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It has been postulated that the intracellular taurine is co-transported
with Na+ down a concentration gradient and prevents the intracellular
accumulation of sodium. It is therefore, expected that an elevated
level of intracellular...
BACKGROUND: In cancer cells, autophagy is generally induced as a pro-survival mechanism in response to treatment-associated genotoxic and metabolic stress. Thus, concurrent autophagy inhibition can be expected to have a...
Frequency-force relationships (FFR) were studied in electrically field
stimulated rat left atria (LA) by reducing the stimulation frequency
from resting 3 Hz to test frequencies (0.1-1 Hz) for 5 minutes. The
twitch amplitudes...
The underlying mechanism commonly applicable for both the positive and
negative force-frequency relationships (FFR) was pursued in left atria
(LA) of rat and rabbit. The species differences in the roles of
Na+/Ca2+ exchanger...
Recent reports revealed that the Na+/-Ca2+ exchangers and feet
structures of sarcoplasmic reticulum (SR) are located in close vicinity
in the specific compartment. Therefore, we investigated the possibility
that the Na+/-Ca2+ exchanger may...
Recently, indirect evidences suggest that Na-Ca exchange mechanism is involved in bone resorption. To study this suggestion, effects of several drugs which increase the intracellular sodium concentration by different mechanisms...