule abnormalities and mitochondrial trafficking defects. Whole exome sequencing (WES) of patient-parent trios has proven to...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Evaluation of the VE1 Antibody in Thyroid Cytology Using Ex Vivo Papillary Thyroid Carcinoma Specimens

Kim YH, Yim H, Lee YH, Han JH, Lee KB, Lee J, Soh EY, Jeong SY, Kim JH

BACKGROUND: Recently, VE1, a monoclonal antibody against the BRAFV600E mutant protein, has been investigated in terms of its detection of the BRAFV600E mutation. Although VE1 immunostaining and molecular methods used...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Development of cell models for high-throughput screening system of Charcot-Marie-Tooth disease type 1

Choi YR, Jung SC, Shin J, Yoo SY, Lee JS, Joo J, Lee J, Hong YB, Choi BO

PURPOSE: Charcot-Marie-Tooth disease (CMT) is a peripheral neuropathy mainly divided into CMT type 1 (CMT1) and CMT2 according to the phenotype and genotype. Although molecular pathologies for each genetic causative...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W

  • KMID: 2154255
  • Exp Mol Med.
  • 2013 Aug;45(8):e36.
Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes

Yu SM, Kim HA, Kim SJ

2-deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various cellular responses including proliferation, apoptosis and differentiation by regulation of glucose metabolism in cancer cells. However, the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Molecular Approach for Distal Renal Tubular Acidosis Associated AE1 Mutations

Vasuvattakul S

The molecular approaches to distal renal tubular acidosis (dRTA) associated AE1 mutations lead us to understand the genetic and pathophysiological aspects of the acidification defects. An unanticipated high value of...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation

Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS

Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Autophagy and Neurodegenerative Diseases

Paek J, Kim B

  • KMID: 1813203
  • J Korean Neurol Assoc.
  • 2009 Aug;27(3):206-214.
Autophagy is a highly regulated cellular mechanism that results in the bulk degradation of long-lived proteins and organelles and which seems to be implicated in a variety of physiological and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
CD98 activation increases surface expression and clusteringof beta 1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms

Kim SM, Hahn JH

CD98, a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein, regulates beta 1 integrin- mediated cell adhesion. However, the molecular mechanisms underlying CD98-mediated activation of beta 1 integrin are presently unclear....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Selective Cytotoxic Mechanism of Homocysteine to Motor Neuronal Cells Expressing the Mutant Cu,Zn-superoxide Dismutase

Sung JJ, Kim HJ, Kim SM, Min JH, Hong YH, Park KS, Kim M, Lee SH, Ho WK, Lee KW

  • KMID: 1957679
  • J Korean Neurol Assoc.
  • 2006 Feb;24(1):66-75.
BACKGROUND: Mutations in Cu, Zn-superoxide dismutase (SOD1) cause about 20% of familial amyotrophic lateral sclerosis (FALS) cases. The mechanism of late-onset disease manifestation despite the innate mutation has no clear...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
An alternatively spliced form of Met receptor is tumorigenic

Lee JH, Gao CF, Lee CC, Kim MD, Vande Woude GF

  • KMID: 1098091
  • Exp Mol Med.
  • 2006 Oct;38(5):565-573.
The Met tyrosine kinase receptor is a widely expressed molecule, which mediates pleiotropic cellular responses following activation by its ligand, hepatocyte growth factor/scatter factor (HGF/SF). Previously, one of the authors...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cysteine-179 of I kappa B kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines

Byun MS, Choi J, Jue DM

  • KMID: 1098089
  • Exp Mol Med.
  • 2006 Oct;38(5):546-552.
I kappa B kinase beta (IKK beta) subunit of IKK complex is essential for the activation of NF-kappa B in response to various proinflammatory signals. Cys-179 in the activation loop...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Altered Retinoblastoma Protein Expression and Proliferative Activity in Urethane Induced Mouse Lung Tumorigenesis

Chung JH, Jang JJ, Lee MJ, Ham EK

  • KMID: 1804464
  • Cancer Res Treat.
  • 2002 Aug;34(4):258-263.
Lung cancer develops through a multistage process involving the accumulation of diverse genetic alterations. To gain an understanding of the roles played by tumor suppressor gene proteins and proliferating cell...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Production of Soluble VEGF Receptor Mutants for Inhibition of Angiogenesis

Yun SY, Hong YK, Lee Y, Kim K, Kim HK, Joe YA

  • KMID: 2175025
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):595-604.
PURPOSE: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor of many solid tumors, promoting vascularization and formation of metastases. In an attempt to generate effective VEGF inhibitors, the authors constructed...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Expressions of MAGE-3, PCNA, p21, and p53 Proteins in the Hypopharyngeal Squamous Cell Carcinoma Cell Line (PNUH-12) Analysed by Bivariate Flow Cytometry

Chang HK, Kim DJ, Roh HJ, Hur B, Lee KD, Spagnoli

  • KMID: 1725731
  • Korean J Pathol.
  • 2000 Nov;34(11):901-908.
MAGE (melanoma antigen gene) is a tumor specific shared antigen, presented by HLA class I molecules, which is recognized by cytotoxic T lymphocytes. MAGE proteins are expressed in malignant tumor...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Correlation between Serum p53 Antibody and Tissue Expression of Mutant p53 Protein in Primary Breast Carcinoma Patients

Ahn SH, Moon H, Han S

  • KMID: 2324898
  • J Korean Surg Soc.
  • 2000 Oct;59(4):441-446.
PURPOSE: It has been reported that the antibody against p53 is detected in a certain proportion of patients with malignancies. The authors designed this study to investigate the correlation between...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Clinical Significance of Plasma p53 Protein Level in Acute Leukemia

Oh EJ, Kim Y, Han K, Kim BK, Shim SI

  • KMID: 2083379
  • Korean J Hematol.
  • 1999 May;34(2):297-305.
BACKGROUND: Mutation in the p53 gene occurs frequently in a wide spectrum of human malignancies and the mutant protein may prove to be a useful diagnostic or prognostic marker for...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr