- Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking
-
Lee IW, Yoon J, Lee G, Lee M
- KMID: 2404052
- Genomics Inform.
- 2017 Dec;15(4):147-155.
- doi: 10.5808/GI.2017.15.4.147
Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers,... -
- CITED
-
- Close
- SHARE
-
- Close
- Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach
-
Jagadeb M, Konkimalla VB, Rath SN, Das RP
- KMID: 2391509
- Genomics Inform.
- 2014 Dec;12(4):283-288.
- doi: 10.5808/GI.2014.12.4.283
Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing... -
- CITED
-
- Close
- SHARE
-
- Close
- Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Toxoplasma gondii Apical Membrane Antigen 1 (AMA1)
-
Vetrivel U, Muralikumar S, Mahalakshmi B, Lily Therese K, Madhavan H, Alameen M, Thirumudi
- KMID: 2328166
- Genomics Inform.
- 2016 Jun;14(2):53-61.
- doi: 10.5808/GI.2016.14.2.53
Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by... -
- CITED
-
- Close
- SHARE
-
- Close
- Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking
-
Sahoo M, Jena L, Rath SN, Kumar S
- KMID: 2353661
- Genomics Inform.
- 2016 Sep;14(3):96-103.
- doi: 10.5808/GI.2016.14.3.96
The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for... -
- CITED
-
- Close
- SHARE
-
- Close
- Estrogenic Activity of Sanguiin H-6 through Activation of Estrogen Receptor α Coactivator-binding Site
-
Trinh TA, Park EJ, Lee D, Song JH, Lee HL, Kim KH, Kim Y, Jung K, Kang KS, Yoo JE
- KMID: 2443100
- Nat Prod Sci.
- 2019 Mar;25(1):28-33.
- doi: 10.20307/nps.2019.25.1.28
A popular approach for the study of estrogen receptor α inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we... -
- CITED
-
- Close
- SHARE
-
- Close
- Virtual Screening for Potential Inhibitors of NS3 Protein of Zika Virus
-
Sahoo M, Jena L, Daf S, Kumar S
- KMID: 2353662
- Genomics Inform.
- 2016 Sep;14(3):104-111.
- doi: 10.5808/GI.2016.14.3.104
Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGEâ‚‚
-
Pun IH, Chan D, Chan SH, Chung PY, Zhou YY, Law S, Lam AK, Chui CH, Chan AS, Lam KH, Tang JC
- KMID: 2367520
- Cancer Res Treat.
- 2017 Jan;49(1):219-229.
- doi: 10.4143/crt.2016.190
PURPOSE: 83b1 is a novel quinoline derivative that has been shown to inhibit cancer growth in human esophageal squamous cell carcinoma (ESCC). This study was conducted to comprehensively evaluate the... -
- CITED
-
- Close
- SHARE
-
- Close
